EC |
1.2.1.65 |
Accepted name: |
salicylaldehyde dehydrogenase |
Reaction: |
salicylaldehyde + NAD+ + H2O = salicylate + NADH + 2 H+ |
Glossary: |
salicylaldehyde = 2-hydroxybenzaldehyde |
Systematic name: |
salicylaldehyde:NAD+ oxidoreductase |
Comments: |
Involved in the naphthalene degradation pathway in some bacteria. |
Links to other databases: |
BRENDA, EAWAG-BBD, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 55354-34-2 |
References: |
1. |
Eaton, R. and Chapman, P.J. Bacterial metabolism of naphthalene: construction and use of recombinant bacteria to study ring cleavage of 1,2-dihydroxynaphthalene and subsequent reactions. J. Bacteriol. 174 (1992) 7542–7554. [DOI] [PMID: 1447127] |
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[EC 1.2.1.65 created 2000, modified 2011] |
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EC |
4.1.2.45 |
Accepted name: |
trans-o-hydroxybenzylidenepyruvate hydratase-aldolase |
Reaction: |
(3E)-4-(2-hydroxyphenyl)-2-oxobut-3-enoate + H2O = salicylaldehyde + pyruvate |
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For diagram of naphthalene metabolism, click here |
Glossary: |
(3E)-4-(2-hydroxyphenyl)-2-oxobut-3-enoate = (E)-2′-hydroxybenzylidenepyruvate
salicylaldehyde = 2-hydroxybenzaldehyde |
Other name(s): |
2′-hydroxybenzalpyruvate aldolase; NsaE; tHBPA hydratase-aldolase |
Systematic name: |
(3E)-4-(2-hydroxyphenyl)-2-oxobut-3-enoate hydro-lyase |
Comments: |
This enzyme is involved in naphthalene degradation. The enzyme catalyses a retro-aldol reaction in vitro, and it accepts a broad range of aldehydes and 4-substituted 2-oxobut-3-enoates as substrates [4]. |
Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB |
References: |
1. |
Kuhm, A.E., Knackmuss, H.J. and Stolz, A. Purification and properties of 2′-hydroxybenzalpyruvate aldolase from a bacterium that degrades naphthalenesulfonates. J. Biol. Chem. 268 (1993) 9484–9489. [PMID: 8486638] |
2. |
Keck, A., Conradt, D., Mahler, A., Stolz, A., Mattes, R. and Klein, J. Identification and functional analysis of the genes for naphthalenesulfonate catabolism by Sphingomonas xenophaga BN6. Microbiology 152 (2006) 1929–1940. [DOI] [PMID: 16804169] |
3. |
Eaton, R.W. Organization and evolution of naphthalene catabolic pathways: sequence of the DNA encoding 2-hydroxychromene-2-carboxylate isomerase and trans-o-hydroxybenzylidenepyruvate hydratase-aldolase from the NAH7 plasmid. J. Bacteriol. 176 (1994) 7757–7762. [DOI] [PMID: 8002605] |
4. |
Eaton, R.W. trans-o-Hydroxybenzylidenepyruvate hydratase-aldolase as a biocatalyst. Appl. Environ. Microbiol. 66 (2000) 2668–2672. [DOI] [PMID: 10831455] |
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[EC 4.1.2.45 created 2010, modified 2011] |
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