| EC |
4.2.1.94 |
| Accepted name: |
scytalone dehydratase |
| Reaction: |
scytalone = 1,3,8-trihydroxynaphthalene + H2O |
| Other name(s): |
scytalone 7,8-hydro-lyase |
| Systematic name: |
scytalone 7,8-hydro-lyase (1,3,8-trihydroxynaphthalene-forming) |
| Comments: |
Involved, with EC 1.1.1.252 tetrahydroxynaphthalene reductase, in the biosynthesis of melanin in pathogenic fungi. |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB, CAS registry number: 118901-79-4 |
| References: |
| 1. |
Butler, M.J., Lazarovits, G., Higgins, V.J. and Lachance, M.-A. Partial-purification and characterization of a dehydratase associated with the pentaketide melanogenesis pathway of Phaeococcomyces sp and other fungi. Exp. Mycol. 12 (1988) 367–376. |
| 2. |
Tajima, S., Kubo, Y., Furusawa, I. and Shishiyama, J. Purification of a melanin biosynthetic enzyme converting scytalone to 1,3,8-trihydroxynaphthalene from Cochliobolus miyabeanus. Exp. Mycol. 13 (1989) 69. |
| 3. |
Wheeler, M.H. and Greenblatt, G.A. The inhibition of melanin biosynthetic reactions in Pyricularia oryzae by compounds that prevent rice blast disease. Exp. Mycol. 12 (1988) 151–160. |
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| [EC 4.2.1.94 created 1992] |
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