The Enzyme Database

Table of Contents

The enzymes in this section of the database are organized as you would find them in the Enzyme-Nomenclature book. Click [+] to expand, and [–] to collapse, any section. Clicking on a heading will open popup window with information on that class, subclass or sub-subclass.

For a fully expanded list of the classes, subclasses and sub-subclasses, click here

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EC 1 [+]   
    EC 1.1  [+]      
        EC 1.1.1       []    With NAD+ or NADP+ as acceptor 
                EC 1.1.1.1                      alcohol dehydrogenase 
                EC 1.1.1.2                      alcohol dehydrogenase (NADP+) 
                EC 1.1.1.3                      homoserine dehydrogenase 
                EC 1.1.1.4                      (R,R)-butanediol dehydrogenase 
                EC 1.1.1.5                      acetoin dehydrogenase. Now EC 1.1.1.303, diacetyl reductase [(R)-acetoin forming] and EC 1.1.1.304, diacetyl reductase [(S)-acetoin forming] 
                EC 1.1.1.6                      glycerol dehydrogenase 
                EC 1.1.1.7                      propanediol-phosphate dehydrogenase 
                EC 1.1.1.8                      glycerol-3-phosphate dehydrogenase (NAD+) 
                EC 1.1.1.9                      D-xylulose reductase 
                EC 1.1.1.10                      L-xylulose reductase 
                EC 1.1.1.11                      D-arabinitol 4-dehydrogenase 
                EC 1.1.1.12                      L-arabinitol 4-dehydrogenase 
                EC 1.1.1.13                      L-arabinitol 2-dehydrogenase 
                EC 1.1.1.14                      L-iditol 2-dehydrogenase 
                EC 1.1.1.15                      D-iditol 2-dehydrogenase 
                EC 1.1.1.16                      galactitol 2-dehydrogenase 
                EC 1.1.1.17                      mannitol-1-phosphate 5-dehydrogenase 
                EC 1.1.1.18                      inositol 2-dehydrogenase 
                EC 1.1.1.19                      glucuronate reductase 
                EC 1.1.1.20                      glucuronolactone reductase 
                EC 1.1.1.21                      aldehyde reductase 
                EC 1.1.1.22                      UDP-glucose 6-dehydrogenase 
                EC 1.1.1.23                      histidinol dehydrogenase 
                EC 1.1.1.24                      quinate dehydrogenase 
                EC 1.1.1.25                      shikimate dehydrogenase 
                EC 1.1.1.26                      glyoxylate reductase 
                EC 1.1.1.27                      L-lactate dehydrogenase 
                EC 1.1.1.28                      D-lactate dehydrogenase 
                EC 1.1.1.29                      glycerate dehydrogenase 
                EC 1.1.1.30                      3-hydroxybutyrate dehydrogenase 
                EC 1.1.1.31                      3-hydroxyisobutyrate dehydrogenase 
                EC 1.1.1.32                      mevaldate reductase 
                EC 1.1.1.33                      mevaldate reductase (NADPH) 
                EC 1.1.1.34                      hydroxymethylglutaryl-CoA reductase (NADPH) 
                EC 1.1.1.35                      3-hydroxyacyl-CoA dehydrogenase 
                EC 1.1.1.36                      acetoacetyl-CoA reductase 
                EC 1.1.1.37                      malate dehydrogenase 
                EC 1.1.1.38                      malate dehydrogenase (oxaloacetate-decarboxylating) 
                EC 1.1.1.39                      malate dehydrogenase (decarboxylating) 
                EC 1.1.1.40                      malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) 
                EC 1.1.1.41                      isocitrate dehydrogenase (NAD+) 
                EC 1.1.1.42                      isocitrate dehydrogenase (NADP+) 
                EC 1.1.1.43                      phosphogluconate 2-dehydrogenase 
                EC 1.1.1.44                      phosphogluconate dehydrogenase (NADP+-dependent, decarboxylating) 
                EC 1.1.1.45                      L-gulonate 3-dehydrogenase 
                EC 1.1.1.46                      L-arabinose 1-dehydrogenase 
                EC 1.1.1.47                      glucose 1-dehydrogenase [NAD(P)+] 
                EC 1.1.1.48                      D-galactose 1-dehydrogenase 
                EC 1.1.1.49                      glucose-6-phosphate dehydrogenase (NADP+) 
                EC 1.1.1.50                      3α-hydroxysteroid 3-dehydrogenase (Si-specific) 
                EC 1.1.1.51                      3(or 17)β-hydroxysteroid dehydrogenase 
                EC 1.1.1.52                      3α-hydroxycholanate dehydrogenase (NAD+) 
                EC 1.1.1.53                      3α(or 20β)-hydroxysteroid dehydrogenase 
                EC 1.1.1.54                      allyl-alcohol dehydrogenase 
                EC 1.1.1.55                      lactaldehyde reductase (NADPH) 
                EC 1.1.1.56                      ribitol 2-dehydrogenase 
                EC 1.1.1.57                      fructuronate reductase 
                EC 1.1.1.58                      tagaturonate reductase 
                EC 1.1.1.59                      3-hydroxypropionate dehydrogenase 
                EC 1.1.1.60                      2-hydroxy-3-oxopropionate reductase 
                EC 1.1.1.61                      4-hydroxybutyrate dehydrogenase 
                EC 1.1.1.62                      17β-estradiol 17-dehydrogenase 
                EC 1.1.1.63                      testosterone 17β-dehydrogenase. Now EC 1.1.1.239, 3α(17β)-hydroxysteroid dehydrogenase (NAD+) 
                EC 1.1.1.64                      testosterone 17β-dehydrogenase (NADP+) 
                EC 1.1.1.65                      pyridoxine 4-dehydrogenase 
                EC 1.1.1.66                      ω-hydroxydecanoate dehydrogenase 
                EC 1.1.1.67                      mannitol 2-dehydrogenase 
                EC 1.1.1.68                      5,10-methylenetetrahydrofolate reductase. Now EC 1.5.1.20, methylenetetrahydrofolate reductase [NAD(P)H] 
                EC 1.1.1.69                      gluconate 5-dehydrogenase 
                EC 1.1.1.70                       D-glucuronolactone dehydrogenase. Now included with EC 1.2.1.3 aldehyde dehydrogenase (NAD+) 
                EC 1.1.1.71                      alcohol dehydrogenase [NAD(P)+] 
                EC 1.1.1.72                      glycerol dehydrogenase (NADP+) 
                EC 1.1.1.73                      octanol dehydrogenase 
                EC 1.1.1.74                       D-aminopropanol dehydrogenase (reaction due to EC 1.1.1.4 (R,R)-butanediol dehydrogenase) 
                EC 1.1.1.75                      (R)-aminopropanol dehydrogenase 
                EC 1.1.1.76                      (S,S)-butanediol dehydrogenase 
                EC 1.1.1.77                      lactaldehyde reductase 
                EC 1.1.1.78                      methylglyoxal reductase (NADH) 
                EC 1.1.1.79                      glyoxylate reductase (NADP+) 
                EC 1.1.1.80                      isopropanol dehydrogenase (NADP+) 
                EC 1.1.1.81                      hydroxypyruvate reductase 
                EC 1.1.1.82                      malate dehydrogenase (NADP+) 
                EC 1.1.1.83                      D-malate dehydrogenase (decarboxylating) 
                EC 1.1.1.84                      dimethylmalate dehydrogenase 
                EC 1.1.1.85                      3-isopropylmalate dehydrogenase 
                EC 1.1.1.86                      ketol-acid reductoisomerase (NADP+) 
                EC 1.1.1.87                      homoisocitrate dehydrogenase 
                EC 1.1.1.88                      hydroxymethylglutaryl-CoA reductase 
                EC 1.1.1.89                       dihydroxyisovalerate dehydrogenase (isomerizing). Now included with EC 1.1.1.86 ketol-acid reductoisomerase 
                EC 1.1.1.90                      aryl-alcohol dehydrogenase 
                EC 1.1.1.91                      aryl-alcohol dehydrogenase (NADP+) 
                EC 1.1.1.92                      oxaloglycolate reductase (decarboxylating) 
                EC 1.1.1.93                      tartrate dehydrogenase 
                EC 1.1.1.94                      glycerol-3-phosphate dehydrogenase [NAD(P)+] 
                EC 1.1.1.95                      phosphoglycerate dehydrogenase 
                EC 1.1.1.96                      diiodophenylpyruvate reductase 
                EC 1.1.1.97                      3-hydroxybenzyl-alcohol dehydrogenase 
                EC 1.1.1.98                      (R)-2-hydroxy-fatty-acid dehydrogenase 
                EC 1.1.1.99                      (S)-2-hydroxy-fatty-acid dehydrogenase 
                EC 1.1.1.100                      3-oxoacyl-[acyl-carrier-protein] reductase 
                EC 1.1.1.101                      acylglycerone-phosphate reductase 
                EC 1.1.1.102                      3-dehydrosphinganine reductase 
                EC 1.1.1.103                      L-threonine 3-dehydrogenase 
                EC 1.1.1.104                      4-oxoproline reductase 
                EC 1.1.1.105                      all-trans-retinol dehydrogenase (NAD+) 
                EC 1.1.1.106                      pantoate 4-dehydrogenase 
                EC 1.1.1.107                      pyridoxal 4-dehydrogenase 
                EC 1.1.1.108                      carnitine 3-dehydrogenase 
                EC 1.1.1.109                      2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase. Now EC 1.3.1.28, 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase 
                EC 1.1.1.110                      indolelactate dehydrogenase 
                EC 1.1.1.111                      3-(imidazol-5-yl)lactate dehydrogenase 
                EC 1.1.1.112                      indanol dehydrogenase 
                EC 1.1.1.113                      L-xylose 1-dehydrogenase 
                EC 1.1.1.114                      apiose 1-reductase 
                EC 1.1.1.115                      ribose 1-dehydrogenase (NADP+) 
                EC 1.1.1.116                      D-arabinose 1-dehydrogenase (NAD+) 
                EC 1.1.1.117                      D-arabinose 1-dehydrogenase [NAD(P)+] 
                EC 1.1.1.118                      glucose 1-dehydrogenase (NAD+) 
                EC 1.1.1.119                      glucose 1-dehydrogenase (NADP+) 
                EC 1.1.1.120                      galactose 1-dehydrogenase (NADP+) 
                EC 1.1.1.121                      aldose 1-dehydrogenase (NAD+) 
                EC 1.1.1.122                      D-threo-aldose 1-dehydrogenase 
                EC 1.1.1.123                      sorbose 5-dehydrogenase (NADP+) 
                EC 1.1.1.124                      fructose 5-dehydrogenase (NADP+) 
                EC 1.1.1.125                      2-deoxy-D-gluconate 3-dehydrogenase 
                EC 1.1.1.126                      2-dehydro-3-deoxy-D-gluconate 6-dehydrogenase 
                EC 1.1.1.127                      2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase 
                EC 1.1.1.128                      L-idonate 2-dehydrogenase. The reaction described is covered by EC 1.1.1.264. 
