| EC |
1.2.1.25 |
| Accepted name: |
2-oxoisovalerate dehydrogenase (acylating) |
| Reaction: |
3-methyl-2-oxobutanoate + CoA + NAD+ = 2-methylpropanoyl-CoA + CO2 + NADH |
| Other name(s): |
2-oxoisovalerate dehydrogenase; α-ketoisovalerate dehydrogenase |
| Systematic name: |
3-methyl-2-oxobutanoate:NAD+ 2-oxidoreductase (CoA-methyl-propanoylating) |
| Comments: |
Also acts on (S)-3-methyl-2-oxopentanoate and 4-methyl-2-oxopentanoate. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 37211-61-3 |
| References: |
| 1. |
Namba, Y., Yoshizawa, K., Ejima, A., Hayashi, T. and Kaneda, T. Coenzyme A- and nicotinamide adenine dinucleotide-dependent branched chain α-keto acid dehydrogenase. I. Purification and properties of the enzyme from Bacillus subtilis. J. Biol. Chem. 244 (1969) 4437–4447. [PMID: 4308861] |
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| [EC 1.2.1.25 created 1972] |
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