The Enzyme Database

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EC 1.2.1.53     
Accepted name: 4-hydroxyphenylacetaldehyde dehydrogenase
Reaction: 4-hydroxyphenylacetaldehyde + NAD+ + H2O = 4-hydroxyphenylacetate + NADH + 2 H+
Other name(s): 4-HPAL dehydrogenase
Systematic name: 4-hydroxyphenylacetaldehyde:NAD+ oxidoreductase
Comments: With EC 4.2.1.87 octopamine dehydratase, brings about the metabolism of octopamine in Pseudomonas.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 109456-56-6
References:
1.  Cuskey, S.M., Peccoraro, V. and Olsen, R.H. Initial catabolism of aromatic biogenic amines by Pseudomonas aeruginosa PAO: pathway description, mapping of mutations, and cloning of essential genes. J. Bacteriol. 169 (1987) 2398–2404. [DOI] [PMID: 3034855]
[EC 1.2.1.53 created 1989]
 
 
EC 4.2.1.87     
Accepted name: octopamine dehydratase
Reaction: 1-(4-hydroxyphenyl)-2-aminoethanol = (4-hydroxyphenyl)acetaldehyde + NH3
Glossary: octopamine = 1-(4-hydroxyphenyl)-2-aminoethanol
Other name(s): octopamine hydrolyase; octopamine hydro-lyase (deaminating)
Systematic name: 1-(4-hydroxyphenyl)-2-aminoethanol hydro-lyase [deaminating; (4-hydroxyphenyl)acetaldehyde-forming]
Comments: The enzyme-catalysed reaction is believed to be dehydration to an enamine, which is spontaneously hydrolysed to an aldehyde and ammonia.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 109456-55-5
References:
1.  Cuskey, S.M., Peccoraro, V. and Olsen, R.H. Initial catabolism of aromatic biogenic amines by Pseudomonas aeruginosa PAO: pathway description, mapping of mutations, and cloning of essential genes. J. Bacteriol. 169 (1987) 2398–2404. [DOI] [PMID: 3034855]
[EC 4.2.1.87 created 1989]
 
 


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