                EC 1.1.1.129                      L-threonate 3-dehydrogenase 
                EC 1.1.1.130                      3-dehydro-L-gulonate 2-dehydrogenase 
                EC 1.1.1.131                      mannuronate reductase 
                EC 1.1.1.132                      GDP-mannose 6-dehydrogenase 
                EC 1.1.1.133                      dTDP-4-dehydrorhamnose reductase 
                EC 1.1.1.134                      dTDP-6-deoxy-L-talose 4-dehydrogenase (NADP+) 
                EC 1.1.1.135                      GDP-6-deoxy-D-talose 4-dehydrogenase 
                EC 1.1.1.136                      UDP-N-acetylglucosamine 6-dehydrogenase 
                EC 1.1.1.137                      ribitol-5-phosphate 2-dehydrogenase 
                EC 1.1.1.138                      mannitol 2-dehydrogenase (NADP+) 
                EC 1.1.1.139                      polyol dehydrogenase (NADP+). Now included with EC 1.1.1.21 aldehyde reductase 
                EC 1.1.1.140                      sorbitol-6-phosphate 2-dehydrogenase 
                EC 1.1.1.141                      15-hydroxyprostaglandin dehydrogenase (NAD+) 
                EC 1.1.1.142                      D-pinitol dehydrogenase 
                EC 1.1.1.143                      sequoyitol dehydrogenase 
                EC 1.1.1.144                      perillyl-alcohol dehydrogenase 
                EC 1.1.1.145                      3β-hydroxy-Δ5-steroid dehydrogenase 
                EC 1.1.1.146                      11β-hydroxysteroid dehydrogenase 
                EC 1.1.1.147                      16α-hydroxysteroid dehydrogenase 
                EC 1.1.1.148                      estradiol 17α-dehydrogenase 
                EC 1.1.1.149                      20α-hydroxysteroid dehydrogenase 
                EC 1.1.1.150                      21-hydroxysteroid dehydrogenase (NAD+) 
                EC 1.1.1.151                      21-hydroxysteroid dehydrogenase (NADP+) 
                EC 1.1.1.152                      3α-hydroxy-5β-androstane-17-one 3α-dehydrogenase 
                EC 1.1.1.153                      sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming) 
                EC 1.1.1.154                      ureidoglycolate dehydrogenase 
                EC 1.1.1.155                      homoisocitrate dehydrogenase. The enzyme is identical to EC 1.1.1.87, homoisocitrate dehydrogenase 
                EC 1.1.1.156                      glycerol 2-dehydrogenase (NADP+) 
                EC 1.1.1.157                      3-hydroxybutyryl-CoA dehydrogenase 
                EC 1.1.1.158                      UDP-N-acetylmuramate dehydrogenase. Now EC 1.3.1.98, UDP-N-acetylmuramate dehydrogenase 
                EC 1.1.1.159                      7α-hydroxysteroid dehydrogenase 
                EC 1.1.1.160                      dihydrobunolol dehydrogenase 
                EC 1.1.1.161                      cholestanetetraol 26-dehydrogenase. The activity is part of EC 1.14.13.15, cholestanetriol 26-monooxygenase  
                EC 1.1.1.162                      erythrulose reductase 
                EC 1.1.1.163                      cyclopentanol dehydrogenase 
                EC 1.1.1.164                      hexadecanol dehydrogenase 
                EC 1.1.1.165                      2-alkyn-1-ol dehydrogenase 
                EC 1.1.1.166                      hydroxycyclohexanecarboxylate dehydrogenase 
                EC 1.1.1.167                      hydroxymalonate dehydrogenase 
                EC 1.1.1.168                      2-dehydropantolactone reductase (Re-specific) 
                EC 1.1.1.169                      2-dehydropantoate 2-reductase 
                EC 1.1.1.170                      3β-hydroxysteroid-4α-carboxylate 3-dehydrogenase (decarboxylating) 
                EC 1.1.1.171                      methylenetetrahydrofolate reductase (NADPH). Now EC 1.5.1.20, methylenetetrahydrofolate reductase [NAD(P)H] 
                EC 1.1.1.172                      2-oxoadipate reductase 
                EC 1.1.1.173                      L-rhamnose 1-dehydrogenase 
                EC 1.1.1.174                      cyclohexane-1,2-diol dehydrogenase 
                EC 1.1.1.175                      D-xylose 1-dehydrogenase 
                EC 1.1.1.176                      12α-hydroxysteroid dehydrogenase 
                EC 1.1.1.177                      glycerol-3-phosphate 1-dehydrogenase (NADP+) 
                EC 1.1.1.178                      3-hydroxy-2-methylbutyryl-CoA dehydrogenase 
                EC 1.1.1.179                      D-xylose 1-dehydrogenase (NADP+) 
                EC 1.1.1.180                       mannonate dehydrogenase (NAD(P)+). Now included with EC 1.1.1.131 mannuronate reductase 
                EC 1.1.1.181                      cholest-5-ene-3β,7α-diol 3β-dehydrogenase 
                EC 1.1.1.182                       fenchol dehydrogenase. Now included with EC 1.1.1.198 (+)-borneol dehydrogenase, EC 1.1.1.227 (-)-borneol dehydrogenase and EC 1.1.1.228 (+)-sabinol dehydrogenase 
                EC 1.1.1.183                      geraniol dehydrogenase (NADP+) 
                EC 1.1.1.184                      carbonyl reductase (NADPH) 
                EC 1.1.1.185                      L-glycol dehydrogenase 
                EC 1.1.1.186                      dTDP-galactose 6-dehydrogenase 
                EC 1.1.1.187                      GDP-4-dehydro-D-rhamnose reductase 
                EC 1.1.1.188                      prostaglandin-F synthase 
                EC 1.1.1.189                      prostaglandin-E2 9-reductase 
                EC 1.1.1.190                      indole-3-acetaldehyde reductase (NADH) 
                EC 1.1.1.191                      indole-3-acetaldehyde reductase (NADPH) 
                EC 1.1.1.192                      long-chain-alcohol dehydrogenase 
                EC 1.1.1.193                      5-amino-6-(5-phosphoribosylamino)uracil reductase 
                EC 1.1.1.194                      coniferyl-alcohol dehydrogenase 
                EC 1.1.1.195                      cinnamyl-alcohol dehydrogenase 
                EC 1.1.1.196                      15-hydroxyprostaglandin-D dehydrogenase (NADP+) 
                EC 1.1.1.197                      15-hydroxyprostaglandin dehydrogenase (NADP+) 
                EC 1.1.1.198                      (+)-borneol dehydrogenase 
                EC 1.1.1.199                      (S)-usnate reductase 
                EC 1.1.1.200                      aldose-6-phosphate reductase (NADPH) 
                EC 1.1.1.201                      7β-hydroxysteroid dehydrogenase (NADP+) 
                EC 1.1.1.202                      1,3-propanediol dehydrogenase 
                EC 1.1.1.203                      uronate dehydrogenase 
                EC 1.1.1.204                      xanthine dehydrogenase. Now EC 1.17.1.4, xanthine dehydrogenase. The enzyme was incorrectly classified as acting on a CH-OH group 
                EC 1.1.1.205                      IMP dehydrogenase 
                EC 1.1.1.206                      tropinone reductase I 
                EC 1.1.1.207                      (-)-menthol dehydrogenase 
                EC 1.1.1.208                      (+)-neomenthol dehydrogenase 
                EC 1.1.1.209                      3(or 17)α-hydroxysteroid dehydrogenase 
                EC 1.1.1.210                      3β(or 20α)-hydroxysteroid dehydrogenase 
                EC 1.1.1.211                      long-chain-3-hydroxyacyl-CoA dehydrogenase 
                EC 1.1.1.212                      3-oxoacyl-[acyl-carrier-protein] reductase (NADH) 
                EC 1.1.1.213                      3α-hydroxysteroid 3-dehydrogenase (Re-specific) 
                EC 1.1.1.214                      2-dehydropantolactone reductase (Si-specific) 
                EC 1.1.1.215                      gluconate 2-dehydrogenase 
                EC 1.1.1.216                      farnesol dehydrogenase (NADP+) 
                EC 1.1.1.217                      benzyl-2-methyl-hydroxybutyrate dehydrogenase 
                EC 1.1.1.218                      morphine 6-dehydrogenase 
                EC 1.1.1.219                      dihydroflavonol 4-reductase 
                EC 1.1.1.220                      6-pyruvoyltetrahydropterin 2′-reductase 
                EC 1.1.1.221                      vomifoliol dehydrogenase 
                EC 1.1.1.222                      (R)-4-hydroxyphenyllactate dehydrogenase 
                EC 1.1.1.223                      isopiperitenol dehydrogenase 
                EC 1.1.1.224                      mannose-6-phosphate 6-reductase 
                EC 1.1.1.225                      chlordecone reductase 
                EC 1.1.1.226                      4-hydroxycyclohexanecarboxylate dehydrogenase 
                EC 1.1.1.227                      (-)-borneol dehydrogenase 
                EC 1.1.1.228                      (+)-sabinol dehydrogenase 
                EC 1.1.1.229                      diethyl 2-methyl-3-oxosuccinate reductase 
                EC 1.1.1.230                      3α-hydroxyglycyrrhetinate dehydrogenase 
                EC 1.1.1.231                      15-hydroxyprostaglandin-I dehydrogenase (NADP+) 
                EC 1.1.1.232                      15-hydroxyicosatetraenoate dehydrogenase 
                EC 1.1.1.233                      N-acylmannosamine 1-dehydrogenase 
                EC 1.1.1.234                      flavanone 4-reductase 
                EC 1.1.1.235                      8-oxocoformycin reductase 
                EC 1.1.1.236                      tropinone reductase II 
                EC 1.1.1.237                      hydroxyphenylpyruvate reductase 
                EC 1.1.1.238                      12β-hydroxysteroid dehydrogenase 
                EC 1.1.1.239                      3α(17β)-hydroxysteroid dehydrogenase (NAD+) 
                EC 1.1.1.240                      N-acetylhexosamine 1-dehydrogenase 
                EC 1.1.1.241                      6-endo-hydroxycineole dehydrogenase 
                EC 1.1.1.242                      zeatin reductase. Now EC 1.3.1.69, zeatin reductase 
                EC 1.1.1.243                      carveol dehydrogenase 
                EC 1.1.1.244                      methanol dehydrogenase 
                EC 1.1.1.245                      cyclohexanol dehydrogenase 
                EC 1.1.1.246                      pterocarpin synthase. This activity is now known to be catalysed by two enzymes, vestitone reductase (EC 1.1.1.348) and medicarpin synthase (EC 4.2.1.139). 
