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Your query returned 6 entries. 
Printable version
| EC | 1.14.13.176 | ||||
| Transferred entry: | tryprostatin B 6-hydroxylase. Now EC 1.14.14.118, tryprostatin B 6-hydroxylase | ||||
| EC | 1.14.14.118 | ||||
| Accepted name: | tryprostatin B 6-hydroxylase | ||||
| Reaction: | tryprostatin B + [reduced NADPH—hemoprotein reductase] + O2 = 6-hydroxytryprostatin B + [oxidized NADPH—hemoprotein reductase] + H2O | ||||
| Glossary: | tryprostatin B = (3S,8aS)-3-{[2-(3-methylbut-2-en-1-yl)-1H-indol-3-yl]methyl}hexahydropyrrolo[1,2-a]pyrazine-1,4-dione 6-hydroxytryprostatin B = (3S,8aS)-3-{[6-hydroxy-2-(3-methylbut-2-en-1-yl)-1H-indol-3-yl]methyl}hexahydropyrrolo[1,2-a]pyrazine-1,4-dione |
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| Other name(s): | ftmC (gene name) | ||||
| Systematic name: | tryprostatin B,[reduced NADPH—hemoprotein reductase]:oxygen oxidoreductase (6-hydroxytryprostatin B-forming) | ||||
| Comments: | A cytochrome P-450 (heme-thiolate) protein. Involved in the biosynthetic pathways of several indole alkaloids such as tryprostatins, fumitremorgins and verruculogen. | ||||
| Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||||
| References: |
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| EC | 1.14.19.71 | ||||
| Accepted name: | fumitremorgin C synthase | ||||
| Reaction: | tryprostatin A + [reduced NADPH—hemoprotein reductase] + O2 = fumitremorgin C + [oxidized NADPH—hemoprotein reductase] + 2 H2O | ||||
| For diagram of fumitremorgin alkaloid biosynthesis (part 1), click here | |||||
| Glossary: | tryprostatin A = (3S,8aS)-3-{[6-methoxy-2-(3-methylbut-2-en-1-yl)-1H-indol-3-yl]methyl}hexahydropyrrolo[1,2-a]pyrazine-1,4-dione fumitremorgin C = (5aS,12S,14aS)-9-methoxy-12-(2-methylprop-1-en-1-yl)-1,2,3,5a,6,11,12,14a-octahydro-5H,14H-pyrrolo[1′′,2′′:4′,5′]pyrazino[1′,2′:1,6]pyrido[3,4-b]indole-5,14-dione |
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| Other name(s): | ftmE (gene name) | ||||
| Systematic name: | tryprostatin A,[reduced NADPH—hemoprotein reductase]:oxygen oxidoreductase | ||||
| Comments: | A cytochrome P-450 (heme-thiolate) protein. The protein from the fungus Aspergillus fumigatus also has activity with tryprostatin B forming demethoxyfumitremorgin C. Involved in the biosynthetic pathways of several indole alkaloids such as fumitremorgins and verruculogen. | ||||
| Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||||
| References: |
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| EC | 1.14.21.10 | ||||
| Transferred entry: | fumitremorgin C synthase. Now EC 1.14.19.71, fumitremorgin C synthase | ||||
| EC | 2.1.1.293 | ||||
| Accepted name: | 6-hydroxytryprostatin B O-methyltransferase | ||||
| Reaction: | S-adenosyl-L-methionine + 6-hydroxytryprostatin B = S-adenosyl-L-homocysteine + tryprostatin A | ||||
| For diagram of fumitremorgin alkaloid biosynthesis (part 1), click here | |||||
| Glossary: | 6-hydroxytryprostatin B = (3S,8aS)-3-{[6-hydroxy-2-(3-methylbut-2-en-1-yl)-1H-indol-3-yl]methyl}hexahydropyrrolo[1,2-a]pyrazine-1,4-dione tryprostatin A = (3S,8aS)-3-{[6-methoxy-2-(3-methylbut-2-en-1-yl)-1H-indol-3-yl]methyl}hexahydropyrrolo[1,2-a]pyrazine-1,4-dione |
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| Other name(s): | ftmD (gene name) | ||||
| Systematic name: | S-adenosyl-L-methionine:6-hydroxytryprostatin B O-methyltransferase | ||||
| Comments: | Involved in the biosynthetic pathways of several indole alkaloids such as tryprostatins, fumitremorgins and verruculogen. | ||||
| Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||||
| References: |
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| EC | 2.5.1.106 | ||||
| Accepted name: | tryprostatin B synthase | ||||
| Reaction: | prenyl diphosphate + brevianamide F = diphosphate + tryprostatin B | ||||
| For diagram of fumitremorgin alkaloid biosynthesis (part 1), click here | |||||
| Glossary: | brevianamide F = (3S,8aS)-3-(1H-indol-3-ylmethyl)hexahydropyrrolo[1,2-a]pyrazine-1,4-dione tryprostatin B = (3S,8aS)-3-{[2-(3-methylbut-2-en-1-yl)-1H-indol-3-yl]methyl}hexahydropyrrolo[1,2-a]pyrazine-1,4-dione |
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| Other name(s): | ftmPT1 (gene name); brevianamide F prenyltransferase (ambiguous); dimethylallyl-diphosphate:brevianamide-F dimethylallyl-C-2-transferase | ||||
| Systematic name: | prenyl-diphosphate:brevianamide-F prenyl-C-2-transferase | ||||
| Comments: | The enzyme from the fungus Aspergillus fumigatus can also prenylate other tryptophan-containing cyclic dipeptides. Prenylation occurs mainly at C-2 [1], but also at C-3 [2]. Involved in the biosynthetic pathways of several indole alkaloids such as tryprostatins, cyclotryprostatins, spirotryprostatins, fumitremorgins and verruculogen. | ||||
| Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB | ||||
| References: |
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