EC |
4.2.3.32 |
Accepted name: |
levopimaradiene synthase |
Reaction: |
(+)-copalyl diphosphate = abieta-8(14),12-diene + diphosphate |
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For diagram of abietadiene, abietate, isopimaradiene, labdadienol and sclareol biosynthesis, click here and for diagram of abietadiene, levopimaradiene and isopimara-7,15-diene biosynthesis, click here |
Glossary: |
levopimaradiene = abieta-8(14),12-diene |
Other name(s): |
PtTPS-LAS; LPS; copalyl-diphosphate diphosphate-lyase [abieta-8(14),12-diene-forming] |
Systematic name: |
(+)-copalyl-diphosphate diphosphate-lyase [abieta-8(14),12-diene-forming] |
Comments: |
In Ginkgo, the enzyme catalyses the initial cyclization step in the biosynthesis of ginkgolides, a structurally unique family of diterpenoids that are highly specific platelet-activating-factor receptor antagonists [1]. Levopimaradiene is widely distributed in higher plants. In some species the enzyme also forms abietadiene, palustradiene, and neoabietadiene [2]. |
Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc |
References: |
1. |
Schepmann, H.G., Pang, J. and Matsuda, S.P. Cloning and characterization of Ginkgo biloba levopimaradiene synthase which catalyzes the first committed step in ginkgolide biosynthesis. Arch. Biochem. Biophys. 392 (2001) 263–269. [DOI] [PMID: 11488601] |
2. |
Ro, D.K. and Bohlmann, J. Diterpene resin acid biosynthesis in loblolly pine (Pinus taeda): functional characterization of abietadiene/levopimaradiene synthase (PtTPS-LAS) cDNA and subcellular targeting of PtTPS-LAS and abietadienol/abietadienal oxidase (PtAO, CYP720B1). Phytochemistry 67 (2006) 1572–1578. [DOI] [PMID: 16497345] |
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[EC 4.2.3.32 created 2008, modified 2012] |
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EC |
4.2.3.44 |
Accepted name: |
isopimara-7,15-diene synthase |
Reaction: |
(+)-copalyl diphosphate = isopimara-7,15-diene + diphosphate |
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For diagram of abietadiene, abietate, isopimaradiene, labdadienol and sclareol biosynthesis, click here and for diagram of abietadiene, levopimaradiene and isopimara-7,15-diene biosynthesis, click here |
Glossary: |
isopimara-7,15-diene = 13α-pimara-7,15-diene |
Other name(s): |
PaTPS-Iso; copalyl diphosphate-lyase (isopimara-7,15-diene-forming) |
Systematic name: |
(+)-copalyl diphosphate-lyase (isopimara-7,15-diene-forming) |
Comments: |
The enzyme only gave isopimara-7,15-diene. |
Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc |
References: |
1. |
Martin, D.M., Faldt, J. and Bohlmann, J. Functional characterization of nine Norway Spruce TPS genes and evolution of gymnosperm terpene synthases of the TPS-d subfamily. Plant Physiol. 135 (2004) 1908–1927. [DOI] [PMID: 15310829] |
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[EC 4.2.3.44 created 2009] |
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