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Your query returned 2 entries. Printable version
EC | 2.3.1.211 | ||
Accepted name: | bisdemethoxycurcumin synthase | ||
Reaction: | 2 4-coumaroyl-CoA + malonyl-CoA + H2O = 3 CoA + bisdemethoxycurcumin + 2 CO2 | ||
For diagram of curcumin biosynthesis, click here | |||
Glossary: | bisdemethoxycurcumin = (1E,6E)-5-hydroxy-1,7-bis(4-hydroxyphenyl)hepta-1,4,6-trien-3-one | ||
Other name(s): | CUS; curcuminoid synthase (ambiguous) | ||
Systematic name: | 4-coumaroyl-CoA:malonyl-CoA 4-coumaryltransferase (bisdemethoxycurcumin-forming) | ||
Comments: | A polyketide synthase characterized from the plant Oryza sativa (rice) that catalyses the formation of the C6-C7-C6 diarylheptanoid scaffold of bisdemethoxycurcumin. Unlike the process in the plant Curcuma longa (turmeric), where the conversion is carried out via a diketide intermediate by two different enzymes (EC 2.3.1.218, phenylpropanoylacetyl-CoA synthase and EC 2.3.1.217, curcumin synthase), the diketide intermediate formed by this enzyme remains within the enzyme’s cavity and is not released to the environment. | ||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB | ||
References: |
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EC | 2.3.1.219 | ||
Accepted name: | demethoxycurcumin synthase | ||
Reaction: | (1) 4-coumaroyl-CoA + feruloylacetyl-CoA + H2O = 2 CoA + demethoxycurcumin + CO2 (2) 4-coumaroyl-CoA + (4-coumaroyl)acetyl-CoA + H2O = 2 CoA + bisdemethoxycurcumin + CO2 |
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For diagram of curcumin biosynthesis, click here | |||
Glossary: | demethoxycurcumin = (1E,6E)-5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl)hepta-1,4,6-trien-3-one bisdemethoxycurcumin = (1E,6E)-5-hydroxy-1,7-bis(4-hydroxyphenyl)hepta-1,4,6-trien-3-one feruloylacetyl-CoA = feruloyl-diketide-CoA (4-coumaroyl)acetyl-CoA = 4-coumaroyl-diketide-CoA |
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Other name(s): | CURS3 | ||
Systematic name: | 4-coumaroyl-CoA:feruloylacetyl-CoA feruloyltransferase (demethoxycurcumin-forming) | ||
Comments: | A polyketide synthase from the plant Curcuma longa (turmeric). Three isoforms exist, CURS1, CURS2 and CURS3. While CURS1 and CURS2 prefer feruloyl-CoA as a starter substrate (cf. EC 2.3.1.217, curcumin synthase), CURS3 can accept 4-coumaroyl-CoA equally well [1]. | ||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||
References: |
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