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Your query returned 18 entries. Printable version
EC | 1.23.1.3 | Relevance: 100% | ||||||||||||
Accepted name: | (–)-pinoresinol reductase | |||||||||||||
Reaction: | (–)-lariciresinol + NADP+ = (–)-pinoresinol + NADPH + H+ | |||||||||||||
For diagram of (–)-lariciresinol biosynthesis, click here | ||||||||||||||
Glossary: | (–)-lariciresinol = 4-[(2R,3S,4S)-4-[(4-hydroxy-3-methoxyphenyl)methyl]-3-(hydroxymethyl)oxolan-2-yl]-2-methoxyphenol (–)-pinoresinol = (1R,3aS,4R,6aS)-4,4′-(tetrahydro-1H,3H-furo[3,4-c]furan-1,4-diyl)bis(2-methoxyphenol) |
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Other name(s): | pinoresinol/lariciresinol reductase; pinoresinol-lariciresinol reductases; (–)-pinoresinol-(–)-lariciresinol reductase; PLR | |||||||||||||
Systematic name: | (–)-lariciresinol:NADP+ oxidoreductase | |||||||||||||
Comments: | The reaction is catalysed in vivo in the opposite direction to that shown. A multifunctional enzyme that usually further reduces the product to (+)-secoisolariciresinol [EC 1.23.1.4, (–)-lariciresinol reductase]. Isolated from the plants Thuja plicata (western red cedar) [1], Linum perenne (perennial flax) [2] and Arabidopsis thaliana (thale cress) [3]. | |||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB | |||||||||||||
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EC | 1.23.1.1 | Relevance: 79% | ||||||||||||
Accepted name: | (+)-pinoresinol reductase | |||||||||||||
Reaction: | (+)-lariciresinol + NADP+ = (+)-pinoresinol + NADPH + H+ | |||||||||||||
For diagram of matairesinol biosynthesis, click here | ||||||||||||||
Glossary: | (+)-lariciresinol = 4-[(2S,3R,4R)-4-[(4-hydroxy-3-methoxyphenyl)methyl]-3-(hydroxymethyl)oxolan-2-yl]-2-methoxyphenol (+)-pinoresinol = (1S,3aR,4S,6aR)-4,4-(tetrahydro-1H,3H-furo[3,4-c]furan-1,4-diyl)bis(2-methoxyphenol) |
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Other name(s): | pinoresinol/lariciresinol reductase; pinoresinol-lariciresinol reductases; (+)-pinoresinol/(+)-lariciresinol; (+)-pinoresinol-(+)-lariciresinol reductase; PLR | |||||||||||||
Systematic name: | (+)-lariciresinol:NADP+ oxidoreductase | |||||||||||||
Comments: | The reaction is catalysed in vivo in the opposite direction to that shown. A multifunctional enzyme that further reduces the product to the lignan (–)-secoisolariciresinol [EC 1.23.1.2, (+)-lariciresinol reductase]. Isolated from the plants Forsythia intermedia [1,2], Thuja plicata (western red cedar) [3], Linum perenne (perennial flax) [5] and Linum corymbulosum [6]. The 4-pro-R hydrogen of NADH is transferred to the 7-pro-R position of lariciresinol [1]. | |||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB | |||||||||||||
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EC | 1.23.1.4 | Relevance: 75.5% | ||||||||||||
Accepted name: | (–)-lariciresinol reductase | |||||||||||||
Reaction: | (+)-secoisolariciresinol + NADP+ = (–)-lariciresinol + NADPH + H+ | |||||||||||||
For diagram of (#150)-lariciresinol biosynthesis, click here | ||||||||||||||
Glossary: | (–)-lariciresinol = 4-[(2R,3S,4S)-4-[(4-hydroxy-3-methoxyphenyl)methyl]-3-(hydroxymethyl)oxolan-2-yl]-2-methoxyphenol (+)-secoisolariciresinol = (2S,3S)-2,3-bis[(4-hydroxy-3-methoxyphenyl)methyl]butane-1,4-diol |
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Other name(s): | pinoresinol/lariciresinol reductase; pinoresinol-lariciresinol reductases; (–)-pinoresinol-(–)-lariciresinol reductase; PLR | |||||||||||||
Systematic name: | (+)-secoisolariciresinol:NADP+ oxidoreductase | |||||||||||||
Comments: | The reaction is catalysed in vivo in the opposite direction to that shown. A multifunctional enzyme that also reduces (–)-pinoresinol [EC 1.23.1.3, (–)-pinoresinol reductase]. Isolated from the plants Thuja plicata (western red cedar) [1] and Linum corymbulosum [2]. | |||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB | |||||||||||||
