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Your query returned 7 entries. Printable version
EC | 1.3.1.18 | ||||||||||
Accepted name: | kynurenate-7,8-dihydrodiol dehydrogenase | ||||||||||
Reaction: | 7,8-dihydro-7,8-dihydroxykynurenate + NAD+ = 7,8-dihydroxykynurenate + NADH + H+ | ||||||||||
Other name(s): | 7,8-dihydro-7,8-dihydroxykynurenate dehydrogenase; 7,8-dihydroxykynurenic acid 7,8-diol dehydrogenase | ||||||||||
Systematic name: | 7,8-dihydro-7,8-dihydroxykynurenate:NAD+ oxidoreductase | ||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 37255-30-4 | ||||||||||
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EC | 1.3.99.18 | ||||||||||
Accepted name: | quinaldate 4-oxidoreductase | ||||||||||
Reaction: | quinaldate + acceptor + H2O = kynurenate + reduced acceptor | ||||||||||
Other name(s): | quinaldic acid 4-oxidoreductase | ||||||||||
Systematic name: | quinoline-2-carboxylate:acceptor 4-oxidoreductase (hydroxylating) | ||||||||||
Comments: | The enzyme from Pseudomonas sp. AK2 also acts on quinoline-8-carboxylate, whereas that from Serratia marcescens 2CC-1 will oxidize nicotinate; quinaldate is a substrate for both of these enzymes. 2,4,6-Trinitrobenzene sulfonate, 1,4-benzoquinone, 1,2-naphthoquinone, nitroblue tetrazolium, thionine and menadione will serve as an electron acceptor for the former enzyme and ferricyanide for the latter; Meldola blue, iodonitrotetrazolium chloride, phenazine methosulfate, 2,6-dichlorophenolindophenol and cytochrome c will act as electron acceptors for both. | ||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 149885-77-8 | ||||||||||
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EC | 1.13.1.10 | ||||||||||
Transferred entry: | Now EC 1.13.11.10, 7,8-dihydroxykynurenate 8,8a-dioxygenase | ||||||||||
EC | 1.13.11.10 | ||||||||||
Accepted name: | 7,8-dihydroxykynurenate 8,8a-dioxygenase | ||||||||||
Reaction: | 7,8-dihydroxykynurenate + O2 = 5-(3-carboxy-3-oxopropenyl)-4,6-dihydroxypyridine-2-carboxylate | ||||||||||
Other name(s): | 7,8-dihydroxykynurenate oxygenase; 7,8-dihydroxykynurenate 8,8α-dioxygenase; 7,8-dihydroxykynurenate:oxygen 8,8a-oxidoreductase (decyclizing) | ||||||||||
Systematic name: | 7,8-dihydroxykynurenate:oxygen 8,8a-oxidoreductase (ring-opening) | ||||||||||
Comments: | Requires Fe2+. | ||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 9029-58-7 | ||||||||||
References: |
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EC | 1.14.99.2 | ||||||||||
Accepted name: | kynurenine 7,8-hydroxylase | ||||||||||
Reaction: | kynurenate + reduced acceptor + O2 = 7,8-dihydro-7,8-dihydroxykynurenate + acceptor | ||||||||||
Other name(s): | kynurenic acid hydroxylase; kynurenic hydroxylase; kynurenate 7,8-hydroxylase | ||||||||||
Systematic name: | kynurenate,hydrogen-donor:oxygen oxidoreductase (hydroxylating) | ||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 9029-63-4 | ||||||||||
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EC | 2.6.1.7 | ||||||||||
Accepted name: | kynurenine—oxoglutarate transaminase | ||||||||||
Reaction: | L-kynurenine + 2-oxoglutarate = kynurenate + L-glutamate + H2O (overall reaction) (1a) L-kynurenine + 2-oxoglutarate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate (1b) 4-(2-aminophenyl)-2,4-dioxobutanoate = kynurenate + H2O (spontaneous) |
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For diagram of EC 2.6.1, click here and for diagram of tryptophan catabolism, click here | |||||||||||
Glossary: | kynurenine = 2-amino-4-(2-aminophenyl)-4-oxobutanoic acid = 3-anthraniloylalanine kynurenate = 4-hydroxyquinoline-2-carboxylate |
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Other name(s): | kynurenine transaminase (cyclizing); kynurenine 2-oxoglutarate transaminase; kynurenine aminotransferase; L-kynurenine aminotransferase | ||||||||||
Systematic name: | L-kynurenine:2-oxoglutarate aminotransferase | ||||||||||
Comments: | A pyridoxal-phosphate protein. Also acts on 3-hydroxykynurenine. The product 4-(2-aminophenyl)-2,4-dioxobutanoate is converted into kynurenate by a spontaneous reaction. | ||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 9030-38-0 | ||||||||||
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EC | 2.6.1.63 | ||||||||||
Accepted name: | kynurenine—glyoxylate transaminase | ||||||||||
Reaction: | (1) L-kynurenine + glyoxylate = kynurenate + glycine + H2O (overall reaction) (1a) L-kynurenine + glyoxylate = 4-(2-aminophenyl)-2,4-dioxobutanoate + glycine (1b) 4-(2-aminophenyl)-2,4-dioxobutanoate = kynurenate + H2O (spontaneous) (2) 3-hydroxy-L-kynurenine + glyoxylate = xanthurenate + glycine + H2O (overall reaction) (2a) 3-hydroxy-L-kynurenine + glyoxylate = 4-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoate + glycine (2b) 4-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoate = xanthurenate + H2O (spontaneous) |
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For diagram of EC 2.6.1, click here | |||||||||||
Other name(s): | kynurenine-glyoxylate aminotransferase | ||||||||||
Systematic name: | L-kynurenine:glyoxylate aminotransferase (cyclizing) | ||||||||||
Comments: | This enzyme, characterized from animals, belongs to a family of aminotransferases some members of which can use other amino acceptors (cf. EC 2.6.1.7, kynurenine—oxoglutarate transaminase). The products, 4-(2-aminophenyl)-2,4-dioxobutanoate and 4-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoate, are converted to kynurenate and xanthurenate, respectively, by spontaneous reactions. | ||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 74506-33-5 | ||||||||||
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