The Enzyme Database

Your query returned 3 entries.    printer_iconPrintable version



EC 3.7.1.15      
Transferred entry: (+)-caryolan-1-ol synthase. Now EC 4.2.1.138, (+)-caryolan-1-ol synthase
[EC 3.7.1.15 created 2011, deleted 2013]
 
 
EC 4.2.1.138     
Accepted name: (+)-caryolan-1-ol synthase
Reaction: (+)-β-caryophyllene + H2O = (+)-caryolan-1-ol
For diagram of humulene-based sequiterpenoid biosynthesis, click here
Glossary: (+)-caryolan-1-ol = (1S,2R,5S,8R)-4,4,8-trimethyltricyclo[6.3.1.02,5]dodecan-1-ol
Other name(s): GcoA
Systematic name: (+)-β-caryophyllene hydrolase [cyclizing, (+)-caryolan-1-ol-forming]
Comments: A multifunctional enzyme which also forms (+)-β-caryophyllene from farnesyl diphosphate [EC 4.2.3.89, (+)-β-caryophyllene synthase].
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
References:
1.  Nakano, C., Horinouchi, S. and Ohnishi, Y. Characterization of a novel sesquiterpene cyclase involved in (+)-caryolan-1-ol biosynthesis in Streptomyces griseus. J. Biol. Chem. 286 (2011) 27980–27987. [DOI] [PMID: 21693706]
[EC 4.2.1.138 created 2011 as EC 3.7.1.15, transferred 2013 to EC 4.2.1.138]
 
 
EC 4.2.3.89     
Accepted name: (+)-β-caryophyllene synthase
Reaction: (2E,6E)-farnesyl diphosphate = (+)-β-caryophyllene + diphosphate
For diagram of bicyclic and tricyclic sesquiterpenoids derived from humuladienyl cation, click here
Other name(s): GcoA
Systematic name: (2Z,6E)-farnesyl-diphosphate diphosphate-lyase [cyclizing, (+)-β-caryophyllene-forming]
Comments: A multifunctional enzyme which also converts the (+)-β-caryophyllene to (+)-caryolan-1-ol (see EC 4.2.1.138, (+)-caryolan-1-ol synthase). cf. EC 4.2.3.57 (–)-β-caryophyllene synthase.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
References:
1.  Nakano, C., Horinouchi, S. and Ohnishi, Y. Characterization of a novel sesquiterpene cyclase involved in (+)-caryolan-1-ol biosynthesis in Streptomyces griseus. J. Biol. Chem. 286 (2011) 27980–27987. [DOI] [PMID: 21693706]
[EC 4.2.3.89 created 2011]
 
 


Data © 2001–2020 IUBMB
Web site © 2005–2020 Andrew McDonald