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EC | 1.23.1.2 | Relevance: 72.7% | ||||||||||||
Accepted name: | (+)-lariciresinol reductase | |||||||||||||
Reaction: | (–)-secoisolariciresinol + NADP+ = (+)-lariciresinol + NADPH + H+ | |||||||||||||
For diagram of matairesinol biosynthesis, click here | ||||||||||||||
Glossary: | (+)-lariciresinol = 4-[(2S,3R,4R)-4-[(4-hydroxy-3-methoxyphenyl)methyl]-3-(hydroxymethyl)oxolan-2-yl]-2-methoxyphenol (–)-secoisolariciresinol = (2R,3R)-2,3-bis[(4-hydroxy-3-methoxyphenyl)methyl]butane-1,4-diol |
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Other name(s): | pinoresinol/lariciresinol reductase; pinoresinol-lariciresinol reductases; (+)-pinoresinol/(+)-lariciresinol; (+)-pinoresinol-(+)-lariciresinol reductase; PLR | |||||||||||||
Systematic name: | (–)-secoisolariciresinol:NADP+ oxidoreductase | |||||||||||||
Comments: | The reaction is catalysed in vivo in the opposite direction to that shown. A multifunctional enzyme that also reduces (+)-pinoresinol [EC 1.23.1.1, (+)-pinoresinol reductase]. Isolated from the plants Forsythia intermedia [1,2], Thuja plicata (western red cedar) [3], Linum perenne (perennial flax) [5] and Linum corymbulosum [6]. | |||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | |||||||||||||
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EC | 5.3.3.11 | Relevance: 25.9% | ||||||||||||
Accepted name: | isopiperitenone Δ-isomerase | |||||||||||||
Reaction: | isopiperitenone = piperitenone | |||||||||||||
For diagram of (–)-carvone, perillyl aldehyde and pulegone biosynthesis, click here | ||||||||||||||
Systematic name: | isopiperitenone Δ8-Δ4-isomerase | |||||||||||||
Comments: | Involved in the biosynthesis of menthol and related monoterpenes in peppermint (Mentha piperita) leaves. | |||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 96595-07-2 | |||||||||||||
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EC | 1.1.1.243 | Relevance: 24.3% | ||||||||||||
Accepted name: | carveol dehydrogenase | |||||||||||||
Reaction: | (–)-trans-carveol + NADP+ = (–)-carvone + NADPH + H+ | |||||||||||||
For diagram of (–)-carvone, perillyl aldehyde and pulegone biosynthesis, click here | ||||||||||||||
Other name(s): | (–)-trans-carveol dehydrogenase | |||||||||||||
Systematic name: | (–)-trans-carveol:NADP+ oxidoreductase | |||||||||||||
Links to other databases: | BRENDA, EAWAG-BBD, EXPASY, KEGG, MetaCyc, CAS registry number: 122653-66-1 | |||||||||||||
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EC | 5.5.1.28 | Relevance: 23.2% | ||||||||||||
Accepted name: | (–)-kolavenyl diphosphate synthase | |||||||||||||
Reaction: | geranylgeranyl diphosphate = (–)-kolavenyl diphosphate | |||||||||||||
For diagram of (–)-kolavenyl diphosphate derived diterpenoids, click here | ||||||||||||||
Glossary: | (–)-kolavenyl diphosphate = (2E)-5-[(1R,2S,4aS,8aS)-1,2,4a,5-tetramethyl-1,2,3,4,4a,7,8,8a-octahydronaphthalen-1-yl]-3-methylpent-2-en-1-yl diposphate | |||||||||||||
Other name(s): | SdKPS; TwTPS14; TwTPS10/KPS; SdCPS2; clerodienyl diphosphate synthase; CLPP | |||||||||||||
Systematic name: | (–)-kolavenyl diphosphate lyase (ring-opening) | |||||||||||||
Comments: | Isolated from the hallucinogenic plant Salvia divinorum (seer’s sage) and the medicinal plant Tripterygium wilfordii (thunder god vine). | |||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | |||||||||||||
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EC | 4.2.3.186 | Relevance: 23.2% | ||||||||||||
Accepted name: | ent-13-epi-manoyl oxide synthase | |||||||||||||
Reaction: | ent-8α-hydroxylabd-13-en-15-yl diphosphate = ent-13-epi-manoyl oxide + diphosphate | |||||||||||||
For diagram of (–)-kolavenyl diphosphate derived diterpenoids, click here | ||||||||||||||