                EC 1.1.1.247                      codeinone reductase (NADPH) 
                EC 1.1.1.248                      salutaridine reductase (NADPH) 
                EC 1.1.1.249                      Provisional entry deleted. Revised and reinstated as EC 2.5.1.46 deoxyhypusine synthase 
                EC 1.1.1.250                      D-arabinitol 2-dehydrogenase 
                EC 1.1.1.251                      galactitol-1-phosphate 5-dehydrogenase 
                EC 1.1.1.252                      tetrahydroxynaphthalene reductase 
                EC 1.1.1.253                      pteridine reductase. Now EC 1.5.1.33, pteridine reductase 
                EC 1.1.1.254                      (S)-carnitine 3-dehydrogenase 
                EC 1.1.1.255                      mannitol dehydrogenase 
                EC 1.1.1.256                      fluoren-9-ol dehydrogenase 
                EC 1.1.1.257                      4-(hydroxymethyl)benzenesulfonate dehydrogenase 
                EC 1.1.1.258                      6-hydroxyhexanoate dehydrogenase 
                EC 1.1.1.259                      3-hydroxypimeloyl-CoA dehydrogenase 
                EC 1.1.1.260                      sulcatone reductase 
                EC 1.1.1.261                      sn-glycerol-1-phosphate dehydrogenase 
                EC 1.1.1.262                      4-hydroxythreonine-4-phosphate dehydrogenase 
                EC 1.1.1.263                      1,5-anhydro-D-fructose reductase 
                EC 1.1.1.264                      L-idonate 5-dehydrogenase 
                EC 1.1.1.265                      3-methylbutanal reductase 
                EC 1.1.1.266                      dTDP-4-dehydro-6-deoxyglucose reductase 
                EC 1.1.1.267                      1-deoxy-D-xylulose-5-phosphate reductoisomerase 
                EC 1.1.1.268                      2-(R)-hydroxypropyl-CoM dehydrogenase 
                EC 1.1.1.269                      2-(S)-hydroxypropyl-CoM dehydrogenase 
                EC 1.1.1.270                      3β-hydroxysteroid 3-dehydrogenase 
                EC 1.1.1.271                      GDP-L-fucose synthase 
                EC 1.1.1.272                      D-2-hydroxyacid dehydrogenase (NADP+) 
                EC 1.1.1.273                      vellosimine dehydrogenase 
                EC 1.1.1.274                      2,5-didehydrogluconate reductase (2-dehydro-D-gluconate-forming) 
                EC 1.1.1.275                      (+)-trans-carveol dehydrogenase 
                EC 1.1.1.276                      serine 3-dehydrogenase (NADP+) 
                EC 1.1.1.277                      3β-hydroxy-5β-steroid dehydrogenase 
                EC 1.1.1.278                      3β-hydroxy-5α-steroid dehydrogenase 
                EC 1.1.1.279                      (R)-3-hydroxyacid-ester dehydrogenase 
                EC 1.1.1.280                      (S)-3-hydroxyacid-ester dehydrogenase 
                EC 1.1.1.281                      GDP-4-dehydro-6-deoxy-D-mannose reductase 
                EC 1.1.1.282                      quinate/shikimate dehydrogenase 
                EC 1.1.1.283                      methylglyoxal reductase (NADPH) 
                EC 1.1.1.284                      S-(hydroxymethyl)glutathione dehydrogenase 
                EC 1.1.1.285                      3′′-deamino-3′′-oxonicotianamine reductase 
                EC 1.1.1.286                      isocitrate—homoisocitrate dehydrogenase 
                EC 1.1.1.287                      D-arabinitol dehydrogenase (NADP+) 
                EC 1.1.1.288                      xanthoxin dehydrogenase 
                EC 1.1.1.289                      sorbose reductase 
                EC 1.1.1.290                      4-phosphoerythronate dehydrogenase 
                EC 1.1.1.291                      2-hydroxymethylglutarate dehydrogenase 
                EC 1.1.1.292                      1,5-anhydro-D-fructose reductase (1,5-anhydro-D-mannitol-forming) 
                EC 1.1.1.293                      tropinone reductase I. This enzyme was already in the Enzyme List as EC 1.1.1.206, tropine dehydrogenase so EC 1.1.1.293 has been withdrawn at the public-review stage 
                EC 1.1.1.294                      chlorophyll(ide) b reductase 
                EC 1.1.1.295                      momilactone-A synthase 
                EC 1.1.1.296                      dihydrocarveol dehydrogenase 
                EC 1.1.1.297                      limonene-1,2-diol dehydrogenase 
                EC 1.1.1.298                      3-hydroxypropionate dehydrogenase (NADP+) 
                EC 1.1.1.299                      malate dehydrogenase [NAD(P)+] 
                EC 1.1.1.300                      NADP-retinol dehydrogenase 
                EC 1.1.1.301                      D-arabitol-phosphate dehydrogenase 
                EC 1.1.1.302                      2,5-diamino-6-(ribosylamino)-4(3H)-pyrimidinone 5′-phosphate reductase 
                EC 1.1.1.303                      diacetyl reductase [(R)-acetoin forming] 
                EC 1.1.1.304                      diacetyl reductase [(S)-acetoin forming] 
                EC 1.1.1.305                      UDP-glucuronic acid dehydrogenase (UDP-4-keto-hexauronic acid decarboxylating) 
                EC 1.1.1.306                      S-(hydroxymethyl)mycothiol dehydrogenase 
                EC 1.1.1.307                      D-xylose reductase 
                EC 1.1.1.308                      sulfopropanediol 3-dehydrogenase 
                EC 1.1.1.309                      phosphonoacetaldehyde reductase (NADH) 
                EC 1.1.1.310                      (S)-sulfolactate dehydrogenase 
                EC 1.1.1.311                      (S)-1-phenylethanol dehydrogenase 
                EC 1.1.1.312                      2-hydroxy-4-carboxymuconate semialdehyde hemiacetal dehydrogenase 
                EC 1.1.1.313                      sulfoacetaldehyde reductase 
                EC 1.1.1.314                      germacrene A alcohol dehydrogenase 
                EC 1.1.1.315                      11-cis-retinol dehydrogenase 
                EC 1.1.1.316                      L-galactose 1-dehydrogenase 
                EC 1.1.1.317                      perakine reductase 
                EC 1.1.1.318                      eugenol synthase 
                EC 1.1.1.319                      isoeugenol synthase 
                EC 1.1.1.320                      benzil reductase [(S)-benzoin forming] 
                EC 1.1.1.321                      benzil reductase [(R)-benzoin forming] 
                EC 1.1.1.322                      (–)-endo-fenchol dehydrogenase 
                EC 1.1.1.323                      (+)-thujan-3-ol dehydrogenase 
                EC 1.1.1.324                      8-hydroxygeraniol dehydrogenase 
                EC 1.1.1.325                      sepiapterin reductase (L-threo-7,8-dihydrobiopterin forming) 
                EC 1.1.1.326                      zerumbone synthase 
                EC 1.1.1.327                      5-exo-hydroxycamphor dehydrogenase 
                EC 1.1.1.328                      nicotine blue oxidoreductase 
                EC 1.1.1.329                      2-deoxy-scyllo-inosamine dehydrogenase 
                EC 1.1.1.330                      very-long-chain 3-oxoacyl-CoA reductase 
                EC 1.1.1.331                      secoisolariciresinol dehydrogenase 
                EC 1.1.1.332                      chanoclavine-I dehydrogenase 
                EC 1.1.1.333                      decaprenylphospho-β-D-erythro-pentofuranosid-2-ulose 2-reductase 
                EC 1.1.1.334                      methylecgonone reductase 
                EC 1.1.1.335                      UDP-N-acetyl-2-amino-2-deoxyglucuronate dehydrogenase 
                EC 1.1.1.336                      UDP-N-acetyl-D-mannosamine dehydrogenase 
                EC 1.1.1.337                      L-2-hydroxycarboxylate dehydrogenase (NAD+) 
                EC 1.1.1.338                      (2R)-3-sulfolactate dehydrogenase (NADP+) 
                EC 1.1.1.339                      dTDP-6-deoxy-L-talose 4-dehydrogenase (NAD+) 
                EC 1.1.1.340                      1-deoxy-11β-hydroxypentalenate dehydrogenase 
                EC 1.1.1.341                      CDP-abequose synthase 
                EC 1.1.1.342                      CDP-paratose synthase 
                EC 1.1.1.343                      phosphogluconate dehydrogenase (NAD+-dependent, decarboxylating) 
                EC 1.1.1.344                      dTDP-6-deoxy-L-talose 4-dehydrogenase [NAD(P)+] 
                EC 1.1.1.345                      D-2-hydroxyacid dehydrogenase (NAD+) 
                EC 1.1.1.346                      2,5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming) 
                EC 1.1.1.347                      geraniol dehydrogenase (NAD+) 
                EC 1.1.1.348                      vestitone reductase 
                EC 1.1.1.349                      norsolorinic acid ketoreductase 
                EC 1.1.1.350                      ureidoglycolate dehydrogenase (NAD+) 
                EC 1.1.1.351                      phosphogluconate dehydrogenase [NAD(P)+-dependent, decarboxylating] 
                EC 1.1.1.352                      5′-hydroxyaverantin dehydrogenase 
                EC 1.1.1.353                      versiconal hemiacetal acetate reductase 
                EC 1.1.1.354                      farnesol dehydrogenase (NAD+) 
                EC 1.1.1.355                      2′-dehydrokanamycin reductase 
                EC 1.1.1.356                      GDP-L-colitose synthase 
                EC 1.1.1.357                      3α-hydroxysteroid 3-dehydrogenase 
                EC 1.1.1.358                      2-dehydropantolactone reductase 
                EC 1.1.1.359                      aldose 1-dehydrogenase [NAD(P)+] 
                EC 1.1.1.360                      glucose/galactose 1-dehydrogenase 
                EC 1.1.1.361                      glucose-6-phosphate 3-dehydrogenase 
                EC 1.1.1.362                      aklaviketone reductase 
                EC 1.1.1.363                      glucose-6-phosphate dehydrogenase [NAD(P)+] 
                EC 1.1.1.364                      dTDP-4-dehydro-6-deoxy-α-D-gulose 4-ketoreductase 
                EC 1.1.1.365                      D-galacturonate reductase 
                EC 1.1.1.366                      L-idonate 5-dehydrogenase (NAD+) 
                EC 1.1.1.367                      UDP-2-acetamido-2,6-β-L-arabino-hexul-4-ose reductase 
                EC 1.1.1.368                      6-hydroxycyclohex-1-ene-1-carbonyl-CoA dehydrogenase 
                EC 1.1.1.369                      D-chiro-inositol 1-dehydrogenase 
                EC 1.1.1.370                      scyllo-inositol 2-dehydrogenase (NAD+) 
                EC 1.1.1.371                      scyllo-inositol 2-dehydrogenase (NADP+) 
                EC 1.1.1.372                      D/L-glyceraldehyde reductase 
                EC 1.1.1.373                      sulfolactaldehyde 3-reductase 
                EC 1.1.1.374                      UDP-N-acetylglucosamine 3-dehydrogenase 
                EC 1.1.1.375                      L-2-hydroxycarboxylate dehydrogenase [NAD(P)+] 
                EC 1.1.1.376                      L-arabinose 1-dehydrogenase [NAD(P)+] 
                EC 1.1.1.377                      L-rhamnose 1-dehydrogenase (NADP+) 
                EC 1.1.1.378                      L-rhamnose 1-dehydrogenase [NAD(P)+] 
                EC 1.1.1.379                      (R)-mandelate dehydrogenase 
                EC 1.1.1.380                      L-gulonate 5-dehydrogenase 
                EC 1.1.1.381                      3-hydroxy acid dehydrogenase 
                EC 1.1.1.382                      ketol-acid reductoisomerase (NAD+) 
                EC 1.1.1.383                      ketol-acid reductoisomerase [NAD(P)+] 
                EC 1.1.1.384                      dTDP-3,4-didehydro-2,6-dideoxy-α-D-glucose 3-reductase 
                EC 1.1.1.385                      dihydroanticapsin dehydrogenase 
                EC 1.1.1.386                      ipsdienol dehydrogenase 
                EC 1.1.1.387                      L-serine 3-dehydrogenase (NAD+) 
                EC 1.1.1.388                      glucose-6-phosphate dehydrogenase (NAD+) 
                EC 1.1.1.389                      2-dehydro-3-deoxy-L-galactonate 5-dehydrogenase 
                EC 1.1.1.390                      sulfoquinovose 1-dehydrogenase 
                EC 1.1.1.391                      3β-hydroxycholanate 3-dehydrogenase (NAD+) 
                EC 1.1.1.392                      3α-hydroxycholanate dehydrogenase (NADP+) 
                EC 1.1.1.393                      3β-hydroxycholanate 3-dehydrogenase (NADP+) 
                EC 1.1.1.394                      aurachin B dehydrogenase 
                EC 1.1.1.395                      3α-hydroxy bile acid-CoA-ester 3-dehydrogenase 
                EC 1.1.1.396                      bacteriochlorophyllide a dehydrogenase 
                EC 1.1.1.397                      β-methylindole-3-pyruvate reductase 
                EC 1.1.1.398                      2-glutathionyl-2-methylbut-3-en-1-ol dehydrogenase 
                EC 1.1.1.399                      2-oxoglutarate reductase 
                EC 1.1.1.400                      2-methyl-1,2-propanediol dehydrogenase 
                EC 1.1.1.401                      2-dehydro-3-deoxy-L-rhamnonate dehydrogenase (NAD+) 
                EC 1.1.1.402                      D-erythritol 1-phosphate dehydrogenase 
                EC 1.1.1.403                      D-threitol dehydrogenase (NAD+) 
                EC 1.1.1.404                      tetrachlorobenzoquinone reductase 
                EC 1.1.1.405                      ribitol-5-phosphate 2-dehydrogenase (NADP+) 
                EC 1.1.1.406                      galactitol 2-dehydrogenase (L-tagatose-forming) 
                EC 1.1.1.407                      D-altritol 5-dehydrogenase 
        EC 1.1.2       []    With a cytochrome as acceptor 
                EC 1.1.2.1                      glycerolphosphate dehydrogenase. As the acceptor is now known, the enzyme has been transferred to EC 1.1.5.3, glycerol-3-phosphate dehydrogenase. 
                EC 1.1.2.2                      mannitol dehydrogenase (cytochrome) 
                EC 1.1.2.3                      L-lactate dehydrogenase (cytochrome) 
                EC 1.1.2.4                      D-lactate dehydrogenase (cytochrome) 
                EC 1.1.2.5                      D-lactate dehydrogenase (cytochrome c-553) 
                EC 1.1.2.6                      polyvinyl alcohol dehydrogenase (cytochrome) 
                EC 1.1.2.7                      methanol dehydrogenase (cytochrome c) 
                EC 1.1.2.8                      alcohol dehydrogenase (cytochrome c) 
                EC 1.1.2.9                      1-butanol dehydrogenase (cytochrome c) 
        EC 1.1.3       []    With oxygen as acceptor 
                EC 1.1.3.1                       glycolate oxidase. Now included with EC 1.1.3.15 (S)-2-hydroxy-acid oxidase 
                EC 1.1.3.2                      lactate oxidase. Now EC 1.13.12.4, lactate 2-monooxygenase 
                EC 1.1.3.3                      malate oxidase. Now classified as EC 1.1.5.4, malate dehydrogenase (quinone).  
