The Enzyme Database

Table of Contents

The enzymes in this section of the database are organized as you would find them in the Enzyme-Nomenclature book. Click [+] to expand, and [–] to collapse, any section. Clicking on a heading will open popup window with information on that class, subclass or sub-subclass.

For a fully expanded list of the classes, subclasses and sub-subclasses, click here

[+subclass]. [+sub-subclass]. [+serial]

EC 1 [+]   
EC 2 [+]   
EC 3 [+]   
EC 4 []   
    EC 4.1  [+]      
    EC 4.2  []      
        EC 4.2.1       []    Hydro-lyases 
                EC 4.2.1.1                      carbonic anhydrase 
                EC 4.2.1.2                      fumarate hydratase 
                EC 4.2.1.3                      aconitate hydratase 
                EC 4.2.1.4                      citrate dehydratase. Now known to be a partial reaction catalysed by EC 4.2.1.3, aconitate hydratase.  
                EC 4.2.1.5                      arabinonate dehydratase 
                EC 4.2.1.6                      galactonate dehydratase 
                EC 4.2.1.7                      altronate dehydratase 
                EC 4.2.1.8                      mannonate dehydratase 
                EC 4.2.1.9                      dihydroxy-acid dehydratase 
                EC 4.2.1.10                      3-dehydroquinate dehydratase 
                EC 4.2.1.11                      phosphopyruvate hydratase 
                EC 4.2.1.12                      phosphogluconate dehydratase 
                EC 4.2.1.13                      L-serine dehydratase. Now EC 4.3.1.17, L-serine ammonia-lyase 
                EC 4.2.1.14                      D-serine dehydratase. Now EC 4.3.1.18, D-serine ammonia-lyase 
                EC 4.2.1.15                       homoserine dehydratase. Identical with EC 4.4.1.1 cystathionine γ-lyase 
                EC 4.2.1.16                      threonine dehydratase. Now EC 4.3.1.19, threonine ammonia-lyase 
                EC 4.2.1.17                      enoyl-CoA hydratase 
                EC 4.2.1.18                      methylglutaconyl-CoA hydratase 
                EC 4.2.1.19                      imidazoleglycerol-phosphate dehydratase 
                EC 4.2.1.20                      tryptophan synthase 
                EC 4.2.1.21                       cystathionine β-synthase. Now EC 4.2.1.22 cystathionine β-synthase 
                EC 4.2.1.22                      cystathionine β-synthase 
                EC 4.2.1.23                       methylcysteine synthase. The reaction was due to a side-reaction of EC 4.2.1.22 cystathionine β-synthase 
                EC 4.2.1.24                      porphobilinogen synthase 
                EC 4.2.1.25                      L-arabinonate dehydratase 
                EC 4.2.1.26                      aminodeoxygluconate dehydratase. This enzyme was transferred to EC 4.3.1.21, aminodeoxygluconate ammonia-lyase, which has since been deleted. The enzyme is identical to EC 4.3.1.9, glucosaminate ammonia-lyase 
                EC 4.2.1.27                      acetylenecarboxylate hydratase 
                EC 4.2.1.28                      propanediol dehydratase 
                EC 4.2.1.29                      indoleacetaldoxime dehydratase. Now EC 4.99.1.6, indoleacetaldoxime dehydratase. The enzyme was classified incorrectly as a C-O lyase when the bond broken is a N-O bond 
                EC 4.2.1.30                      glycerol dehydratase 
                EC 4.2.1.31                      maleate hydratase 
                EC 4.2.1.32                      L(+)-tartrate dehydratase 
                EC 4.2.1.33                      3-isopropylmalate dehydratase 
                EC 4.2.1.34                      (S)-2-methylmalate dehydratase 
                EC 4.2.1.35                      (R)-2-methylmalate dehydratase 
                EC 4.2.1.36                      homoaconitate hydratase 
                EC 4.2.1.37                      trans-epoxysuccinate hydratase. Now EC 3.3.2.4, trans-epoxysuccinate hydrolase 
                EC 4.2.1.38                      erythro-3-hydroxyaspartate dehydratase. Now EC 4.3.1.20, erythro-3-hydroxyaspartate ammonia-lyase 
                EC 4.2.1.39                      gluconate dehydratase 
                EC 4.2.1.40                      glucarate dehydratase 
                EC 4.2.1.41                      5-dehydro-4-deoxyglucarate dehydratase 
                EC 4.2.1.42                      galactarate dehydratase 
