The Enzyme Database

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Accepted name: kynurenine—oxoglutarate transaminase
Reaction: L-kynurenine + 2-oxoglutarate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate
For diagram of reaction, click here, of tryptophan catabolism, click here and for diagram of mechanism, click here
Other name(s): kynurenine transaminase (cyclizing); kynurenine 2-oxoglutarate transaminase; kynurenine aminotransferase; L-kynurenine aminotransferase
Systematic name: L-kynurenine:2-oxoglutarate aminotransferase
Comments: A pyridoxal-phosphate protein. Also acts on 3-hydroxykynurenine. The product 4-(2-aminophenyl)-2,4-dioxobutanoate is converted into kynurenate by a spontaneous reaction.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 9030-38-0
1.  Jakoby, W.B. and Bonner, D.M. Kynurenine transaminase from Neurospora. J. Biol. Chem. 221 (1956) 689–695. [PMID: 13357462]
2.  Mason, M. Kynurenine transaminase of rat kidney: a study of coenzyme dissociation. J. Biol. Chem. 227 (1957) 61–68. [PMID: 13449053]
[EC created 1961, modified 1983]

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