                EC 1.1.3.4                      glucose oxidase 
                EC 1.1.3.5                      hexose oxidase 
                EC 1.1.3.6                      cholesterol oxidase 
                EC 1.1.3.7                      aryl-alcohol oxidase 
                EC 1.1.3.8                      L-gulonolactone oxidase 
                EC 1.1.3.9                      galactose oxidase 
                EC 1.1.3.10                      pyranose oxidase 
                EC 1.1.3.11                      L-sorbose oxidase 
                EC 1.1.3.12                      pyridoxine 4-oxidase 
                EC 1.1.3.13                      alcohol oxidase 
                EC 1.1.3.14                      catechol oxidase (dimerizing) 
                EC 1.1.3.15                      (S)-2-hydroxy-acid oxidase 
                EC 1.1.3.16                      ecdysone oxidase 
                EC 1.1.3.17                      choline oxidase 
                EC 1.1.3.18                      secondary-alcohol oxidase 
                EC 1.1.3.19                      4-hydroxymandelate oxidase (decarboxylating) 
                EC 1.1.3.20                      long-chain-alcohol oxidase 
                EC 1.1.3.21                      glycerol-3-phosphate oxidase 
                EC 1.1.3.22                      xanthine oxidase. Now EC 1.17.3.2, xanthine oxidase. The enzyme was incorrectly classified as acting on a CH-OH group 
                EC 1.1.3.23                      thiamine oxidase 
                EC 1.1.3.24                      L-galactonolactone oxidase. Now EC 1.3.3.12, L-galactonolactone oxidase. The enzyme had been incorrectly classified as acting upon a CH-OH donor rather than a CH-CH donor 
                EC 1.1.3.25                      cellobiose oxidase. Now included with EC 1.1.99.18, cellobiose dehydrogenase (acceptor) 
                EC 1.1.3.26                      columbamine oxidase. Now EC 1.21.3.2, columbamine oxidase 
                EC 1.1.3.27                      hydroxyphytanate oxidase 
                EC 1.1.3.28                      nucleoside oxidase 
                EC 1.1.3.29                      N-acylhexosamine oxidase 
                EC 1.1.3.30                      polyvinyl-alcohol oxidase 
                EC 1.1.3.31                       methanol oxidase. Cannot be distinguished from EC 1.1.3.13, alcohol oxidase 
                EC 1.1.3.32                      (S)-stylopine synthase. Now EC 1.14.21.1, (S)-stylopine synthase 
                EC 1.1.3.33                      S-cheilanthifoline synthase. Now EC 1.14.21.2, (S)-cheilanthifoline synthase 
                EC 1.1.3.34                      berbamunine synthase. Now EC 1.14.21.3, berbamunine synthase 
                EC 1.1.3.35                      salutaridine synthase. Now EC 1.14.21.4, salutaridine synthase 
                EC 1.1.3.36                      (S)-canadine synthase. Now EC 1.14.21.5, (S)-canadine synthase 
                EC 1.1.3.37                      D-arabinono-1,4-lactone oxidase 
                EC 1.1.3.38                      vanillyl-alcohol oxidase 
                EC 1.1.3.39                      nucleoside oxidase (H2O2-forming) 
                EC 1.1.3.40                      D-mannitol oxidase 
                EC 1.1.3.41                      alditol oxidase 
                EC 1.1.3.42                      prosolanapyrone-II oxidase 
                EC 1.1.3.43                      paromamine 6′-oxidase 
                EC 1.1.3.44                      6′′′-hydroxyneomycin C oxidase 
                EC 1.1.3.45                      aclacinomycin-N oxidase 
                EC 1.1.3.46                      4-hydroxymandelate oxidase 
                EC 1.1.3.47                      5-(hydroxymethyl)furfural oxidase 
                EC 1.1.3.48                      3-deoxy-α-D-manno-octulosonate 8-oxidase 
                EC 1.1.3.49                      (R)-mandelonitrile oxidase 
        EC 1.1.4       []    With a disulfide as acceptor 
                EC 1.1.4.1                      vitamin-K-epoxide reductase (warfarin-sensitive). Now EC 1.17.4.4, vitamin-K-epoxide reductase (warfarin-sensitive) 
                EC 1.1.4.2                      vitamin-K-epoxide reductase (warfarin-insensitive). Now EC 1.17.4.5, vitamin-K-epoxide reductase (warfarin-insensitive) 
        EC 1.1.5       []    With a quinone or similar compound as acceptor 
                EC 1.1.5.1                       cellobiose dehydrogenase (quinone). Now known to be proteolytic product of EC 1.1.99.18, cellobiose dehydrogenase (acceptor) 
                EC 1.1.5.2                      glucose 1-dehydrogenase (PQQ, quinone) 
                EC 1.1.5.3                      glycerol-3-phosphate dehydrogenase 
                EC 1.1.5.4                      malate dehydrogenase (quinone) 
                EC 1.1.5.5                      alcohol dehydrogenase (quinone) 
                EC 1.1.5.6                      formate dehydrogenase-N 
                EC 1.1.5.7                      cyclic alcohol dehydrogenase (quinone) 
                EC 1.1.5.8                      quinate dehydrogenase (quinone) 
                EC 1.1.5.9                      glucose 1-dehydrogenase (FAD, quinone) 
                EC 1.1.5.10                      D-2-hydroxyacid dehydrogenase (quinone) 
                EC 1.1.5.11                      1-butanol dehydrogenase (quinone) 
                EC 1.1.5.12                      D-lactate dehydrogenase (quinone) 
        EC 1.1.9       []    With a copper protein as acceptor 
                EC 1.1.9.1                      alcohol dehydrogenase (azurin) 
        EC 1.1.98       []    With other, known, physiological acceptors 
                EC 1.1.98.1                      Now EC 1.1.9.1, alcohol dehydrogenase (azurin) 
                EC 1.1.98.2                      glucose-6-phosphate dehydrogenase (coenzyme-F420) 
                EC 1.1.98.3                      decaprenylphospho-β-D-ribofuranose 2-dehydrogenase 
                EC 1.1.98.4                      F420H2:quinone oxidoreductase 
                EC 1.1.98.5                      secondary-alcohol dehydrogenase (coenzyme-F420) 
                EC 1.1.98.6                      ribonucleoside-triphosphate reductase (formate) 
        EC 1.1.99       []    With unknown physiological acceptors 
                EC 1.1.99.1                      choline dehydrogenase 
                EC 1.1.99.2                      L-2-hydroxyglutarate dehydrogenase 
                EC 1.1.99.3                      gluconate 2-dehydrogenase (acceptor) 
                EC 1.1.99.4                      dehydrogluconate dehydrogenase 
                EC 1.1.99.5                      glycerol-3-phosphate dehydrogenase. As the acceptor is now known, the enzyme has been transferred to EC 1.1.5.3, glycerol-3-phosphate dehydrogenase. 
                EC 1.1.99.6                      D-lactate dehydrogenase (acceptor) 
                EC 1.1.99.7                      lactate—malate transhydrogenase 
                EC 1.1.99.8                      alcohol dehydrogenase (acceptor). Now EC 1.1.2.7, methanol dehydrogenase (cytochrome c) and EC 1.1.2.8, alcohol dehydrogenase (cytochrome c). 
                EC 1.1.99.9                      pyridoxine 5-dehydrogenase 
                EC 1.1.99.10                      glucose dehydrogenase (acceptor). Now EC 1.1.5.9, glucose 1-dehydrogenase (FAD, quinone) 
                EC 1.1.99.11                      fructose 5-dehydrogenase 
                EC 1.1.99.12                      sorbose dehydrogenase 
                EC 1.1.99.13                      glucoside 3-dehydrogenase 
                EC 1.1.99.14                      glycolate dehydrogenase 
                EC 1.1.99.15                      5,10-methylenetetrahydrofolate reductase (FADH2). Now EC 1.5.1.20, methylenetetrahydrofolate reductase [NAD(P)H] 
                EC 1.1.99.16                      malate dehydrogenase (acceptor). As the acceptor is now known, the enzyme has been transferred to EC 1.1.5.4, malate dehydrogenase (quinone). 
                EC 1.1.99.17                      glucose dehydrogenase (pyrroloquinoline-quinone). Now EC 1.1.5.2, quinoprotein glucose dehydrogenase 
                EC 1.1.99.18                      cellobiose dehydrogenase (acceptor) 
                EC 1.1.99.19                      uracil dehydrogenase. Now EC 1.17.99.4, uracil/thymine dehydrogenase 
                EC 1.1.99.20                      alkan-1-ol dehydrogenase (acceptor) 
                EC 1.1.99.21                      D-sorbitol dehydrogenase (acceptor) 
                EC 1.1.99.22                      glycerol dehydrogenase (acceptor) 
                EC 1.1.99.23                      polyvinyl-alcohol dehydrogenase (acceptor). Now EC 1.1.2.6, polyvinyl alcohol dehydrogenase (cytochrome) 
                EC 1.1.99.24                      hydroxyacid-oxoacid transhydrogenase 
                EC 1.1.99.25                      quinate dehydrogenase (pyrroloquinoline-quinone). Now EC 1.1.5.8, quinate dehydrogenase (quinone) 
                EC 1.1.99.26                      3-hydroxycyclohexanone dehydrogenase 
                EC 1.1.99.27                      (R)-pantolactone dehydrogenase (flavin) 
                EC 1.1.99.28                      glucose-fructose oxidoreductase 
                EC 1.1.99.29                      pyranose dehydrogenase (acceptor) 
                EC 1.1.99.30                      2-oxo-acid reductase 
                EC 1.1.99.31                      (S)-mandelate dehydrogenase 
                EC 1.1.99.32                      L-sorbose 1-dehydrogenase 
                EC 1.1.99.33                      formate dehydrogenase (acceptor) 
                EC 1.1.99.34                      glucose-6-phosphate dehydrogenase (coenzyme-F420). As the acceptor is now known, the enzyme has been transferred to EC 1.1.98.2, glucose-6-phosphate dehydrogenase (coenzyme-F420) 
                EC 1.1.99.35                      soluble quinoprotein glucose dehydrogenase 
                EC 1.1.99.36                      alcohol dehydrogenase (nicotinoprotein) 
                EC 1.1.99.37                      methanol dehydrogenase (nicotinoprotein) 
                EC 1.1.99.38                      2-deoxy-scyllo-inosamine dehydrogenase (AdoMet-dependent) 
                EC 1.1.99.39                      D-2-hydroxyglutarate dehydrogenase 
                EC 1.1.99.40                      (R)-2-hydroxyglutarate—pyruvate transhydrogenase 
    EC 1.2  [+]      
        EC 1.2.1       []    With NAD+ or NADP+ as acceptor 
                EC 1.2.1.1                       glutathione-dependent formaldehyde dehydrogenase. This enzyme was classified on the basis of an incorrect reaction. It has been replaced by two enzymes, EC 1.1.1.284, S-(hydroxymethyl)glutathione dehydrogenase and EC 4.4.1.22, S-(hydroxymethyl)glutathione synthase 
                EC 1.2.1.2                      formate dehydrogenase 
                EC 1.2.1.3                      aldehyde dehydrogenase (NAD+) 
                EC 1.2.1.4                      aldehyde dehydrogenase (NADP+) 
                EC 1.2.1.5                      aldehyde dehydrogenase [NAD(P)+] 
                EC 1.2.1.6                       benzaldehyde dehydrogenase 
                EC 1.2.1.7                      benzaldehyde dehydrogenase (NADP+) 
                EC 1.2.1.8                      betaine-aldehyde dehydrogenase 
                EC 1.2.1.9                      glyceraldehyde-3-phosphate dehydrogenase (NADP+) 
                EC 1.2.1.10                      acetaldehyde dehydrogenase (acetylating) 
                EC 1.2.1.11                      aspartate-semialdehyde dehydrogenase 
                EC 1.2.1.12                      glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 
                EC 1.2.1.13                      glyceraldehyde-3-phosphate dehydrogenase (NADP+) (phosphorylating) 
                EC 1.2.1.14                      IMP dehydrogenase. Now EC 1.1.1.205, IMP dehydrogenase 
                EC 1.2.1.15                      malonate-semialdehyde dehydrogenase 
                EC 1.2.1.16                      succinate-semialdehyde dehydrogenase [NAD(P)+] 
                EC 1.2.1.17                      glyoxylate dehydrogenase (acylating) 
                EC 1.2.1.18                      malonate-semialdehyde dehydrogenase (acetylating) 
                EC 1.2.1.19                      aminobutyraldehyde dehydrogenase 
                EC 1.2.1.20                      glutarate-semialdehyde dehydrogenase 
                EC 1.2.1.21                      glycolaldehyde dehydrogenase 
                EC 1.2.1.22                      lactaldehyde dehydrogenase 
                EC 1.2.1.23                      2-oxoaldehyde dehydrogenase (NAD+) 
                EC 1.2.1.24                      succinate-semialdehyde dehydrogenase (NAD+) 
                EC 1.2.1.25                      2-oxoisovalerate dehydrogenase (acylating) 
                EC 1.2.1.26                      2,5-dioxovalerate dehydrogenase 
                EC 1.2.1.27                      methylmalonate-semialdehyde dehydrogenase (CoA-acylating) 
                EC 1.2.1.28                      benzaldehyde dehydrogenase (NAD+) 
                EC 1.2.1.29                      aryl-aldehyde dehydrogenase 
                EC 1.2.1.30                      aryl-aldehyde dehydrogenase (NADP+) 
                EC 1.2.1.31                      L-aminoadipate-semialdehyde dehydrogenase 
                EC 1.2.1.32                      aminomuconate-semialdehyde dehydrogenase 
                EC 1.2.1.33                      (R)-dehydropantoate dehydrogenase 
                EC 1.2.1.34                      D-mannonate dehydrogenase (NAD(P)+). Now EC 1.1.1.131, mannuronate reductase 
                EC 1.2.1.35                      uronate dehydrogenase. Now EC 1.1.1.203, uronate dehydrogenase 
                EC 1.2.1.36                      retinal dehydrogenase 
                EC 1.2.1.37                      xanthine dehydrogenase. Now EC 1.17.1.4, xanthine dehydrogenase 
                EC 1.2.1.38                      N-acetyl-γ-glutamyl-phosphate reductase 
                EC 1.2.1.39                      phenylacetaldehyde dehydrogenase 
                EC 1.2.1.40                      3α,7α,12α-trihydroxycholestan-26-al 26-oxidoreductase. The activity is part of EC 1.14.13.15, cholestanetriol 26-monooxygenase 
                EC 1.2.1.41                      glutamate-5-semialdehyde dehydrogenase 
                EC 1.2.1.42                      hexadecanal dehydrogenase (acylating) 
                EC 1.2.1.43                      formate dehydrogenase (NADP+) 
                EC 1.2.1.44                      cinnamoyl-CoA reductase 
                EC 1.2.1.45                      4-carboxy-2-hydroxymuconate-6-semialdehyde dehydrogenase. Now EC 1.1.1.312, 2-hydroxy-4-carboxymuconate semialdehyde hemiacetal dehydrogenase. 
