ExplorEnz: EC 4.2.1.142

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4.2.1.142

Accepted name:

5′-oxoaverantin cyclase

Reaction:

5′-oxoaverantin = (1′S,5′S)-averufin + H₂O

For diagram of aflatoxin biosynthesis (part 1), click here

Glossary:

5′-oxoaverantin = 1,3,6,8-tetrahydroxy-2-[(1S)-1-hydroxy-5-oxohexyl]anthracene-9,10-dione
averufin = 7,9,11-trihydroxy-2-methyl-3,4,5,6-tetrahydro-2,6-epoxy-2H-anthra[2,3-b]oxocin-8,13-dione

Other name(s):

OAVN cyclase; 5′-oxoaverantin hydro-lyase [(2′S,5′S)-averufin forming]

Systematic name:

5′-oxoaverantin hydro-lyase [(1′S,5′S)-averufin-forming]

Comments:

Isolated from the aflatoxin-producing mold Aspergillus parasiticus. The enzyme also catalyses the conversion of versiconal to versicolorin B (EC 4.2.1.143, versicolorin B synthase). Involved in aflatoxin biosynthesis.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc

References:

1.	Sakuno, E., Yabe, K. and Nakajima, H. Involvement of two cytosolic enzymes and a novel intermediate, 5′-oxoaverantin, in the pathway from 5′-hydroxyaverantin to averufin in aflatoxin biosynthesis. Appl. Environ. Microbiol. 69 (2003) 6418–6426. [DOI] [PMID: 14602595]
2.	Sakuno, E., Wen, Y., Hatabayashi, H., Arai, H., Aoki, C., Yabe, K. and Nakajima, H. Aspergillus parasiticus cyclase catalyzes two dehydration steps in aflatoxin biosynthesis. Appl. Environ. Microbiol. 71 (2005) 2999–3006. [DOI] [PMID: 15932995]

[EC 4.2.1.142 created 2013]