                EC 4.2.1.43                      2-dehydro-3-deoxy-L-arabinonate dehydratase 
                EC 4.2.1.44                      myo-inosose-2 dehydratase 
                EC 4.2.1.45                      CDP-glucose 4,6-dehydratase 
                EC 4.2.1.46                      dTDP-glucose 4,6-dehydratase 
                EC 4.2.1.47                      GDP-mannose 4,6-dehydratase 
                EC 4.2.1.48                      D-glutamate cyclase 
                EC 4.2.1.49                      urocanate hydratase 
                EC 4.2.1.50                      pyrazolylalanine synthase 
                EC 4.2.1.51                      prephenate dehydratase 
                EC 4.2.1.52                      dihydrodipicolinate synthase. Now EC 4.3.3.7, 4-hydroxy-2,3,4,5-tetrahydrodipicolinate synthase. 
                EC 4.2.1.53                      oleate hydratase 
                EC 4.2.1.54                      lactoyl-CoA dehydratase 
                EC 4.2.1.55                      3-hydroxybutyryl-CoA dehydratase 
                EC 4.2.1.56                      itaconyl-CoA hydratase 
                EC 4.2.1.57                      isohexenylglutaconyl-CoA hydratase 
                EC 4.2.1.58                      crotonoyl-[acyl-carrier-protein] hydratase. The reaction described is covered by EC 4.2.1.59. 
                EC 4.2.1.59                      3-hydroxyacyl-[acyl-carrier-protein] dehydratase 
                EC 4.2.1.60                      3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase. The reaction described is covered by EC 4.2.1.59. 
                EC 4.2.1.61                      3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase. The reaction described is covered by EC 4.2.1.59. 
                EC 4.2.1.62                      5α-hydroxysteroid dehydratase 
                EC 4.2.1.63                      epoxide hydratase. Now known to comprise two enzymes, microsomal epoxide hydrolase (EC 3.3.2.9) and soluble epoxide hydrolase (EC 3.3.2.10) 
                EC 4.2.1.64                      arene-oxide hydratase. Now known to comprise two enzymes, microsomal epoxide hydrolase (EC 3.3.2.9) and soluble epoxide hydrolase (EC 3.3.2.10) 
                EC 4.2.1.65                      3-cyanoalanine hydratase 
                EC 4.2.1.66                      cyanide hydratase 
                EC 4.2.1.67                      D-fuconate dehydratase 
                EC 4.2.1.68                      L-fuconate dehydratase 
                EC 4.2.1.69                      cyanamide hydratase 
                EC 4.2.1.70                      pseudouridylate synthase 
                EC 4.2.1.71                       acetylenecarboxylate hydratase. This enzyme is identical to EC 4.2.1.27, acetylenecarboxylate hydratase 
                EC 4.2.1.72                      acetylenedicarboxylate hydratase. Now EC 4.1.1.78, acetylenedicarboxylate decarboxylase 
                EC 4.2.1.73                      protoaphin-aglucone dehydratase (cyclizing) 
                EC 4.2.1.74                      long-chain-enoyl-CoA hydratase 
                EC 4.2.1.75                      uroporphyrinogen-III synthase 
                EC 4.2.1.76                      UDP-glucose 4,6-dehydratase 
                EC 4.2.1.77                      trans-L-3-hydroxyproline dehydratase 
                EC 4.2.1.78                      (S)-norcoclaurine synthase 
                EC 4.2.1.79                      2-methylcitrate dehydratase 
                EC 4.2.1.80                      2-oxopent-4-enoate hydratase 
                EC 4.2.1.81                      D(-)-tartrate dehydratase 
                EC 4.2.1.82                      xylonate dehydratase 
                EC 4.2.1.83                      4-oxalomesaconate hydratase 
                EC 4.2.1.84                      nitrile hydratase 
                EC 4.2.1.85                      dimethylmaleate hydratase 
                EC 4.2.1.86                       16-dehydroprogesterone hydratase (reaction is identical to that of EC 4.2.1.98, 16α-hydroxyprogesterone dehydratase) 
                EC 4.2.1.87                      octopamine dehydratase 
                EC 4.2.1.88                      synephrine dehydratase 
                EC 4.2.1.89                      carnitine dehydratase. The activity has now been shown to be due to EC 2.8.3.21, L-carnitine CoA-transferase and EC 4.2.1.149, crotonobetainyl-CoA hydratase. 
