ExplorEnz: Information
The Enzyme Database


Links to Other Databases

There are links from each entry to other related databases, each of which uses the IUBMB Enzyme List for enzyme identification. Every effort is made to coordinate the Enzyme entries, but the responsibility for any discrepancies between ExplorEnz and the entries in the linked databases rests with them alone, Brief descriptions of each follow.

BRENDA (http://www.brenda-enzymes.org/)
This is a comprehensive enzyme information database that provides functional data on enzyme stabilities, specificities, kinetic parameters, cofactors, inhibitors and activators in different species, with relevant references.

EXPASY (http://www.expasy.org/enzyme/)
This provides access to scientific databases and software tools in different areas of life sciences including proteomics, genomics, phylogeny, systems biology, population genetics, transcriptomics etc. Part of the EXPASY database is ENZYME, which contains pointers to the SWISS-PROT protein sequence entries that correspond to the enzyme any) and to any human disease(s)that are associated with a deficiency of the enzyme Enzyme entries are linked to a digitized version of the Roche Applied Science "Biochemical Pathways" wall chart which allows the metabolic role(s) of the enzyme to be identified.

GTD (http://xpdb.nist.gov/enzyme_thermodynamics/)
A database of the Thermodynamics of Enzyme-Catalysed Reactions maintained by the National Institute of Standards and Technology, USA. The data comprise equilibrium and calorimetric values determined under defined conditions and with the relevant literature references. Each entry shows the method of measurement and conditions under which it was obtained and any that have been applied to it.

KEGG (http://www.genome.ad.jp/kegg/)
KEGG (Kyoto Encyclopedia of Genes and Genomes) is a comprehensive set of databases linking genomes to life and the environment. It contain information on molecular and cellular biology in terms of pathways and molecular interactions. It also provides links genome sequencing data. The KEGG database also provides metabolic pathway maps and regulatory pathways maps, which can be viewed in terms of a specific organism. KEGG provides enzyme data with links to pathways, genes and diseases (OMIM database), motif and PDB (Protein Data Bank) structures.

MEROPS (http://www.merops.ac.uk/)
The MEROPS database is an integrated resource for information on peptidases (EC subclass 3.4). The underlying classification assigns the peptidases to families on the basis of amino acid sequence similarities, and then groups the families in clans according to three-dimensional structures. Information provided in the database includes amino acid and nucleotide sequence identifiers, gene names and loci, images of three dimensional molecular structures, alignments of amino acid sequences, phylogenetic trees, and alignments of matching expressed sequence tags. Data for the catalytic activities of the peptidases include a specificity search, inhibitors and comments on biological functions of the enzymes.

MetaCyc (http://metacyc.org/)
MetaCyc is a database of experimentally elucidated metabolic pathways. It contains more than 2300 pathways from more than 2600 different organisms and is curated from the scientific experimental literature. Enzyme-catalysed reactions are shown in terms the structural formulae of the substrates and products and are linked to the appropriate metabolic pathways.

PDB (http://www.rcsb.org/pdb/)
The PDB (Protein Data Bank) is a repository of 3-D macromolecular structural data primarily determined experimentally by X-ray crystallography and NMR. The link is to an index of enzymes in the PDB database.

EAWAG-BBD (http://eawag-bbd.ethz.ch/)
EAWAG-BBD (Eawag Biocatalysis/Biodegradation Database; formerly UM-BBD) contains information on microbial biocatalytic reactions and biodegradation pathways, primarily for xenobiotics. The EAWAG-BBD provides information on microbial enzyme-catalysed reactions that are important for that area of biotechnology. Individual reactions and metabolic pathways are presented with information on the starting and intermediate chemical compounds, the organisms that transform the compounds, the enzymes, and the relevant genes.

CAS registry number The CAS (Chemical Abstracts Service) registry number is a unique identifier which can be used in for searching the Chemical Abstracts database. The registry file provides a list of synonyms and the main database gives references that refer to the enzyme.

These show the mechanism of specific enzyme reactions and /or pathways in which they are involved. They were developed by Dr H.B.F. Dixon and Prof G.P. Moss and are now maintained and developed by Prof Moss.