EC |
4.2.3.186 |
Accepted name: |
ent-13-epi-manoyl oxide synthase |
Reaction: |
ent-8α-hydroxylabd-13-en-15-yl diphosphate = ent-13-epi-manoyl oxide + diphosphate |
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For diagram of (–)-kolavenyl diphosphate derived diterpenoids, click here |
Glossary: |
Ent-13-epi-manoyl oxide = (13R)-ent-8,13-epoxylabd-14-ene |
Other name(s): |
SmKSL2; ent-LDPP synthase |
Systematic name: |
ent-8α-hydroxylabd-13-en-15-yl-diphosphate diphosphate-lyase (cyclizing, ent-13-epi-manoyl-oxide-forming) |
Comments: |
Isolated from the plant Salvia miltiorrhiza (red sage). |
Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc |
References: |
1. |
Cui, G., Duan, L., Jin, B., Qian, J., Xue, Z., Shen, G., Snyder, J.H., Song, J., Chen, S., Huang, L., Peters, R.J. and Qi, X. Functional divergence of diterpene syntheses in the medicinal plant Salvia miltiorrhiza. Plant Physiol. 169 (2015) 1607–1618. [DOI] [PMID: 26077765] |
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[EC 4.2.3.186 created 2017] |
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EC |
4.2.3.190 |
Accepted name: |
manoyl oxide synthase |
Reaction: |
(13E)-8α-hydroxylabd-13-en-15-yl diphosphate = manoyl oxide + diphosphate |
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For diagram of hydroxylabdenyl diphosphate derived diterpenoids, click here |
Glossary: |
(13E)-8α-hydroxylabd-13-en-15-yl diphosphate = 8-hydroxycopalyl diphosphate
manoyl oxide = (13R)-8,13-epoxylabd-14-ene |
Other name(s): |
GrTPS6; CfTPS3; CfTPS4; MvELS |
Systematic name: |
(13E)-8α-hydroxylabd-13-en-15-yl-diphosphate diphosphate-lyase (manoyl-oxide-forming) |
Comments: |
Manoyl oxide is found in many plants. This enzyme has been isolated from the plants, Grindelia hirsutula (gum weed), Plectranthus barbatus (forskohlii) and Marrubium vulgare (white horehound). |
Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc |
References: |
1. |
Zerbe, P., Hamberger, B., Yuen, M.M., Chiang, A., Sandhu, H.K., Madilao, L.L., Nguyen, A., Hamberger, B., Bach, S.S. and Bohlmann, J. Gene discovery of modular diterpene metabolism in nonmodel systems. Plant Physiol. 162 (2013) 1073–1091. [DOI] [PMID: 23613273] |
2. |
Pateraki, I., Andersen-Ranberg, J., Hamberger, B., Heskes, A.M., Martens, H.J., Zerbe, P., Bach, S.S., Moller, B.L., Bohlmann, J. and Hamberger, B. Manoyl oxide (13R), the biosynthetic precursor of forskolin, is synthesized in specialized root cork cells in Coleus forskohlii. Plant Physiol. 164 (2014) 1222–1236. [DOI] [PMID: 24481136] |
3. |
Zerbe, P., Chiang, A., Dullat, H., O'Neil-Johnson, M., Starks, C., Hamberger, B. and Bohlmann, J. Diterpene synthases of the biosynthetic system of medicinally active diterpenoids in Marrubium vulgare. Plant J. 79 (2014) 914–927. [DOI] [PMID: 24990389] |
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[EC 4.2.3.190 created 2017] |
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