EC |
4.2.3.135 |
Accepted name: |
Δ6-protoilludene synthase |
Reaction: |
(2E,6E)-farnesyl diphosphate = Δ6-protoilludene + diphosphate |
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For diagram of bicyclic and tricyclic sesquiterpenoids derived from humuladienyl cation, click here |
Glossary: |
Δ6-protoilludene = (4aS,7aS,7bR)-3,6,6,7b-tetramethyl-2,4,4a,5,6,7,7a,7b-octahydro-1H-cyclobuta[1,2-e]indene |
Other name(s): |
6-protoilludene synthase |
Systematic name: |
(2E,6E)-farnesyl-diphosphate diphosphate-lyase (cyclizing, Δ6-protoilludene-forming) |
Comments: |
Isolated from the fungus Armillaria gallica. Δ6-Protoilludene is the first step in the biosynthesis of the melleolides. |
Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB |
References: |
1. |
Engels, B., Heinig, U., Grothe, T., Stadler, M. and Jennewein, S. Cloning and characterization of an Armillaria gallica cDNA encoding protoilludene synthase, which catalyzes the first committed step in the synthesis of antimicrobial melleolides. J. Biol. Chem. 286 (2011) 6871–6878. [DOI] [PMID: 21148562] |
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[EC 4.2.3.135 created 2012] |
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