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Your query returned 3 entries. Printable version
EC | 1.14.13.178 | ||||||||
Accepted name: | methylxanthine N1-demethylase | ||||||||
Reaction: | (1) caffeine + O2 + NAD(P)H + H+ = theobromine + NAD(P)+ + H2O + formaldehyde (2) theophylline + O2 + NAD(P)H + H+ = 3-methylxanthine + NAD(P)+ + H2O + formaldehyde (3) paraxanthine + O2 + NAD(P)H + H+ = 7-methylxanthine + NAD(P)+ + H2O + formaldehyde |
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Glossary: | caffeine = 1,3,7-trimethylxanthine theobromine = 3,7-dimethylxanthine theophylline = 1,3-dimethylxanthine paraxanthine = 1,7-dimethylxanthine |
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Other name(s): | ndmA (gene name) | ||||||||
Systematic name: | caffeine:oxygen oxidoreductase (N1-demethylating) | ||||||||
Comments: | A non-heme iron oxygenase. The enzyme from the bacterium Pseudomonas putida shares an NAD(P)H-FMN reductase subunit with EC 1.14.13.179, methylxanthine N3-demethylase, and has a 5-fold higher activity with NADH than with NADPH [2]. Also demethylate 1-methylxantine with lower efficiency. Forms part of the degradation pathway of methylxanthines. | ||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB | ||||||||
References: |
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EC | 2.1.1.159 | ||||||||
Accepted name: | theobromine synthase | ||||||||
Reaction: | S-adenosyl-L-methionine + 7-methylxanthine = S-adenosyl-L-homocysteine + 3,7-dimethylxanthine | ||||||||
For diagram of caffeine biosynthesis, click here | |||||||||
Glossary: | theobromine = 3,7-dimethylxanthine paraxanthine = 1,7-dimethylxanthine |
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Other name(s): | monomethylxanthine methyltransferase; MXMT; CTS1; CTS2; S-adenosyl-L-methionine:7-methylxanthine 3-N-methyltransferase | ||||||||
Systematic name: | S-adenosyl-L-methionine:7-methylxanthine N3-methyltransferase | ||||||||
Comments: | This is the third enzyme in the caffeine-biosynthesis pathway. This enzyme can also catalyse the conversion of paraxanthine into caffeine, although the paraxanthine pathway is considered to be a minor pathway for caffeine biosynthesis [2,3]. | ||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||||||||
References: |
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EC | 2.1.1.160 | ||||||||
Accepted name: | caffeine synthase | ||||||||
Reaction: | (1) S-adenosyl-L-methionine + 3,7-dimethylxanthine = S-adenosyl-L-homocysteine + 1,3,7-trimethylxanthine (2) S-adenosyl-L-methionine + 1,7-dimethylxanthine = S-adenosyl-L-homocysteine + 1,3,7-trimethylxanthine (3) S-adenosyl-L-methionine + 7-methylxanthine = S-adenosyl-L-homocysteine + 3,7-dimethylxanthine |
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For diagram of caffeine biosynthesis, click here | |||||||||
Glossary: | theobromine = 3,7-dimethylxanthine paraxanthine = 1,7-dimethylxanthine caffeine = 1,3,7-trimethylxanthine |
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Other name(s): | dimethylxanthine methyltransferase; 3N-methyltransferase; DXMT; CCS1; S-adenosyl-L-methionine:3,7-dimethylxanthine 1-N-methyltransferase | ||||||||
Systematic name: | S-adenosyl-L-methionine:3,7-dimethylxanthine N1-methyltransferase | ||||||||
Comments: | Paraxanthine is the best substrate for this enzyme but the paraxanthine pathway is considered to be a minor pathway for caffeine biosynthesis [2,3]. | ||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB | ||||||||
References: |
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