3-Hydroxypropanoate/4-hydroxybutanoate Cycle and
Dicarboxylate/4-hydroxybutanoate Cycle in Archaea

The 3-hydroxypropanoate/4-hydroxybutanoate cycle has been detected in species from the Archaea order Sulfolobales and the dicarboxylate/4-hydroxybutanoate cycle in species from the Archaea orders Desulfurococcales and Thermoproteales.

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© IUBMB 2014

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EC malate dehydrogenase
EC 4-hydroxybutyrate dehydrogenase
EC 3-hydroxybutyryl-CoA dehydrogenase
EC 3-hydroxypropionate dehydrogenase (NADP+)
EC malonyl CoA reductase (malonate semialdehyde-forming)
EC succinate-semialdehyde dehydrogenase (acetylating)
EC pyruvate synthase
EC acrylyl-CoA reductase (NADPH)
EC fumarate reductase (CoM/CoB)
EC acetyl-CoA C-acetyltransferase
EC pyruvate, water dikinase
EC phosphoenolpyruvate carboxylase
EC fumarate hydratase
EC 3-hydroxypropionyl-CoA dehydratase
EC 4-hydroxybutanoyl-CoA dehydratase
EC methylmalonyl-CoA epimerase
EC methylmalonyl-CoA mutase
EC succinate—CoA ligase (ADP-forming)
EC 3-hydroxypropionyl-CoA synthase
EC 4-hydroxybutyrate—CoA ligase (AMP forming)
EC 4-hydroxybutyrate—CoA ligase (ADP forming)
EC acetyl-CoA carboxylase
EC propionyl-CoA carboxylase