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Accepted name: 3α-hydroxysteroid 3-dehydrogenase (
Reaction: a 3α-hydroxysteroid + NAD(P)
= a 3-oxosteroid + NAD(P)H + H + +
Other name(s): hydroxyprostaglandin dehydrogenase; 3α-hydroxysteroid oxidoreductase; sterognost 3α; 3α-hydroxysteroid dehydrogenase (B-specific); 3α-hydroxysteroid 3-dehydrogenase (B-specific); 3α-hydroxysteroid:NAD(P)
3-oxidoreductase (B-specific) +
Systematic name: 3α-hydroxysteroid:NAD(P)
3-oxidoreductase ( + Si-specific)
Comments: The enzyme acts on androsterone and other 3α-hydroxysteroids and on 9-, 11- and 15-hydroxyprostaglandin.
Si-specific with respect to NAD or NADP + . + cf. EC 22.214.171.124, 3α-hydroxysteroid 3-dehydrogenase ( Re-specific).
Links to other databases:
BRENDA, EXPASY, GTD, KEGG, MetaCyc, PDB, CAS registry number: 9028-56-2
Jarabak, J. and Talalay, P. Stereospecificity of hydrogen transfer by pyridine nucleotide-linked hydroxysteroid hydrogenase.
J. Biol. Chem. 235 (1960) 2147–2151. [PMID: 14406805]
Kochakian, C.D., Carroll, B.R. and Uhri, B. Comparisons of the oxidation of C
-hydroxysteroids by guinea pig liver homogenates. 19 J. Biol. Chem. 224 (1957) 811–818. [PMID: 13405910]
Marcus, P.I. and Talalay, P. Induction and purification of α- and β-hydroxysteroid dehydrogenases.
J. Biol. Chem. 218 (1956) 661–674. [PMID: 13295221]
Penning, T.M. and Sharp, R.B. Prostaglandin dehydrogenase activity of purified rat liver 3α-hydroxysteroid dehydrogenase.
Biochem. Biophys. Res. Commun. 148 (1987) 646–652. [ DOI] [PMID: 3479982]
[EC 126.96.36.199 created 1961, modified 1986, modified 1990, modified 2012, modified 2013]
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