Glossary: | Ent-13-epi-manoyl oxide = (13R)-ent-8,13-epoxylabd-14-ene | |||||||||||||
Other name(s): | SmKSL2; ent-LDPP synthase | |||||||||||||
Systematic name: | ent-8α-hydroxylabd-13-en-15-yl-diphosphate diphosphate-lyase (cyclizing, ent-13-epi-manoyl-oxide-forming) | |||||||||||||
Comments: | Isolated from the plant Salvia miltiorrhiza (red sage). | |||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | |||||||||||||
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EC | 4.2.3.95 | Relevance: 23.1% | ||||||||||||
Accepted name: | (-)-α-cuprenene synthase | |||||||||||||
Reaction: | (2E,6E)-farnesyl diphosphate = (-)-α-cuprenene + diphosphate | |||||||||||||
For diagram of biosynthesis of bicyclic sesquiterpenoids derived from bisabolyl cation, click here and for diagram of trichodiene and (–)-α-cuprenene biosynthesis, click here | ||||||||||||||
Other name(s): | Cop6 | |||||||||||||
Systematic name: | (-)-α-cuprenene hydrolase [cyclizing, (-)-α-cuprenene-forming] | |||||||||||||
Comments: | The enzyme from the fungus Coprinopsis cinerea produces (-)-α-cuprenene with high selectivity. | |||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | |||||||||||||
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EC | 4.2.3.6 | Relevance: 22.3% | ||||||||||||
Accepted name: | trichodiene synthase | |||||||||||||
Reaction: | (2E,6E)-farnesyl diphosphate = trichodiene + diphosphate | |||||||||||||
For diagram of biosynthesis of bicyclic sesquiterpenoids derived from bisabolyl cation, click here and for diagram of trichodiene and (–)-α-cuprenene biosynthesis, click here | ||||||||||||||
Other name(s): | trichodiene synthetase; sesquiterpene cyclase; trans,trans-farnesyl-diphosphate sesquiterpenoid-lyase | |||||||||||||
Systematic name: | (2E,6E)-farnesyl-diphosphate diphosphate-lyase (cyclizing, trichodiene-forming) | |||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 101915-76-8 | |||||||||||||
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EC | 1.14.13.104 | |||||||||||||
Transferred entry: | (+)-menthofuran synthase. Now EC 1.14.14.143, (+)-menthofuran synthase | |||||||||||||
EC | 1.3.99.25 | Relevance: 22.1% | ||||||||||||
Accepted name: | carvone reductase | |||||||||||||
Reaction: | (1) (+)-dihydrocarvone + acceptor = (–)-carvone + reduced acceptor (2) (–)-isodihydrocarvone + acceptor = (+)-carvone + reduced acceptor |
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For diagram of (–)-carvone catabolism, click here | ||||||||||||||
Glossary: | (+)-dihydrocarvone = (1S,4R)-menth-8-en-2-one (+)-isodihydrocarvone = (1S,4R)-menth-8-en-2-one (–)-carvone = (4R)-mentha-1(6),8-dien-6-one = (5R)-2-methyl-5-(prop-1-en-2-yl)cyclohex-2-en-1-one |
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Systematic name: | (+)-dihydrocarvone:acceptor 1,6-oxidoreductase | |||||||||||||
Comments: | This enzyme participates in the carveol and dihydrocarveol degradation pathway of the Gram-positive bacterium Rhodococcus erythropolis DCL14. The enzyme has not been purified, and requires an unknown cofactor, which is different from NAD+, NADP+ or a flavin. | |||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | |||||||||||||
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EC | 1.1.1.296 | Relevance: 21.9% | ||||||||||||
Accepted name: | dihydrocarveol dehydrogenase | |||||||||||||
Reaction: | menth-8-en-2-ol + NAD+ = menth-8-en-2-one + NADH + H+ | |||||||||||||
For diagram of (–)-carvone catabolism, click here | ||||||||||||||
Glossary: | (+)-dihydrocarveol = (1S,2S,4S)-menth-8-en-2-ol (+)-isodihydrocarveol = (1S,2S,4R)-menth-8-en-2-ol (+)-neoisodihydrocarveol = (1S,2R,4R)-menth-8-en-2-ol (–)-dihydrocarvone = (1S,4S)-menth-8-en-2-one (+)-isodihydrocarvone = (1S,4R)-menth-8-en-2-one |
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Other name(s): | carveol dehydrogenase (ambiguous) | |||||||||||||
