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Your query returned 1 entry. Printable version
EC | 3.1.3.86 | ||||||||||
Accepted name: | phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase | ||||||||||
Reaction: | 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + phosphate | ||||||||||
For diagram of 1-phosphatidyl-myo-inositol metabolism, click here | |||||||||||
Glossary: | 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate = PtdIns(3,4)P2 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate = PtdIns(3,4,5)P3 1-phosphatidyl-1D-myo-inositol 1,3,4,5-trisphosphate = PtdIns(1,3,4,5)P4 |
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Other name(s): | SHIP1; SHIP2; SHIP; p150Ship | ||||||||||
Systematic name: | 1-phosphatidyl-1D-myo-inositol-3,4,5-trisphosphate 5-phosphohydrolase | ||||||||||
Comments: | This enzyme hydrolyses 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. The enzyme also shows activity toward (PtdIns(1,3,4,5)P4) [5]. The enzyme is involved in several signal transduction pathways in the immune system leading to an adverse range of effects. | ||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB | ||||||||||
References: |
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