                EC 1.2.1.46                      formaldehyde dehydrogenase 
                EC 1.2.1.47                      4-trimethylammoniobutyraldehyde dehydrogenase 
                EC 1.2.1.48                      long-chain-aldehyde dehydrogenase 
                EC 1.2.1.49                      2-oxoaldehyde dehydrogenase (NADP+) 
                EC 1.2.1.50                      long-chain acyl-protein thioester reductase 
                EC 1.2.1.51                      pyruvate dehydrogenase (NADP+) 
                EC 1.2.1.52                      oxoglutarate dehydrogenase (NADP+) 
                EC 1.2.1.53                      4-hydroxyphenylacetaldehyde dehydrogenase 
                EC 1.2.1.54                      γ-guanidinobutyraldehyde dehydrogenase 
                EC 1.2.1.55                      (R)-3-hydroxyacid ester dehydrogenase. Now EC 1.1.1.279, (R)-3-hydroxyacid-ester dehydrogenase 
                EC 1.2.1.56                      (S)-3-hydroxyacid ester dehydrogenase. Now EC 1.1.1.280, (S)-3-hydroxyacid-ester dehydrogenase 
                EC 1.2.1.57                      butanal dehydrogenase 
                EC 1.2.1.58                      phenylglyoxylate dehydrogenase (acylating) 
                EC 1.2.1.59                      glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) 
                EC 1.2.1.60                      5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase 
                EC 1.2.1.61                      4-hydroxymuconic-semialdehyde dehydrogenase 
                EC 1.2.1.62                      4-formylbenzenesulfonate dehydrogenase 
                EC 1.2.1.63                      6-oxohexanoate dehydrogenase 
                EC 1.2.1.64                      4-hydroxybenzaldehyde dehydrogenase (NAD+) 
                EC 1.2.1.65                      salicylaldehyde dehydrogenase 
                EC 1.2.1.66                      mycothiol-dependent formaldehyde dehydrogenase. Now EC 1.1.1.306, S-(hydroxymethyl)mycothiol dehydrogenase 
                EC 1.2.1.67                      vanillin dehydrogenase 
                EC 1.2.1.68                      coniferyl-aldehyde dehydrogenase 
                EC 1.2.1.69                      fluoroacetaldehyde dehydrogenase 
                EC 1.2.1.70                      glutamyl-tRNA reductase 
                EC 1.2.1.71                      succinylglutamate-semialdehyde dehydrogenase 
                EC 1.2.1.72                      erythrose-4-phosphate dehydrogenase 
                EC 1.2.1.73                      sulfoacetaldehyde dehydrogenase 
                EC 1.2.1.74                      abieta-7,13-dien-18-al dehydrogenase 
                EC 1.2.1.75                      malonyl-CoA reductase (malonate semialdehyde-forming) 
                EC 1.2.1.76                      succinate-semialdehyde dehydrogenase (acylating) 
                EC 1.2.1.77                      3,4-dehydroadipyl-CoA semialdehyde dehydrogenase (NADP+) 
                EC 1.2.1.78                      2-formylbenzoate dehydrogenase 
                EC 1.2.1.79                      succinate-semialdehyde dehydrogenase (NADP+) 
                EC 1.2.1.80                      long-chain acyl-[acyl-carrier-protein] reductase 
                EC 1.2.1.81                      sulfoacetaldehyde dehydrogenase (acylating) 
                EC 1.2.1.82                      β-apo-4′-carotenal oxygenase 
                EC 1.2.1.83                      3-succinoylsemialdehyde-pyridine dehydrogenase 
                EC 1.2.1.84                      alcohol-forming fatty acyl-CoA reductase 
                EC 1.2.1.85                      2-hydroxymuconate-6-semialdehyde dehydrogenase 
                EC 1.2.1.86                      geranial dehydrogenase 
                EC 1.2.1.87                      propanal dehydrogenase (CoA-propanoylating) 
                EC 1.2.1.88                      L-glutamate γ-semialdehyde dehydrogenase 
                EC 1.2.1.89                      D-glyceraldehyde dehydrogenase (NADP+) 
                EC 1.2.1.90                      glyceraldehyde-3-phosphate dehydrogenase [NAD(P)+] 
                EC 1.2.1.91                      3-oxo-5,6-dehydrosuberyl-CoA semialdehyde dehydrogenase 
                EC 1.2.1.92                      3,6-anhydro-α-L-galactose dehydrogenase 
                EC 1.2.1.93                      formate dehydrogenase (NAD+, ferredoxin) 
                EC 1.2.1.94                      farnesal dehydrogenase 
                EC 1.2.1.95                      L-2-aminoadipate reductase 
                EC 1.2.1.96                      4-hydroxybenzaldehyde dehydrogenase (NADP+) 
                EC 1.2.1.97                      3-sulfolactaldehyde dehydrogenase 
                EC 1.2.1.98                      2-hydroxy-2-methylpropanal dehydrogenase 
        EC 1.2.2       []    With a cytochrome as acceptor 
                EC 1.2.2.1                      formate dehydrogenase (cytochrome) 
                EC 1.2.2.2                      pyruvate dehydrogenase (cytochrome). Now covered by EC 1.2.5.1, pyruvate dehydrogenase (quinone) 
                EC 1.2.2.3                      formate dehydrogenase (cytochrome-c-553) 
                EC 1.2.2.4                      carbon-monoxide dehydrogenase (cytochrome b-561) 
        EC 1.2.3       []    With oxygen as acceptor 
                EC 1.2.3.1                      aldehyde oxidase 
                EC 1.2.3.2                      xanthine oxidase. Now EC 1.17.3.2, xanthine oxidase 
                EC 1.2.3.3                      pyruvate oxidase 
                EC 1.2.3.4                      oxalate oxidase 
                EC 1.2.3.5                      glyoxylate oxidase 
                EC 1.2.3.6                      pyruvate oxidase (CoA-acetylating) 
                EC 1.2.3.7                      indole-3-acetaldehyde oxidase 
                EC 1.2.3.8                      pyridoxal oxidase 
                EC 1.2.3.9                      aryl-aldehyde oxidase 
                EC 1.2.3.10                      carbon-monoxide oxidase. Activity due to EC 1.2.2.4 carbon-monoxide dehydrogenase (cytochrome b-561) 
                EC 1.2.3.11                      retinal oxidase. Now included with EC 1.2.3.1, aldehyde oxidase 
                EC 1.2.3.12                      vanillate demethylase. Now EC 1.14.13.82, vanillate monooxygenase 
                EC 1.2.3.13                      4-hydroxyphenylpyruvate oxidase 
                EC 1.2.3.14                      abscisic-aldehyde oxidase 
                EC 1.2.3.15                      (methyl)glyoxal oxidase 
        EC 1.2.4       []    With a disulfide as acceptor 
                EC 1.2.4.1                      pyruvate dehydrogenase (acetyl-transferring) 
                EC 1.2.4.2                      oxoglutarate dehydrogenase (succinyl-transferring) 
                EC 1.2.4.3                       2-oxoisocaproate dehydrogenase. Now included with EC 1.2.4.4, 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) 
                EC 1.2.4.4                      3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) 
        EC 1.2.5       []    With a quinone or similar compound as acceptor 
                EC 1.2.5.1                      pyruvate dehydrogenase (quinone) 
                EC 1.2.5.2                      aldehyde dehydrogenase (quinone) 
                EC 1.2.5.3                      aerobic carbon monoxide dehydrogenase 
        EC 1.2.7       []    With an iron-sulfur protein as acceptor 
                EC 1.2.7.1                      pyruvate synthase 
                EC 1.2.7.2                      2-oxobutyrate synthase. Now included with EC 1.2.7.1, pyruvate synthase. 
                EC 1.2.7.3                      2-oxoglutarate synthase 
                EC 1.2.7.4                      anaerobic carbon-monoxide dehydrogenase 
                EC 1.2.7.5                      aldehyde ferredoxin oxidoreductase 
                EC 1.2.7.6                      glyceraldehyde-3-phosphate dehydrogenase (ferredoxin) 
                EC 1.2.7.7                      3-methyl-2-oxobutanoate dehydrogenase (ferredoxin) 
                EC 1.2.7.8                      indolepyruvate ferredoxin oxidoreductase 
                EC 1.2.7.9                      2-oxoglutarate ferredoxin oxidoreductase. This enzyme is identical to EC 1.2.7.3, 2-oxoglutarate synthase 
                EC 1.2.7.10                      oxalate oxidoreductase 
                EC 1.2.7.11                      2-oxoacid oxidoreductase (ferredoxin) 
        EC 1.2.99       []    With unknown physiological acceptors 
                EC 1.2.99.1                      uracil dehydrogenase. Now EC 1.17.99.4, uracil/thymine dehydrogenase 
                EC 1.2.99.2                      carbon-monoxide dehydrogenase (acceptor). Now EC 1.2.7.4, carbon-monoxide dehydrogenase (ferredoxin)  
                EC 1.2.99.3                      aldehyde dehydrogenase (pyrroloquinoline-quinone). Now EC 1.2.5.2, aldehyde dehydrogenase (quinone) 
                EC 1.2.99.4                      formaldehyde dismutase. Now EC 1.2.98.1, formaldehyde dismutase. 
