|
Your query returned 3 entries. Printable version
EC | 1.14.13.186 | ||||
Transferred entry: | 20-oxo-5-O-mycaminosyltylactone 23-monooxygenase. Now EC 1.14.15.34, 20-oxo-5-O-mycaminosyltylactone 23-monooxygenase | ||||
EC | 1.14.15.34 | ||||
Accepted name: | 20-oxo-5-O-mycaminosyltylactone 23-monooxygenase | ||||
Reaction: | 20-oxo-5-O-β-mycaminosyltylactone + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ + O2 = 5-O-β-mycaminosyltylonolide + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O | ||||
For diagram of tylosin biosynthesis, click here | |||||
Glossary: | tylactone = (4R,5S,6S,7S,9R,11E,13E,15S,16R)-7,16-diethyl-4,6-dihydroxy-5,9,13,15-tetramethyl-1-oxacyclohexadeca-11,13-diene-2,10-dione α-D-mycaminose = 3-dimethylamino-3,6-dideoxy-α-D-glucopyranose tylonolide = 2-[(4R,5S,6S,7R,9R,11E,13E,15R,16R)-16-ethyl-4,6-dihydroxy-15-(hydroxymethyl)-5,9,13-trimethyl-2,10-dioxo-1-oxacyclohexadeca-11,13-dien-7-yl]acetaldehyde |
||||
Other name(s): | tylH1 (gene name) | ||||
Systematic name: | 20-oxo-5-O-β-mycaminosyltylactone,reduced ferredoxin:oxygen oxidoreductase (23-hydroxylating) | ||||
Comments: | A cytochrome P-450 (heme-thiolate) protein. Involved in the biosynthetic pathway of the macrolide antibiotic tylosin, which is produced by several species of Streptomyces bacteria. | ||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB | ||||
References: |
| ||||
EC | 2.4.1.316 | ||||
Accepted name: | tylactone mycaminosyltransferase | ||||
Reaction: | tylactone + dTDP-α-D-mycaminose = dTDP + 5-O-β-D-mycaminosyltylactone | ||||
For diagram of tylactone biosynthesis, click here | |||||
Glossary: | tylactone = (4R,5S,6S,7S,9R,11E,13E,15S,16R)-7,16-diethyl-4,6-dihydroxy-5,9,13,15-tetramethyloxacyclohexadeca-11,13-diene-2,10-dione dTDP-α-D-mycaminose = dTDP-3,6-dideoxy-3-dimethylamino-α-D-glucopyranose |
||||
Other name(s): | tylM2 (gene name) | ||||
Systematic name: | dTDP-α-D-mycaminose:tylactone 5-O-β-D-mycaminosyltransferase | ||||
Comments: | The enzyme participates in the biosynthetic pathway of the macrolide antibiotic tylosin, which is produced by several species of Streptomyces bacteria. Activity is significantly enhanced by the presence of an accessory protein encoded by the tylM3 gene. | ||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||||
References: |
| ||||