EC |
3.4.24.81 |
Accepted name: |
ADAM10 endopeptidase |
Reaction: |
Endopeptidase of broad specificity |
Other name(s): |
Kuzbanian protein; myelin-associated disintegrin metalloproteinase |
Comments: |
In peptidase family M12. Partially responsible for the "α-secretase" activity in brain that degrades the potentially harmful β-amyloid peptide. Work with ADAM10-deficient mice supports a role in Notch signalling. |
Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, MEROPS, PDB, CAS registry number: 193099-09-1 |
References: |
1. |
Gutwein, P., Mechtersheimer, S., Riedle, S., Stoeck, A., Gast, D., Joumaa, S., Zentgraf, H., Fogel, M. and Altevogt, D.P. ADAM10-mediated cleavage of L1 adhesion molecule at the cell surface and in released membrane vesicles. FASEB J. 17 (2003) 292–294. [DOI] [PMID: 12475894] |
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[EC 3.4.24.81 created 2003] |
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