                EC 1.2.99.5                      formylmethanofuran dehydrogenase 
                EC 1.2.99.6                      carboxylate reductase 
                EC 1.2.99.7                      aldehyde dehydrogenase (FAD-independent) 
                EC 1.2.99.8                      glyceraldehyde dehydrogenase (FAD-containing)  
                EC 1.2.99.9                      formate dehydrogenase (coenzyme F420) 
    EC 1.3  [+]      
        EC 1.3.1       []    With NAD+ or NADP+ as acceptor 
                EC 1.3.1.1                      dihydropyrimidine dehydrogenase (NAD+) 
                EC 1.3.1.2                      dihydropyrimidine dehydrogenase (NADP+) 
                EC 1.3.1.3                      Δ4-3-oxosteroid 5β-reductase 
                EC 1.3.1.4                      EC 1.3.1.4, cortisone α-reductase, transferred to EC 1.3.1.22, 3-oxo-5α-steroid 4-dehydrogenase (NADP+) 
                EC 1.3.1.5                      cucurbitacin Δ23-reductase 
                EC 1.3.1.6                      fumarate reductase (NADH) 
                EC 1.3.1.7                      meso-tartrate dehydrogenase 
                EC 1.3.1.8                      acyl-CoA dehydrogenase (NADP+) 
                EC 1.3.1.9                      enoyl-[acyl-carrier-protein] reductase (NADH) 
                EC 1.3.1.10                      enoyl-[acyl-carrier-protein] reductase (NADPH, Si-specific) 
                EC 1.3.1.11                      2-coumarate reductase 
                EC 1.3.1.12                      prephenate dehydrogenase 
                EC 1.3.1.13                      prephenate dehydrogenase (NADP+) 
                EC 1.3.1.14                      dihydroorotate dehydrogenase (NAD+) 
                EC 1.3.1.15                      dihydroorotate dehydrogenase (NADP+) 
                EC 1.3.1.16                      β-nitroacrylate reductase 
                EC 1.3.1.17                      3-methyleneoxindole reductase 
                EC 1.3.1.18                      kynurenate-7,8-dihydrodiol dehydrogenase 
                EC 1.3.1.19                      cis-1,2-dihydrobenzene-1,2-diol dehydrogenase 
                EC 1.3.1.20                      trans-1,2-dihydrobenzene-1,2-diol dehydrogenase 
                EC 1.3.1.21                      7-dehydrocholesterol reductase 
                EC 1.3.1.22                      3-oxo-5α-steroid 4-dehydrogenase (NADP+) 
                EC 1.3.1.23                       cholestenone β-reductase. The enzyme is identical to EC 1.3.1.3, Δ4-3-oxosteroid 5β-reductase 
                EC 1.3.1.24                      biliverdin reductase 
                EC 1.3.1.25                      1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase 
                EC 1.3.1.26                      dihydrodipicolinate reductase. Now EC 1.17.1.8, 4-hydroxy-tetrahydrodipicolinate reductase. 
                EC 1.3.1.27                      2-hexadecenal reductase 
                EC 1.3.1.28                      2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase 
                EC 1.3.1.29                      cis-1,2-dihydro-1,2-dihydroxynaphthalene dehydrogenase 
                EC 1.3.1.30                      EC 1.3.1.30, progesterone 5α-reductase, transferred to EC 1.3.1.22, 3-oxo-5α-steroid 4-dehydrogenase (NADP+). 
                EC 1.3.1.31                      2-enoate reductase 
                EC 1.3.1.32                      maleylacetate reductase 
                EC 1.3.1.33                      protochlorophyllide reductase 
                EC 1.3.1.34                      2,4-dienoyl-CoA reductase (NADPH) 
                EC 1.3.1.35                      phosphatidylcholine desaturase. Now EC 1.14.19.22, microsomal oleoyl-lipid 12-desaturase 
                EC 1.3.1.36                      geissoschizine dehydrogenase 
                EC 1.3.1.37                      cis-2-enoyl-CoA reductase (NADPH) 
                EC 1.3.1.38                      trans-2-enoyl-CoA reductase (NADPH) 
                EC 1.3.1.39                      enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific) 
                EC 1.3.1.40                      2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate reductase 
                EC 1.3.1.41                      xanthommatin reductase 
                EC 1.3.1.42                      12-oxophytodienoate reductase 
                EC 1.3.1.43                      arogenate dehydrogenase 
                EC 1.3.1.44                      trans-2-enoyl-CoA reductase (NAD+) 
                EC 1.3.1.45                      2′-hydroxyisoflavone reductase 
                EC 1.3.1.46                      biochanin-A reductase 
                EC 1.3.1.47                      α-santonin 1,2-reductase 
                EC 1.3.1.48                      13,14-dehydro-15-oxoprostaglandin 13-reductase 
                EC 1.3.1.49                      cis-3,4-dihydrophenanthrene-3,4-diol dehydrogenase 
                EC 1.3.1.50                       tetrahydroxynaphthalene reductase. Now EC 1.1.1.252 tetrahydroxynaphthalene reductase 
                EC 1.3.1.51                      2′-hydroxydaidzein reductase 
                EC 1.3.1.52                      2-methyl-branched-chain-enoyl-CoA reductase. Now EC 1.3.8.5, 2-methyl-branched-chain-enoyl-CoA reductase 
                EC 1.3.1.53                      (3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate dehydrogenase 
                EC 1.3.1.54                      precorrin-6A reductase 
                EC 1.3.1.55                       cis-1,2-dihydroxycyclohexa-3,5-diene-1-carboxylate dehydrogenase. Enzyme is identical to EC 1.3.1.25, 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase 
                EC 1.3.1.56                      cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase 
                EC 1.3.1.57                      phloroglucinol reductase 
                EC 1.3.1.58                      2,3-dihydroxy-2,3-dihydro-p-cumate dehydrogenase 
                EC 1.3.1.59                      1,2-dihydroxy-3-methyl-1,2-dihydrobenzoate dehydrogenase. No evidence in the paper cited that the enzyme exists 
                EC 1.3.1.60                      dibenzothiophene dihydrodiol dehydrogenase 
                EC 1.3.1.61                      terephthalate 1,2-cis-dihydrodiol dehydrogenase. Enzyme is identical to EC 1.3.1.53, (3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate dehydrogenase 
                EC 1.3.1.62                      pimeloyl-CoA dehydrogenase 
                EC 1.3.1.63                      2,4-dichlorobenzoyl-CoA reductase. Now EC 1.21.1.2, 2,4-dichlorobenzoyl-CoA reductase 
                EC 1.3.1.64                      phthalate 4,5-cis-dihydrodiol dehydrogenase 
                EC 1.3.1.65                      5,6-dihydroxy-3-methyl-2-oxo-1,2,5,6-tetrahydroquinoline dehydrogenase 
                EC 1.3.1.66                      cis-dihydroethylcatechol dehydrogenase 
                EC 1.3.1.67                      cis-1,2-dihydroxy-4-methylcyclohexa-3,5-diene-1-carboxylate dehydrogenase 
                EC 1.3.1.68                      1,2-dihydroxy-6-methylcyclohexa-3,5-dienecarboxylate dehydrogenase 
                EC 1.3.1.69                      zeatin reductase 
                EC 1.3.1.70                      Δ14-sterol reductase 
                EC 1.3.1.71                      Δ24(241)-sterol reductase 
                EC 1.3.1.72                      Δ24-sterol reductase 
                EC 1.3.1.73                      1,2-dihydrovomilenine reductase 
                EC 1.3.1.74                      2-alkenal reductase [NAD(P)+] 
                EC 1.3.1.75                      3,8-divinyl protochlorophyllide a 8-vinyl-reductase (NADPH) 
                EC 1.3.1.76                      precorrin-2 dehydrogenase 
                EC 1.3.1.77                      anthocyanidin reductase [(2R,3R)-flavan-3-ol-forming] 
                EC 1.3.1.78                      arogenate dehydrogenase (NADP+) 
                EC 1.3.1.79                      arogenate dehydrogenase [NAD(P)+] 
                EC 1.3.1.80                      red chlorophyll catabolite reductase. Now classified as EC 1.3.7.12, red chlorophyll catabolite reductase 
                EC 1.3.1.81                      (+)-pulegone reductase 
                EC 1.3.1.82                      (-)-isopiperitenone reductase 
                EC 1.3.1.83                      geranylgeranyl diphosphate reductase 
                EC 1.3.1.84                      acrylyl-CoA reductase (NADPH) 
                EC 1.3.1.85                      crotonyl-CoA carboxylase/reductase 
                EC 1.3.1.86                      crotonyl-CoA reductase 
                EC 1.3.1.87                      3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate dehydrogenase 
                EC 1.3.1.88                      tRNA-dihydrouridine16/17 synthase [NAD(P)+] 
                EC 1.3.1.89                      tRNA-dihydrouridine47 synthase [NAD(P)+] 
                EC 1.3.1.90                      tRNA-dihydrouridine20a/20b synthase [NAD(P)+] 
                EC 1.3.1.91                      tRNA-dihydrouridine20 synthase [NAD(P)+] 
                EC 1.3.1.92                      artemisinic aldehyde Δ11(13)-reductase 
                EC 1.3.1.93                      very-long-chain enoyl-CoA reductase 
                EC 1.3.1.94                      polyprenol reductase 
                EC 1.3.1.95                      acrylyl-CoA reductase (NADH) 
                EC 1.3.1.96                      Botryococcus squalene synthase 
                EC 1.3.1.97                      botryococcene synthase 
                EC 1.3.1.98                      UDP-N-acetylmuramate dehydrogenase 
                EC 1.3.1.99                      iridoid synthase 
                EC 1.3.1.100                      chanoclavine-I aldehyde reductase 
                EC 1.3.1.101                      2,3-bis-O-geranylgeranyl-sn-glycerol 1-phosphate reductase [NAD(P)H] 
                EC 1.3.1.102                      2-alkenal reductase (NADP+) 
                EC 1.3.1.103                      2-haloacrylate reductase 
                EC 1.3.1.104                      enoyl-[acyl-carrier-protein] reductase (NADPH) 
                EC 1.3.1.105                      2-methylene-furan-3-one reductase 
                EC 1.3.1.106                      cobalt-precorrin-6A reductase 
                EC 1.3.1.107                      sanguinarine reductase 
                EC 1.3.1.108                      caffeoyl-CoA reductase 
                EC 1.3.1.109                      butanoyl-CoA dehydrogenase (NAD+, ferredoxin) 
                EC 1.3.1.110                      lactate dehydrogenase (NAD+,ferredoxin) 
                EC 1.3.1.111                      geranylgeranyl-bacteriochlorophyllide a reductase 
                EC 1.3.1.112                      anthocyanidin reductase [(2S)-flavan-3-ol-forming] 
        EC 1.3.2       []    With a cytochrome as acceptor 
                EC 1.3.2.1                      butyryl-CoA dehydrogenase. Now EC 1.3.99.2, butyryl-CoA dehydrogenase 
                EC 1.3.2.2                      acyl-CoA dehydrogenase. Now EC 1.3.99.3, acyl-CoA dehydrogenase 
                EC 1.3.2.3                      L-galactonolactone dehydrogenase 
        EC 1.3.3       []    With oxygen as acceptor 
                EC 1.3.3.1                      dihydroorotate oxidase. Now EC 1.3.98.1 [dihydroorotate dehydrogenase (fumarate)] 
                EC 1.3.3.2                      now EC 1.14.21.6, lathosterol oxidase. NAD(P)H had not been included previously, so enzyme had to be reclassified 
                EC 1.3.3.3                      coproporphyrinogen oxidase 
                EC 1.3.3.4                      protoporphyrinogen oxidase 
                EC 1.3.3.5                      bilirubin oxidase 
                EC 1.3.3.6                      acyl-CoA oxidase 
                EC 1.3.3.7                      dihydrouracil oxidase 
                EC 1.3.3.8                      tetrahydroberberine oxidase 
                EC 1.3.3.9                      secologanin synthase 
