The Enzyme Database

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EC 1.1.1.235     
Accepted name: 8-oxocoformycin reductase
Reaction: coformycin + NADP+ = 8-oxocoformycin + NADPH + H+
Other name(s): 8-ketodeoxycoformycin reductase
Systematic name: coformycin:NADP+ 8-oxidoreductase
Comments: Si-specific with respect to NADPH. Also reduces 8-oxodeoxy-coformycin to the nucleoside antibiotic deoxycoformycin.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 114995-16-3
References:
1.  Hanvey, J.C., Hawkins, E.S., Baker, D.C. and Suhadolnick, R.J. 8-Ketodeoxycoformycin and 8-ketocoformycin as intermediates in the biosynthesis of 2′-deoxycoformycin and coformycin. Biochemistry 27 (1988) 5790–5795. [PMID: 3052586]
[EC 1.1.1.235 created 1992]
 
 


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