Systematic name: | menth-8-en-2-ol:NAD+ oxidoreductase | |||||||||||||
Comments: | This enzyme from the Gram-positive bacterium Rhodococcus erythropolis DCL14 forms part of the carveol and dihydrocarveol degradation pathway. The enzyme accepts all eight stereoisomers of menth-8-en-2-ol as substrate, although some isomers are converted faster than others. The preferred substrates are (+)-neoisodihydrocarveol, (+)-isodihydrocarveol, (+)-dihydrocarveol and (–)-isodihydrocarveol. | |||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | |||||||||||||
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EC | 1.14.13.47 | |||||||||||||
Transferred entry: | (S)-limonene 3-monooxygenase. Now EC 1.14.14.99, (S)-limonene 3-monooxygenase | |||||||||||||
EC | 3.1.1.83 | Relevance: 20.7% | ||||||||||||
Accepted name: | monoterpene ε-lactone hydrolase | |||||||||||||
Reaction: | (1) isoprop(en)ylmethyloxepan-2-one + H2O = 6-hydroxyisoprop(en)ylmethylhexanoate (general reaction) (2) 4-isopropenyl-7-methyloxepan-2-one + H2O = 6-hydroxy-3-isopropenylheptanoate (3) 7-isopropyl-4-methyloxepan-2-one + H2O = 6-hydroxy-3,7-dimethyloctanoate |
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For diagram of (–)-carvone catabolism, click here and for diagram of menthol biosynthesis, click here | ||||||||||||||
Other name(s): | MLH | |||||||||||||
Systematic name: | isoprop(en)ylmethyloxepan-2-one lactonohydrolase | |||||||||||||
Comments: | The enzyme catalyses the ring opening of ε-lactones which are formed during degradation of dihydrocarveol by the Gram-positive bacterium Rhodococcus erythropolis DCL14. The enzyme also acts on ethyl caproate, indicating that it is an esterase with a preference for lactones (internal cyclic esters). The enzyme is not stereoselective. | |||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | |||||||||||||
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EC | 1.14.13.48 | |||||||||||||
Transferred entry: | (S)-limonene 6-monooxygenase. Now classified as EC 1.14.14.51, (S)-limonene 6-monooxygenase | |||||||||||||
EC | 1.14.13.49 | |||||||||||||
Transferred entry: | (S)-limonene 7-monooxygenase. Now classified as EC 1.14.14.52, (S)-limonene 7-monooxygenase | |||||||||||||
EC | 1.14.13.105 | Relevance: 17.5% | ||||||||||||
Accepted name: | monocyclic monoterpene ketone monooxygenase | |||||||||||||
Reaction: | (1) (–)-menthone + NADPH + H+ + O2 = (4R,7S)-7-isopropyl-4-methyloxepan-2-one + NADP+ + H2O (2) dihydrocarvone + NADPH + H+ + O2 = 4-isopropenyl-7-methyloxepan-2-one + NADP+ + H2O (3) (iso)-dihydrocarvone + NADPH + H+ + O2 = 6-isopropenyl-3-methyloxepan-2-one + NADP+ + H2O (4a) 1-hydroxymenth-8-en-2-one + NADPH + H+ + O2 = 7-hydroxy-4-isopropenyl-7-methyloxepan-2-one + NADP+ + H2O (4b) 7-hydroxy-4-isopropenyl-7-methyloxepan-2-one = 3-isopropenyl-6-oxoheptanoate (spontaneous) |
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For diagram of (–)-carvone catabolism, click here, for diagram of limonene catabolism, click here and for diagram of menthol biosynthesis, click here | ||||||||||||||
Other name(s): | 1-hydroxy-2-oxolimonene 1,2-monooxygenase; dihydrocarvone 1,2-monooxygenase; MMKMO | |||||||||||||
Systematic name: | (–)-menthone,NADPH:oxygen oxidoreductase | |||||||||||||
Comments: | A flavoprotein (FAD). This Baeyer-Villiger monooxygenase enzyme from the Gram-positive bacterium Rhodococcus erythropolis DCL14 has wide substrate specificity, catalysing the lactonization of a large number of monocyclic monoterpene ketones and substituted cyclohexanones [2]. Both (1R,4S)- and (1S,4R)-1-hydroxymenth-8-en-2-one are metabolized, with the lactone product spontaneously rearranging to form 3-isopropenyl-6-oxoheptanoate [1]. | |||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | |||||||||||||
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