                EC 1.3.3.10                      tryptophan α,β-oxidase 
                EC 1.3.3.11                      pyrroloquinoline-quinone synthase 
                EC 1.3.3.12                      L-galactonolactone oxidase 
                EC 1.3.3.13                      albonoursin synthase 
                EC 1.3.3.14                      aclacinomycin-A oxidase 
                EC 1.3.3.15                      coproporphyrinogen III oxidase (coproporphyrin-forming) 
        EC 1.3.4       []    With a disulfide as acceptor 
                EC 1.3.4.1                      fumarate reductase (CoM/CoB) 
        EC 1.3.5       []    With a quinone or related compound as acceptor 
                EC 1.3.5.1                      succinate dehydrogenase 
                EC 1.3.5.2                      dihydroorotate dehydrogenase (quinone) 
                EC 1.3.5.3                      protoporphyrinogen IX dehydrogenase (menaquinone) 
                EC 1.3.5.4                      fumarate reductase (quinol) 
                EC 1.3.5.5                      15-cis-phytoene desaturase 
                EC 1.3.5.6                      9,9′-dicis-ζ-carotene desaturase 
        EC 1.3.7       []    With an iron-sulfur protein as acceptor 
                EC 1.3.7.1                      6-hydroxynicotinate reductase 
                EC 1.3.7.2                      15,16-dihydrobiliverdin:ferredoxin oxidoreductase 
                EC 1.3.7.3                      phycoerythrobilin:ferredoxin oxidoreductase 
                EC 1.3.7.4                      phytochromobilin:ferredoxin oxidoreductase 
                EC 1.3.7.5                      phycocyanobilin:ferredoxin oxidoreductase 
                EC 1.3.7.6                      phycoerythrobilin synthase 
                EC 1.3.7.7                      ferredoxin:protochlorophyllide reductase (ATP-dependent) 
                EC 1.3.7.8                      benzoyl-CoA reductase 
                EC 1.3.7.9                      4-hydroxybenzoyl-CoA reductase 
                EC 1.3.7.10                      pentalenolactone synthase. Now EC 1.14.19.8, pentalenolactone synthase 
                EC 1.3.7.11                      2,3-bis-O-geranylgeranyl-sn-glycero-phospholipid reductase 
                EC 1.3.7.12                      red chlorophyll catabolite reductase 
                EC 1.3.7.13                      3,8-divinyl protochlorophyllide a 8-vinyl-reductase (ferredoxin) 
                EC 1.3.7.14                      3,8-divinyl chlorophyllide a reductase 
                EC 1.3.7.15                      chlorophyllide a reductase 
        EC 1.3.8       []    With a flavin as acceptor 
                EC 1.3.8.1                      short-chain acyl-CoA dehydrogenase 
                EC 1.3.8.2                      4,4′-diapophytoene desaturase (4,4′-diapolycopene-forming) 
                EC 1.3.8.3                      (R)-benzylsuccinyl-CoA dehydrogenase 
                EC 1.3.8.4                      isovaleryl-CoA dehydrogenase 
                EC 1.3.8.5                      2-methyl-branched-chain-enoyl-CoA reductase 
                EC 1.3.8.6                      glutaryl-CoA dehydrogenase (ETF) 
                EC 1.3.8.7                      medium-chain acyl-CoA dehydrogenase 
                EC 1.3.8.8                      long-chain acyl-CoA dehydrogenase 
                EC 1.3.8.9                      very-long-chain acyl-CoA dehydrogenase 
                EC 1.3.8.10                      cyclohex-1-ene-1-carbonyl-CoA dehydrogenase 
                EC 1.3.8.11                      cyclohexane-1-carbonyl-CoA dehydrogenase 
                EC 1.3.8.12                      (2S)-methylsuccinyl-CoA dehydrogenase 
                EC 1.3.8.13                      crotonobetainyl-CoA reductase 
        EC 1.3.98       []    With other, known, physiological acceptors 
                EC 1.3.98.1                      dihydroorotate dehydrogenase (fumarate) 
                EC 1.3.98.2                      fumarate reductase (CoM/CoB). Now EC 1.3.4.1, fumarate reductase (CoM/CoB) 
                EC 1.3.98.3                      coproporphyrinogen dehydrogenase 
                EC 1.3.98.4                      5a,11a-dehydrotetracycline reductase 
        EC 1.3.99       []    With unknown physiological acceptors 
                EC 1.3.99.1                      succinate dehydrogenase. The activity is included in EC 1.3.5.1, succinate dehydrogenase (quinone). 
                EC 1.3.99.2                      butyryl-CoA dehydrogenase. Now EC 1.3.8.1, butyryl-CoA dehydrogenase. 
                EC 1.3.99.3                      acyl-CoA dehydrogenase, now EC 1.3.8.7, medium-chain acyl-CoA dehydrogenase, EC 1.3.8.8, long-chain acyl-CoA dehydrogenase and EC 1.3.8.9, very-long-chain acyl-CoA dehydrogenase 
                EC 1.3.99.4                      3-oxosteroid 1-dehydrogenase 
                EC 1.3.99.5                      3-oxo-5α-steroid 4-dehydrogenase (acceptor) 
                EC 1.3.99.6                      3-oxo-5β-steroid 4-dehydrogenase 
                EC 1.3.99.7                      glutaryl-CoA dehydrogenase. Now EC 1.3.8.6, glutaryl-CoA dehydrogenase 
                EC 1.3.99.8                      2-furoyl-CoA dehydrogenase 
                EC 1.3.99.9                      β-cyclopiazonate dehydrogenase. Now EC 1.21.99.1, β-cyclopiazonate dehydrogenase 
                EC 1.3.99.10                      isovaleryl-CoA dehydrogenase. Now EC 1.3.8.4, isovaleryl-CoA dehydrogenase 
                EC 1.3.99.11                      dihydroorotate dehydrogenase. As the acceptor is now known, the enzyme has been transferred to EC 1.3.5.2, dihydroorotate dehydrogenase 
                EC 1.3.99.12                      2-methylacyl-CoA dehydrogenase 
                EC 1.3.99.13                      long-chain-acyl-CoA dehydrogenase. Now EC 1.3.8.8, long-chain-acyl-CoA dehydrogenase 
                EC 1.3.99.14                      cyclohexanone dehydrogenase 
                EC 1.3.99.15                      benzoyl-CoA reductase. Now EC 1.3.7.8. 
                EC 1.3.99.16                      isoquinoline 1-oxidoreductase 
                EC 1.3.99.17                      quinoline 2-oxidoreductase 
                EC 1.3.99.18                      quinaldate 4-oxidoreductase 
                EC 1.3.99.19                      quinoline-4-carboxylate 2-oxidoreductase 
                EC 1.3.99.20                      EC 1.3.99.20, 4-hydroxybenzoyl-CoA reductase. Now EC 1.3.7.9, 4-hydroxybenzoyl-CoA reductase. 
                EC 1.3.99.21                      (R)-benzylsuccinyl-CoA dehydrogenase. Now EC 1.3.8.3, (R)-benzylsuccinyl-CoA dehydrogenase 
                EC 1.3.99.22                      coproporphyrinogen dehydrogenase. Now EC 1.3.98.3, coproporphyrinogen dehydrogenase 
                EC 1.3.99.23                      all-trans-retinol 13,14-reductase 
                EC 1.3.99.24                      2-amino-4-deoxychorismate dehydrogenase 
                EC 1.3.99.25                      carvone reductase 
                EC 1.3.99.26                      all-trans-ζ-carotene desaturase 
                EC 1.3.99.27                      1-hydroxycarotenoid 3,4-desaturase 
                EC 1.3.99.28                      phytoene desaturase (neurosporene-forming) 
                EC 1.3.99.29                      phytoene desaturase (ζ-carotene-forming) 
                EC 1.3.99.30                      phytoene desaturase (3,4-didehydrolycopene-forming) 
                EC 1.3.99.31                      phytoene desaturase (lycopene-forming) 
                EC 1.3.99.32                      glutaryl-CoA dehydrogenase (acceptor) 
                EC 1.3.99.33                      urocanate reductase 
                EC 1.3.99.34                      2,3-bis-O-geranylgeranyl-sn-glycerol 1-phosphate reductase (donor). Now classified as EC 1.3.7.11, 2,3-bis-O-geranylgeranyl-sn-glycero-phospholipid reductase. 
                EC 1.3.99.35                      chlorophyllide a reductase. Now EC 1.3.7.15, chlorophyllide a reductase 
                EC 1.3.99.36                      cypemycin cysteine dehydrogenase (decarboxylating) 
                EC 1.3.99.37                      1-hydroxy-2-isopentenylcarotenoid 3,4-desaturase 
                EC 1.3.99.38                      menaquinone-9 β-reductase 
    EC 1.4  [+]      
        EC 1.4.1       []    With NAD+ or NADP+ as acceptor 
                EC 1.4.1.1                      alanine dehydrogenase 
                EC 1.4.1.2                      glutamate dehydrogenase 
                EC 1.4.1.3                      glutamate dehydrogenase [NAD(P)+] 
                EC 1.4.1.4                      glutamate dehydrogenase (NADP+) 
                EC 1.4.1.5                      L-amino-acid dehydrogenase 
                EC 1.4.1.6                      D-proline reductase. Now included with EC 1.21.4.1, D-proline reductase (dithiol) 
                EC 1.4.1.7                      serine 2-dehydrogenase 
                EC 1.4.1.8                      valine dehydrogenase (NADP+) 
                EC 1.4.1.9                      leucine dehydrogenase 
                EC 1.4.1.10                      glycine dehydrogenase 
                EC 1.4.1.11                      L-erythro-3,5-diaminohexanoate dehydrogenase 
                EC 1.4.1.12                      2,4-diaminopentanoate dehydrogenase 
                EC 1.4.1.13                      glutamate synthase (NADPH) 
                EC 1.4.1.14                      glutamate synthase (NADH) 
                EC 1.4.1.15                      lysine dehydrogenase 
                EC 1.4.1.16                      diaminopimelate dehydrogenase 
                EC 1.4.1.17                      N-methylalanine dehydrogenase 
                EC 1.4.1.18                      lysine 6-dehydrogenase 
                EC 1.4.1.19                      tryptophan dehydrogenase 
                EC 1.4.1.20                      phenylalanine dehydrogenase 
                EC 1.4.1.21                      aspartate dehydrogenase 
                EC 1.4.1.22                      ornithine cyclodeaminase. It was pointed out during the public-review process that there is no overall consumption of NAD+ during the reaction. As a result, transfer of the enzyme from EC 4.3.1.12 was not necessary and EC 1.4.1.22 was withdrawn before being made official 
                EC 1.4.1.23                      valine dehydrogenase (NAD+) 
                EC 1.4.1.24                      3-dehydroquinate synthase II 
                EC 1.4.1.25                      L-arginine dehydrogenase 
                EC 1.4.1.26                      2,4-diaminopentanoate dehydrogenase (NAD+) 
        EC 1.4.2       []    With a cytochrome as acceptor 
                EC 1.4.2.1                      glycine dehydrogenase (cytochrome) 
        EC 1.4.3       []    With oxygen as acceptor 
                EC 1.4.3.1                      D-aspartate oxidase 
                EC 1.4.3.2                      L-amino-acid oxidase 
                EC 1.4.3.3                      D-amino-acid oxidase 
                EC 1.4.3.4                      monoamine oxidase 
                EC 1.4.3.5                      pyridoxal 5′-phosphate synthase 
                EC 1.4.3.6                      amine oxidase (copper-containing). This was classified on the basis of cofactor content rather than reaction catalysed and is now known to contain two distinct enzyme activities. It has been replaced by two enzymes, EC 1.4.3.21 (primary-amine oxidase) and EC 1.4.3.22 (diamine oxidase) 
                EC 1.4.3.7                      D-glutamate oxidase 
                EC 1.4.3.8                      ethanolamine oxidase 
                EC 1.4.3.9                       tyramine oxidase. Now included with EC 1.4.3.4 amine oxidase (flavin-containing) 
                EC 1.4.3.10                      putrescine oxidase 
                EC 1.4.3.11                      L-glutamate oxidase 
                EC 1.4.3.12                      cyclohexylamine oxidase 
                EC 1.4.3.13                      protein-lysine 6-oxidase 
                EC 1.4.3.14                      L-lysine oxidase 
