EC |
2.6.1.26 |
Accepted name: |
thyroid-hormone transaminase |
Reaction: |
L-3,5,3′-triiodothyronine + 2-oxoglutarate = 3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]-2-oxopropanoate + L-glutamate |
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For diagram of reaction, click here and for mechanism, click here |
Other name(s): |
3,5-dinitrotyrosine transaminase; thyroid hormone aminotransferase |
Systematic name: |
L-3,5,3′-triiodothyronine:2-oxoglutarate aminotransferase |
Comments: |
A pyridoxal-phosphate protein. Acts on monoiodotyrosine, diiodotyrosine, triiodothyronine, thyroxine and dinitrotyrosine (unlike EC 2.6.1.24 diiodotyrosine transaminase, which does not act on dinitrotyrosine). Pyruvate or oxaloacetate can act as acceptors. |
Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 51004-29-6 |
References: |
1. |
Soffer, R.L., Hechtman, P. and Savage, M. L-Triiodothyronine aminotransferase. J. Biol. Chem. 248 (1973) 1224–1230. [PMID: 4686924] |
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[EC 2.6.1.26 created 1972] |
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