EC |
2.7.1.40 |
Accepted name: |
pyruvate kinase |
Reaction: |
ATP + pyruvate = ADP + phosphoenolpyruvate |
|
For diagram of the Entner-Doudoroff pathway, click here |
Other name(s): |
phosphoenolpyruvate kinase; phosphoenol transphosphorylase |
Systematic name: |
ATP:pyruvate 2-O-phosphotransferase |
Comments: |
UTP, GTP, CTP, ITP and dATP can also act as donors. Also phosphorylates hydroxylamine and fluoride in the presence of CO2. |
Links to other databases: |
BRENDA, EXPASY, GTD, KEGG, MetaCyc, PDB, CAS registry number: 9001-59-6 |
References: |
1. |
Boyer, P.D. Pyruvate kinase. In: Boyer, P.D., Lardy, H. and Myrbäck, K. (Ed.), The Enzymes, 2nd edn, vol. 6, Academic Press, New York, 1962, pp. 95–113. |
2. |
Kornberg, A. and Pricer, W.E. Enzymatic phosphorylation of adenosine and 2,6-diaminopurine riboside. J. Biol. Chem. 193 (1951) 481–495. [PMID: 14907737] |
3. |
Kubowitz, F. and Ott, P. Isolierung von Gärungsfermenten aus menschlichen Muskeln. Biochem. Z. 317 (1944) 193–203. |
4. |
Strominger, J.L. Enzymatic synthesis of guanosine and cytidine triphosphates: a note on the nucleotide specificity of the pyruvate phosphokinase reaction. Biochim. Biophys. Acta 16 (1955) 616–618. [DOI] [PMID: 14389299] |
5. |
Tietz, A. and Ochoa, S. "Fluorokinase" and pyruvic kinase. Arch. Biochem. Biophys. 78 (1958) 477–493. [DOI] [PMID: 13618030] |
|
[EC 2.7.1.40 created 1961] |
|
|
|
|