| EC |
1.1.1.51 |
| Accepted name: |
3(or 17)β-hydroxysteroid dehydrogenase |
| Reaction: |
testosterone + NAD(P)+ = androstenedione + NAD(P)H + H+ |
| Glossary: |
androstenedione = androst-4-ene-3,17-dione |
| Other name(s): |
β-hydroxy steroid dehydrogenase; 17-ketoreductase; 17β-hydroxy steroid dehydrogenase; 3β-hydroxysteroid dehydrogenase; 3β-hydroxy steroid dehydrogenase |
| Systematic name: |
3(or 17)β-hydroxysteroid:NAD(P)+ oxidoreductase |
| Comments: |
Also acts on other 3β- or 17β-hydroxysteroids. cf. EC 1.1.1.209 3(or 17)α-hydroxysteroid dehydrogenase. |
| Links to other databases: |
BRENDA, EAWAG-BBD, EXPASY, GTD, KEGG, MetaCyc, PDB, CAS registry number: 9015-81-0 |
| References: |
| 1. |
Dahm, K. and Breuer, H. Anreicherung einer 17β-hydroxysteroid:NAD(P)-oxydoreduktase aus der Nebenniere der Ratte. Hoppe-Seyler's Z. Physiol. Chem. 336 (1964) 63–68. [PMID: 14214322] |
| 2. |
Lynn, W.S. and Brown, R.H. The conversion of progesterone to androgens by testes. J. Biol. Chem. 232 (1958) 1015–1030. [PMID: 13549484] |
| 3. |
Marcus, P.I. and Talalay, P. Induction and purification of α- and β-hydroxysteroid dehydrogenases. J. Biol. Chem. 218 (1956) 661–674. [PMID: 13295221] |
| 4. |
Schultz, R.M., Groman, F.V. and Engel, L.L. 3(17)β-Hydroxysteroid dehydrogenase of Pseudomonas testosteroni. A convenient purification and demonstration of multiple molecular forms. J. Biol. Chem. 252 (1977) 3775–3783. [PMID: 193845] |
| 5. |
Talalay, P. and Dobson, M.M. Purification and properties of a α-hydroxysteroid dehydrogenase. J. Biol. Chem. 205 (1953) 823–837. [PMID: 13129261] |
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| [EC 1.1.1.51 created 1961] |
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