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Your query returned 6 entries. Printable version
EC | 1.3.8.16 | ||||||||||||||
Accepted name: | 2-amino-4-deoxychorismate dehydrogenase | ||||||||||||||
Reaction: | (2S)-2-amino-4-deoxychorismate + FMN = 3-(1-carboxyvinyloxy)anthranilate + FMNH2 | ||||||||||||||
For diagram of enediyne antitumour antibiotic biosynthesis, click here | |||||||||||||||
Glossary: | (2S)-2-amino-4-deoxychorismate = (2S,3S)-3-(1-carboxyvinyloxy)-2,3-dihydroanthranilate 3-enolpyruvoylanthranilate = 3-(1-carboxyvinyloxy)anthranilate |
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Other name(s): | ADIC dehydrogenase; 2-amino-2-deoxyisochorismate dehydrogenase; SgcG | ||||||||||||||
Systematic name: | (2S)-2-amino-4-deoxychorismate:FMN oxidoreductase | ||||||||||||||
Comments: | The sequential action of EC 2.6.1.86, 2-amino-4-deoxychorismate synthase and this enzyme leads to the formation of the benzoxazolinate moiety of the enediyne antitumour antibiotic C-1027 [1,2]. | ||||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||||||||||||||
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EC | 1.3.99.24 | ||||||||||||||
Transferred entry: | 2-amino-4-deoxychorismate dehydrogenase. Now EC 1.3.8.16, 2-amino-4-deoxychorismate dehydrogenase | ||||||||||||||
EC | 2.6.1.86 | ||||||||||||||
Accepted name: | 2-amino-4-deoxychorismate synthase | ||||||||||||||
Reaction: | (2S)-2-amino-4-deoxychorismate + L-glutamate = chorismate + L-glutamine | ||||||||||||||
For diagram of enediyne antitumour antibiotic biosynthesis, click here | |||||||||||||||
Glossary: | (2S)-2-amino-4-deoxychorismate = (2S,3S)-3-(1-carboxyvinyloxy)-2,3-dihydroanthranilate | ||||||||||||||
Other name(s): | ADIC synthase; 2-amino-2-deoxyisochorismate synthase; SgcD | ||||||||||||||
Systematic name: | (2S)-2-amino-4-deoxychorismate:2-oxoglutarate aminotransferase | ||||||||||||||
Comments: | Requires Mg2+. The reaction occurs in the reverse direction to that shown above. In contrast to most anthranilate-synthase I (ASI) homologues, this enzyme is not inhibited by tryptophan. In Streptomyces globisporus, the sequential action of this enzyme and EC 1.3.99.24, 2-amino-4-deoxychorismate dehydrogenase, leads to the formation of the benzoxazolinate moiety of the enediyne antitumour antibiotic C-1027 [1,2]. In certain Pseudomonads the enzyme participates in the biosynthesis of phenazine, a precursor for several compounds with antibiotic activity [3,4]. | ||||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||||||||||||||
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EC | 2.6.1.123 | ||||||||||||||
Accepted name: | 4-amino-4-deoxychorismate synthase (2-amino-4-deoxychorismate-forming) | ||||||||||||||
Reaction: | chorismate + 2 L-glutamine + H2O = 4-amino-4-deoxychorismate + 2 L-glutamate + NH3 (overall reaction) (1a) 2 L-glutamine + 2 H2O = 2 L-glutamate + 2 NH3 (1b) chorismate + NH3 = (2S)-2-amino-4-deoxychorismate + H2O (1c) (2S)-2-amino-4-deoxychorismate + NH3 = 4-amino-4-deoxychorismate + NH3 |
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Other name(s): | ADCS (ambiguous); ADC synthase (ambiguous); pabAB (gene names) | ||||||||||||||
Systematic name: | chorismate:L-glutamine aminotransferase (2-amino-4-deoxychorismate-forming) | ||||||||||||||
Comments: | The enzyme, characterized from the bacterium Bacillus subtilis, is a heterodimer. The PabA subunit acts successively on two molecules of L-glutamine, hydrolysing each to L-glutamate and ammonia (cf. EC 3.5.1.2, glutaminase). The ammonia molecules are channeled to the active site of PabB, which catalyses the formation of 4-amino-4-deoxychorismate from chorismate in two steps via the intermediate 2-amino-4-deoxychorismate. cf. EC 2.6.1.85, aminodeoxychorismate synthase. | ||||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB | ||||||||||||||
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EC | 3.3.2.15 | ||||||||||||||
Accepted name: | trans-2,3-dihydro-3-hydroxyanthranilic acid synthase | ||||||||||||||
Reaction: | (2S)-2-amino-4-deoxychorismate + H2O = (5S,6S)-6-amino-5-hydroxycyclohexa-1,3-diene-1-carboxylate + pyruvate | ||||||||||||||
For diagram of enediyne antitumour antibiotic biosynthesis and pyocyanin biosynthesis, click here | |||||||||||||||
Glossary: | (5S,6S)-6-amino-5-hydroxycyclohexa-1,3-diene-1-carboxylate = trans-2,3-dihydro-3-hydroxyanthranilate | ||||||||||||||
Other name(s): | isochorismatase (ambiguous); phzD (gene name) | ||||||||||||||
Systematic name: | (2S)-2-amino-4-deoxychorismate pyruvate-hydrolase | ||||||||||||||
Comments: | Isolated from the bacterium Pseudomonas aeruginosa. Involved in phenazine biosynthesis. | ||||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB | ||||||||||||||
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EC | 4.1.3.27 | ||||||||||||||
Accepted name: | anthranilate synthase | ||||||||||||||
Reaction: | chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate (overall reaction) (1a) L-glutamine + H2O = L-glutamate + NH3 (1b) chorismate + NH3 = (2S)-2-amino-4-deoxychorismate + H2O (1c) (2S)-2-amino-4-deoxychorismate = anthranilate + pyruvate |
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For diagram of tryptophan biosynthesis, click here | |||||||||||||||
Other name(s): | anthranilate synthetase; chorismate lyase; chorismate pyruvate-lyase (amino-accepting); TrpDE | ||||||||||||||
Systematic name: | chorismate pyruvate-lyase (amino-accepting; anthranilate-forming) | ||||||||||||||
Comments: | The enzyme, found in plants, fungi and bacteria is composed of two parts, a glutaminase subunit and a lyase subunit. The glutaminase produces ammonia that is channeled to the lyase subunit. In the absence of the glutaminase, the lyase can convert ammonia and chorismate into anthranilate. In some organisms, this enzyme is part of a multifunctional protein, together with one or more other components of the system for the biosynthesis of tryptophan [EC 2.4.2.18 (anthranilate phosphoribosyltransferase), EC 4.1.1.48 (indole-3-glycerol-phosphate synthase), EC 4.2.1.20 (tryptophan synthase) and EC 5.3.1.24 (phosphoribosylanthranilate isomerase)]. | ||||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 9031-59-8 | ||||||||||||||
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