EC |
2.5.1.94 |
Accepted name: |
adenosyl-chloride synthase |
Reaction: |
S-adenosyl-L-methionine + chloride = 5-deoxy-5-chloroadenosine + L-methionine |
Glossary: |
5-deoxy-5-chloroadenosine = 5′-chloro-5′-deoxyadenosine |
Other name(s): |
chlorinase; 5′-chloro-5′-deoxyadenosine synthase |
Systematic name: |
S-adenosyl-L-methionine:chloride adenosyltransferase |
Comments: |
This enzyme, isolated from the marine bacterium Salinispora tropica, catalyses an early step in the pathway leading to biosynthesis of the proteosome inhibitor salinosporamide A. The enzyme is very similar to EC 2.5.1.63, adenosyl-fluoride synthase, but does not accept fluoride. |
Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB |
References: |
1. |
Eustaquio, A.S., Pojer, F., Noel, J.P. and Moore, B.S. Discovery and characterization of a marine bacterial SAM-dependent chlorinase. Nat. Chem. Biol. 4 (2008) 69–74. [DOI] [PMID: 18059261] |
|
[EC 2.5.1.94 created 2011] |
|
|
|
|