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Your query returned 1 entry. Printable version
EC | 1.1.1.356 | ||
Accepted name: | GDP-L-colitose synthase | ||
Reaction: | GDP-β-L-colitose + NAD(P)+ = GDP-4-dehydro-3,6-dideoxy-α-D-mannose + NAD(P)H + H+ | ||
For diagram of GDP-colitose biosynthesis, click here | |||
Glossary: | L-colitose = 3,6-dideoxy-L-xylo-hexopyranose GDP-4-dehydro-3,6-dideoxy-α-D-mannose = GDP-3,6-dideoxy-α-D-threo-hexopyranos-4-ulose |
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Other name(s): | ColC | ||
Systematic name: | GDP-β-L-colitose:NAD(P)+ 4-oxidoreductase (5-epimerizing) | ||
Comments: | The enzyme is involved in biosynthesis of L-colitose, a 3,6-dideoxyhexose found in the O-antigen of Gram-negative lipopolysaccharides, where it catalyses the reaction in the reverse direction. The enzyme also performs the NAD(P)H-dependent epimerisation at C-5 of the sugar. The enzyme from Yersinia pseudotuberculosis is Si-specific with respect to NAD(P)H [1]. | ||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||
References: |
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