This enzyme participates in the degradation of glutamate and 4-aminobutyrate. It is similar to EC 220.127.116.11 [succinate-semialdehyde dehydrogenase (NADP+)], and EC 18.104.22.168 [succinate-semialdehyde dehydrogenase (NAD(P)+)], but is specific for NAD+.
Albers, R.W. and Koval, G.J. Succinic semialdehyde dehydrogenase : purification and properties of the enzyme from monkey brain. Biochim. Biophys. Acta52 (1961) 29–35. [DOI] [PMID: 13860092]
Ryzlak, M.T. and Pietruszko, R. Human brain "high Km" aldehyde dehydrogenase: purification, characterization, and identification as NAD+ -dependent succinic semialdehyde dehydrogenase. Arch. Biochem. Biophys.266 (1988) 386–396. [DOI] [PMID: 3190233]
Busch, K.B. and Fromm, H. Plant succinic semialdehyde dehydrogenase. Cloning, purification, localization in mitochondria, and regulation by adenine nucleotides. Plant Physiol.121 (1999) 589–597. [PMID: 10517851]