                EC 4.2.1.90                      L-rhamnonate dehydratase 
                EC 4.2.1.91                      arogenate dehydratase 
                EC 4.2.1.92                      hydroperoxide dehydratase 
                EC 4.2.1.93                      ATP-dependent NAD(P)H-hydrate dehydratase 
                EC 4.2.1.94                      scytalone dehydratase 
                EC 4.2.1.95                      kievitone hydratase 
                EC 4.2.1.96                      4a-hydroxytetrahydrobiopterin dehydratase 
                EC 4.2.1.97                      phaseollidin hydratase 
                EC 4.2.1.98                      16α-hydroxyprogesterone dehydratase 
                EC 4.2.1.99                      2-methylisocitrate dehydratase 
                EC 4.2.1.100                      cyclohexa-1,5-dienecarbonyl-CoA hydratase 
                EC 4.2.1.101                      trans-feruloyl-CoA hydratase 
                EC 4.2.1.102                      cyclohexa-1,5-dienecarbonyl-CoA hydratase. Now EC 4.2.1.100, cyclohexa-1,5-dienecarbonyl-CoA hydratase 
                EC 4.2.1.103                      cyclohexyl-isocyanide hydratase 
                EC 4.2.1.104                      cyanase 
                EC 4.2.1.105                      2-hydroxyisoflavanone dehydratase 
                EC 4.2.1.106                      bile-acid 7α-dehydratase 
                EC 4.2.1.107                      3α,7α,12α-trihydroxy-5β-cholest-24-enoyl-CoA hydratase 
                EC 4.2.1.108                      ectoine synthase 
                EC 4.2.1.109                      methylthioribulose 1-phosphate dehydratase 
                EC 4.2.1.110                      aldos-2-ulose dehydratase 
                EC 4.2.1.111                      1,5-anhydro-D-fructose dehydratase 
                EC 4.2.1.112                      acetylene hydratase 
                EC 4.2.1.113                      o-succinylbenzoate synthase 
                EC 4.2.1.114                      methanogen homoaconitase 
                EC 4.2.1.115                      UDP-N-acetylglucosamine 4,6-dehydratase (configuration-inverting) 
                EC 4.2.1.116                      3-hydroxypropionyl-CoA dehydratase 
                EC 4.2.1.117                      2-methylcitrate dehydratase (2-methyl-trans-aconitate forming) 
                EC 4.2.1.118                      3-dehydroshikimate dehydratase 
                EC 4.2.1.119                      enoyl-CoA hydratase 2 
                EC 4.2.1.120                      4-hydroxybutanoyl-CoA dehydratase 
                EC 4.2.1.121                      colneleate synthase 
                EC 4.2.1.122                      tryptophan synthase (indole-salvaging) 
                EC 4.2.1.123                      tetrahymanol synthase 
                EC 4.2.1.124                      arabidiol synthase 
                EC 4.2.1.125                      dammarenediol II synthase 
                EC 4.2.1.126                      N-acetylmuramic acid 6-phosphate etherase 
                EC 4.2.1.127                      linalool dehydratase 
                EC 4.2.1.128                      lupan-3β,20-diol synthase 
                EC 4.2.1.129                      squalene—hopanol cyclase 
                EC 4.2.1.130                      D-lactate dehydratase 
                EC 4.2.1.131                      carotenoid 1,2-hydratase 
                EC 4.2.1.132                      2-hydroxyhexa-2,4-dienoate hydratase 
                EC 4.2.1.133                      copal-8-ol diphosphate hydratase 
                EC 4.2.1.134                      very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 
