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Your query returned 7 entries. 
Printable version
| EC | 2.1.1.144 | ||||||||
| Accepted name: | trans-aconitate 2-methyltransferase | ||||||||
| Reaction: | S-adenosyl-L-methionine + trans-aconitate = S-adenosyl-L-homocysteine + (E)-3-(methoxycarbonyl)pent-2-enedioate | ||||||||
| For diagram of reaction, click here | |||||||||
| Glossary: | trans-aconitate = (E)-prop-1-ene-1,2,3-tricarboxylate | ||||||||
| Systematic name: | S-adenosyl-L-methionine:(E)-prop-1-ene-1,2,3-tricarboxylate 2′-O-methyltransferase | ||||||||
| Comments: | Also catalyses the formation of the methyl monoester of cis-aconitate, isocitrate and citrate, but more slowly. While the enzyme from Escherichia coli forms (E)-3-(methoxycarbonyl)-pent-2-enedioate as the product, that from Saccharomyces cerevisiae forms (E)-2-(methoxycarbonylmethyl)butenedioate and is therefore classified as a separate enzyme (cf. EC 2.1.1.145, trans-aconitate 3-methyltransferase). | ||||||||
| Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 235107-12-7 | ||||||||
| References: |
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| EC | 2.1.1.145 | ||||||||
| Accepted name: | trans-aconitate 3-methyltransferase | ||||||||
| Reaction: | S-adenosyl-L-methionine + trans-aconitate = S-adenosyl-L-homocysteine + (E)-2-(methoxycarbonylmethyl)butenedioate | ||||||||
| For diagram of reaction, click here | |||||||||
| Glossary: | trans-aconitate = (E)-prop-1-ene-1,2,3-tricarboxylate | ||||||||
| Systematic name: | S-adenosyl-L-methionine:(E)-prop-1-ene-1,2,3-tricarboxylate 3′-O-methyltransferase | ||||||||
| Comments: | Also catalyses the formation of the methyl monoester of cis-aconitate, isocitrate and citrate, but more slowly. While the enzyme from Saccharomyces cerevisiae forms (E)-2-(methoxycarbonylmethyl)butenedioate as the product, that from Escherichia coli forms (E)-3-(methoxycarbonyl)-pent-2-enedioate and is therefore classified as a separate enzyme (cf. EC 2.1.1.144, trans-aconitate 2-methyltransferase) | ||||||||
| Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 235107-12-7 | ||||||||
| References: |
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| EC | 4.1.1.6 | ||||||||
| Accepted name: | cis-aconitate decarboxylase | ||||||||
| Reaction: | cis-aconitate = itaconate + CO2 | ||||||||
| Glossary: | itaconate = 2-methylenesuccinate cis-aconitate = (Z)-prop-1-ene-1,2,3-tricarboxylate |
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| Other name(s): | cis-aconitic decarboxylase; cis-aconitate carboxy-lyase; CAD1 (gene name); IRG1 (gene name) | ||||||||
| Systematic name: | cis-aconitate carboxy-lyase (itaconate-forming) | ||||||||
| Comments: | The enzyme has been characterized from the fungus Aspergillus terreus and from human macrophages. cf. EC 4.1.1.113, trans-aconitate decarboxylase. | ||||||||
| Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 9025-01-8 | ||||||||
| References: |
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| EC | 4.1.1.113 | ||||||||
| Accepted name: | trans-aconitate decarboxylase | ||||||||
| Reaction: | trans-aconitate = itaconate + CO2 | ||||||||
| Glossary: | trans-aconitate = (E)-prop-1-ene-1,2,3-tricarboxylate itaconate = 2-methylenesuccinate |
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| Other name(s): | TAD1 (gene name) | ||||||||
| Systematic name: | trans-aconitate carboxy-lyase (itaconate-forming) | ||||||||
| Comments: | The enzyme, characterized from the smut fungus Ustilago maydis, is involved in an alternative pathway for the biosynthesis of itaconate. cf. EC 4.1.1.6, cis-aconitate decarboxylase. | ||||||||
| Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||||||||
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| EC | 4.2.1.3 | ||||||||
| Accepted name: | aconitate hydratase | ||||||||
| Reaction: | citrate = isocitrate (overall reaction) (1a) citrate = cis-aconitate + H2O (1b) cis-aconitate + H2O = isocitrate |
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| For diagram of the citric acid cycle, click here and for diagram of the glyoxylate cycle, click here | |||||||||
| Glossary: | isocitrate = (1R,2S)-1-hydroxypropane-1,2,3-tricarboxylate (previously known as threo-Ds-isocitrate) cis-aconitate = (Z)-prop-1-ene-1,2,3-tricarboxylate |
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| Other name(s): | cis-aconitase; aconitase; AcnB; 2-methylaconitate hydratase; citrate(isocitrate) hydro-lyase | ||||||||
| Systematic name: | citrate(isocitrate) hydro-lyase (cis-aconitate-forming) | ||||||||
| Comments: | Besides interconverting citrate and cis-aconitate, it also interconverts cis-aconitate with isocitrate and, hence, interconverts citrate and isocitrate. The equilibrium mixture is 91% citrate, 6% isocitrate and 3% aconitate. cis-Aconitate is used to designate the isomer (Z)-prop-1-ene-1,2,3-tricarboxylate. An iron-sulfur protein, containing a [4Fe-4S] cluster to which the substrate binds. | ||||||||
| Links to other databases: | BRENDA, EXPASY, GTD, KEGG, MetaCyc, PDB, CAS registry number: 9024-25-3 | ||||||||
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| EC | 4.2.1.117 | ||||||||
| Accepted name: | 2-methylcitrate dehydratase (2-methyl-trans-aconitate forming) | ||||||||
| Reaction: | (2S,3S)-2-methylcitrate = 2-methyl-trans-aconitate + H2O | ||||||||
| Glossary: | (2S,3S)-2-methylcitrate = (2S,3S)-2-hydroxybutane-1,2,3-tricarboxylate 2-methyl-trans-aconitate = (2E)-but-2-ene-1,2,3-tricarboxylate |
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| Systematic name: | (2S,3S)-2-hydroxybutane-1,2,3-tricarboxylate hydro-lyase (2-methyl-trans-aconitate-forming) | ||||||||
| Comments: | Catalyses the dehydration of (2S,3S)-2-methylcitrate, forming the trans isomer of 2-methyl-aconitate (unlike EC 4.2.1.79, which forms only the cis isomer). Part of a propionate degradation pathway. The enzyme from Shewanella oneidensis can also accept citrate and cis-aconitate, but activity with (2S,3S)-2-methylcitrate was approximately 2.5-fold higher. 2-methylisocitrate and isocitrate were not substrates [1]. An iron-sulfur protein. | ||||||||
| Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||||||||
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| EC | 5.3.3.7 | ||||||||
| Accepted name: | aconitate Δ-isomerase | ||||||||
| Reaction: | trans-aconitate = cis-aconitate | ||||||||
| Glossary: | cis-aconitate = (Z)-prop-1-ene-1,2,3-tricarboxylate trans-aconitate = (E)-prop-1-ene-1,2,3-tricarboxylate |
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| Other name(s): | aconitate isomerase | ||||||||
| Systematic name: | aconitate Δ2-Δ3-isomerase | ||||||||
| Comments: | cis-Aconitate is used to designate the isomer (Z)-prop-1-ene-1,2,3-tricarboxylate. This isomerization could take place either in a direct cis-trans interconversion or by an allylic rearrangement; the enzyme has been shown to catalyse the latter change. | ||||||||
| Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 37318-48-2 | ||||||||
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