The enzyme catalyses a step of the pentose phosphate pathway. The enzyme from the archaeon Haloferax volcanii is specific for NAD+. cf. EC 22.214.171.1243, glucose-6-phosphate dehydrogenase [NAD(P)+] and EC 126.96.36.199, glucose-6-phosphate dehydrogenase (NADP+).
Pickl, A. and Schonheit, P. The oxidative pentose phosphate pathway in the haloarchaeon Haloferax volcanii involves a novel type of glucose-6-phosphate dehydrogenase--The archaeal Zwischenferment. FEBS Lett.589 (2015) 1105–1111. [DOI] [PMID: 25836736]