                EC 4.2.1.135                      UDP-N-acetylglucosamine 4,6-dehydratase (configuration-retaining) 
                EC 4.2.1.136                      ADP-dependent NAD(P)H-hydrate dehydratase 
                EC 4.2.1.137                      sporulenol synthase 
                EC 4.2.1.138                      (+)-caryolan-1-ol synthase 
                EC 4.2.1.139                      medicarpin synthase 
                EC 4.2.1.140                      gluconate/galactonate dehydratase  
                EC 4.2.1.141                      2-dehydro-3-deoxy-D-arabinonate dehydratase  
                EC 4.2.1.142                      5′-oxoaverantin cyclase 
                EC 4.2.1.143                      versicolorin B synthase 
                EC 4.2.1.144                      3-amino-5-hydroxybenzoate synthase 
                EC 4.2.1.145                      capreomycidine synthase 
                EC 4.2.1.146                      L-galactonate dehydratase 
                EC 4.2.1.147                      5,6,7,8-tetrahydromethanopterin hydro-lyase 
                EC 4.2.1.148                      2-methylfumaryl-CoA hydratase 
                EC 4.2.1.149                      crotonobetainyl-CoA hydratase 
                EC 4.2.1.150                      short-chain-enoyl-CoA hydratase 
                EC 4.2.1.151                      chorismate dehydratase 
                EC 4.2.1.152                      hydroperoxy icosatetraenoate dehydratase 
                EC 4.2.1.153                      3-methylfumaryl-CoA hydratase 
                EC 4.2.1.154                      tetracenomycin F2 cyclase 
                EC 4.2.1.155                      (methylthio)acryloyl-CoA hydratase 
                EC 4.2.1.156                      L-talarate dehydratase 
                EC 4.2.1.157                      (R)-2-hydroxyisocaproyl-CoA dehydratase 
                EC 4.2.1.158                      galactarate dehydratase (D-threo-forming) 
                EC 4.2.1.159                      dTDP-4-dehydro-6-deoxy-α-D-glucopyranose 2,3-dehydratase 
                EC 4.2.1.160                      2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one isomerase/dehydratase 
                EC 4.2.1.161                      bisanhydrobacterioruberin hydratase 
                EC 4.2.1.162                      6-deoxy-6-sulfo-D-gluconate dehydratase 
                EC 4.2.1.163                      2-oxo-hept-4-ene-1,7-dioate hydratase 
                EC 4.2.1.164                      dTDP-4-dehydro-2,6-dideoxy-D-glucose 3-dehydratase 
                EC 4.2.1.165                      chlorophyllide a 31-hydratase 
                EC 4.2.1.166                      phosphinomethylmalate isomerase 
                EC 4.2.1.167                      (R)-2-hydroxyglutaryl-CoA dehydratase 
                EC 4.2.1.168                      GDP-4-dehydro-6-deoxy-α-D-mannose 3-dehydratase 
                EC 4.2.1.169                      3-vinyl bacteriochlorophyllide d 31-hydratase 
                EC 4.2.1.170                      2-(ω-methylthio)alkylmalate dehydratase 
                EC 4.2.1.171                      cis-L-3-hydroxyproline dehydratase 
                EC 4.2.1.172                      trans-4-hydroxy-L-proline dehydratase 
                EC 4.2.1.173                      ent-8α-hydroxylabd-13-en-15-yl diphosphate synthase 
                EC 4.2.1.174                      peregrinol diphosphate synthase 
        EC 4.2.2       [+]    Acting on polysaccharides 
        EC 4.2.3       [+]    Acting on phosphates 
        EC 4.2.99       [+]    Other carbon-oxygen lyases 
    EC 4.3  [+]      
    EC 4.4  [+]      
    EC 4.5  [+]      
    EC 4.6  [+]      
    EC 4.7  [+]      
    EC 4.99  [+]      
EC 5 [+]   
EC 6 [+]   


© 2001-2018 IUBMB