| EC |
3.5.5.1 |
| Accepted name: |
nitrilase |
| Reaction: |
a nitrile + 2 H2O = a carboxylate + NH3 |
| Other name(s): |
acetonitrilase; benzonitrilase |
| Systematic name: |
nitrile aminohydrolase |
| Comments: |
Acts on a wide range of aromatic nitriles including (indol-3-yl)acetonitrile, and also on some aliphatic nitriles, and on the corresponding acid amides. cf. EC 4.2.1.84 nitrile hydratase. |
| Links to other databases: |
BRENDA, EAWAG-BBD, EXPASY, Gene, KEGG, MetaCyc, PDB, CAS registry number: 9024-90-2 |
| References: |
| 1. |
Harper, D.B. Microbial metabolism of aromatic nitriles. Enzymology of C-N cleavage by Nocardia sp. (rhodochrous group) N.C.I.B. 11216. Biochem. J. 165 (1977) 309–319. [PMID: 21655] |
| 2. |
Thimann, K.V. and Mahadevan, S. Nitrilase. I. Occurrence, preparation, and general properties of the enzyme. Arch. Biochem. Biophys. 105 (1964) 133–141. [DOI] [PMID: 14165487] |
| 3. |
Pace, H.C. and Brenner, C. The nitrilase superfamily: classification, structure and function. Genome Biol. 2 (2001) 0001.. [PMID: 11380987] |
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| [EC 3.5.5.1 created 1965, modified 1989] |
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