                EC 1.4.3.15                      D-glutamate(D-aspartate) oxidase 
                EC 1.4.3.16                      L-aspartate oxidase 
                EC 1.4.3.17                      tryptophan α,β-oxidase. Now EC 1.3.3.10, tryptophan α,β-oxidase. Enzyme was incorrectly classified as acting on a CH-NH bond rather than a CH-CH bond 
                EC 1.4.3.18                      cytokinin oxidase. Not approved as the enzyme was shown to be a dehydrogenase and not an oxidase (see EC 1.5.99.12, cytokinin dehydrogenase) 
                EC 1.4.3.19                      glycine oxidase 
                EC 1.4.3.20                      L-lysine 6-oxidase 
                EC 1.4.3.21                      primary-amine oxidase 
                EC 1.4.3.22                      diamine oxidase 
                EC 1.4.3.23                      7-chloro-L-tryptophan oxidase 
                EC 1.4.3.24                      pseudooxynicotine oxidase 
                EC 1.4.3.25                      L-arginine oxidase 
        EC 1.4.4       []    With a disulfide as acceptor 
                EC 1.4.4.1                      D-proline reductase (dithiol). Now EC 1.21.4.1, D-proline reductase (dithiol) 
                EC 1.4.4.2                      glycine dehydrogenase (aminomethyl-transferring) 
        EC 1.4.5       []    With a quinone or other compound as acceptor 
                EC 1.4.5.1                      D-amino acid dehydrogenase (quinone) 
        EC 1.4.7       []    With an iron-sulfur protein as acceptor 
                EC 1.4.7.1                      glutamate synthase (ferredoxin) 
        EC 1.4.9       []    With a copper protein as acceptor 
                EC 1.4.9.1                      methylamine dehydrogenase (amicyanin) 
                EC 1.4.9.2                      aralkylamine dehydrogenase (azurin) 
        EC 1.4.99       []    With unknown physiological acceptors 
                EC 1.4.99.1                      D-amino-acid dehydrogenase. Now listed as EC 1.4.99.6, D-arginine dehydrogenase 
                EC 1.4.99.2                      taurine dehydrogenase 
                EC 1.4.99.3                      amine dehydrogenase. Now EC 1.4.9.1, methylamine dehydrogenase (amicyanin) 
                EC 1.4.99.4                      aralkylamine dehydrogenase. Now EC 1.4.9.2, aralkylamine dehydrogenase (azurin) 
                EC 1.4.99.5                      glycine dehydrogenase (cyanide-forming) 
                EC 1.4.99.6                      D-arginine dehydrogenase 
    EC 1.5  [+]      
        EC 1.5.1       []    With NAD+ or NADP+ as acceptor 
                EC 1.5.1.1                      1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase [NAD(P)H] 
                EC 1.5.1.2                      pyrroline-5-carboxylate reductase 
                EC 1.5.1.3                      dihydrofolate reductase 
                EC 1.5.1.4                       dihydrofolate dehydrogenase. Now included with EC 1.5.1.3 dihydrofolate reductase 
                EC 1.5.1.5                      methylenetetrahydrofolate dehydrogenase (NADP+) 
                EC 1.5.1.6                      formyltetrahydrofolate dehydrogenase 
                EC 1.5.1.7                      saccharopine dehydrogenase (NAD+, L-lysine-forming) 
                EC 1.5.1.8                      saccharopine dehydrogenase (NADP+, L-lysine-forming) 
                EC 1.5.1.9                      saccharopine dehydrogenase (NAD+, L-glutamate-forming) 
                EC 1.5.1.10                      saccharopine dehydrogenase (NADP+, L-glutamate-forming) 
                EC 1.5.1.11                      D-octopine dehydrogenase 
                EC 1.5.1.12                      1-pyrroline-5-carboxylate dehydrogenase. Now EC 1.2.1.88, L-glutamate γ-semialdehyde dehydrogenase.  
                EC 1.5.1.13                      nicotinate dehydrogenase. Now EC 1.17.1.5, nicotinate dehydrogenase. The enzyme was incorrectly classified as acting on a CH-NH group 
                EC 1.5.1.14                       1,2-didehydropipecolate reductase. Now included with EC 1.5.1.21 Δ1-piperideine-2-carboxylate reductase 
                EC 1.5.1.15                      methylenetetrahydrofolate dehydrogenase (NAD+) 
                EC 1.5.1.16                      D-lysopine dehydrogenase 
                EC 1.5.1.17                      alanopine dehydrogenase 
                EC 1.5.1.18                      ephedrine dehydrogenase 
                EC 1.5.1.19                      D-nopaline dehydrogenase 
                EC 1.5.1.20                      methylenetetrahydrofolate reductase [NAD(P)H] 
                EC 1.5.1.21                      1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase (NADPH) 
                EC 1.5.1.22                      strombine dehydrogenase 
                EC 1.5.1.23                      tauropine dehydrogenase 
                EC 1.5.1.24                      N5-(carboxyethyl)ornithine synthase 
                EC 1.5.1.25                      thiomorpholine-carboxylate dehydrogenase 
                EC 1.5.1.26                      β-alanopine dehydrogenase 
                EC 1.5.1.27                      1,2-dehydroreticulinium reductase (NADPH) 
                EC 1.5.1.28                      opine dehydrogenase 
                EC 1.5.1.29                      FMN reductase [NAD(P)H]. Now covered by EC 1.5.1.38 [FMN reductase (NADPH)], EC 1.5.1.39 [FMN reductase [NAD(P)H])] and EC 1.5.1.41 (riboflavin reductase [NAD(P)H]) 
                EC 1.5.1.30                      flavin reductase (NADPH) 
                EC 1.5.1.31                      berberine reductase 
                EC 1.5.1.32                      vomilenine reductase 
                EC 1.5.1.33                      pteridine reductase 
                EC 1.5.1.34                      6,7-dihydropteridine reductase 
                EC 1.5.1.35                      1-pyrroline dehydrogenase. The enzyme is identical to EC 1.2.1.19, aminobutyraldehyde dehydrogenase, as the substrates 1-pyrroline and 4-aminobutanal are interconvertible 
                EC 1.5.1.36                      flavin reductase (NADH) 
                EC 1.5.1.37                      FAD reductase (NADH) 
                EC 1.5.1.38                      FMN reductase (NADPH) 
                EC 1.5.1.39                      FMN reductase [NAD(P)H] 
                EC 1.5.1.40                      8-hydroxy-5-deazaflavin:NADPH oxidoreductase 
                EC 1.5.1.41                      riboflavin reductase [NAD(P)H] 
                EC 1.5.1.42                      FMN reductase (NADH) 
                EC 1.5.1.43                      carboxynorspermidine synthase 
                EC 1.5.1.44                      festuclavine dehydrogenase 
                EC 1.5.1.45                      FAD reductase [NAD(P)H] 
                EC 1.5.1.46                      agroclavine dehydrogenase 
                EC 1.5.1.47                      dihydromethanopterin reductase [NAD(P)+] 
                EC 1.5.1.48                      2-methyl-1-pyrroline reductase 
                EC 1.5.1.49                      1-pyrroline-2-carboxylate reductase [NAD(P)H] 
                EC 1.5.1.50                      dihydromonapterin reductase 
                EC 1.5.1.51                      N-[(2S)-2-amino-2-carboxyethyl]-L-glutamate dehydrogenase 
        EC 1.5.3       []    With oxygen as acceptor 
                EC 1.5.3.1                      sarcosine oxidase 
                EC 1.5.3.2                      N-methyl-L-amino-acid oxidase 
                EC 1.5.3.3                       spermine oxidase 
                EC 1.5.3.4                      N6-methyl-lysine oxidase 
                EC 1.5.3.5                      (S)-6-hydroxynicotine oxidase 
                EC 1.5.3.6                      (R)-6-hydroxynicotine oxidase 
                EC 1.5.3.7                      L-pipecolate oxidase 
                EC 1.5.3.8                      (S)-tetrahydroprotoberberine oxidase. Now included with EC 1.3.3.8, tetrahydroberberine oxidase 
                EC 1.5.3.9                      reticuline oxidase. Now EC 1.21.3.3, reticuline oxidase 
                EC 1.5.3.10                      dimethylglycine oxidase 
                EC 1.5.3.11                      polyamine oxidase. Now included with EC 1.5.3.13 (N1-acetylpolyamine oxidase), EC 1.5.3.14 (polyamine oxidase (propane-1,3-diamine-forming)), EC 1.5.3.15 (N8-acetylspermidine oxidase (propane-1,3-diamine-forming)), EC 1.5.3.16 (spermine oxidase) and EC 1.5.3.17 (non-specific polyamine oxidase) 
                EC 1.5.3.12                      dihydrobenzophenanthridine oxidase 
                EC 1.5.3.13                      N1-acetylpolyamine oxidase 
                EC 1.5.3.14                      polyamine oxidase (propane-1,3-diamine-forming) 
                EC 1.5.3.15                      N8-acetylspermidine oxidase (propane-1,3-diamine-forming) 
                EC 1.5.3.16                      spermine oxidase 
                EC 1.5.3.17                      non-specific polyamine oxidase 
                EC 1.5.3.18                      L-saccharopine oxidase 
                EC 1.5.3.19                      4-methylaminobutanoate oxidase (formaldehyde-forming) 
                EC 1.5.3.20                      N-alkylglycine oxidase 
                EC 1.5.3.21                      4-methylaminobutanoate oxidase (methylamine-forming) 
                EC 1.5.3.22                      coenzyme F420H2 oxidase  
                EC 1.5.3.23                      glyphosate oxidoreductase 
        EC 1.5.4       []    With a disulfide as acceptor 
                EC 1.5.4.1                      pyrimidodiazepine synthase 
        EC 1.5.5       []    With a quinone or similar compound as acceptor 
                EC 1.5.5.1                      electron-transferring-flavoprotein dehydrogenase 
                EC 1.5.5.2                      proline dehydrogenase 
        EC 1.5.7       []    With an iron-sulfur protein as acceptor 
                EC 1.5.7.1                      methylenetetrahydrofolate reductase (ferredoxin) 
                EC 1.5.7.2                      coenzyme F420 oxidoreductase (ferredoxin) 
        EC 1.5.8       []    With a flavin or flavoprotein as acceptor 
                EC 1.5.8.1                      dimethylamine dehydrogenase 
                EC 1.5.8.2                      trimethylamine dehydrogenase 
                EC 1.5.8.3                      sarcosine dehydrogenase 
                EC 1.5.8.4                      dimethylglycine dehydrogenase 
        EC 1.5.99       []    With unknown physiological acceptors 
                EC 1.5.99.1                      sarcosine dehydrogenase. Now EC 1.5.8.3, sarcosine dehydrogenase 
                EC 1.5.99.2                      dimethylglycine dehydrogenase. Now EC 1.5.8.4, dimethylglycine dehydrogenase 
                EC 1.5.99.3                      L-pipecolate dehydrogenase 
                EC 1.5.99.4                      nicotine dehydrogenase 
                EC 1.5.99.5                      methylglutamate dehydrogenase 
                EC 1.5.99.6                      spermidine dehydrogenase 
                EC 1.5.99.7                      trimethylamine dehydrogenase. Now EC 1.5.8.2, trimethylamine dehydrogenase 
                EC 1.5.99.8                      proline dehydrogenase. Now EC 1.5.5.2, proline dehydrogenase.  
                EC 1.5.99.9                      methylenetetrahydromethanopterin dehydrogenase. As the acceptor is known the enzyme has been transferred to EC 1.5.98.1, methylenetetrahydromethanopterin dehydrogenase 
                EC 1.5.99.10                      dimethylamine dehydrogenase. Now EC 1.5.8.1, dimethylamine dehydrogenase 
                EC 1.5.99.11                      methylenetetrahydromethanopterin dehydrogenase. As the acceptor is known the enzyme has been transferred to EC 1.5.98.2, 5,10-methylenetetrahydromethanopterin reductase 
                EC 1.5.99.12                      cytokinin dehydrogenase 
                EC 1.5.99.13                      D-proline dehydrogenase 
                EC 1.5.99.14                      6-hydroxypseudooxynicotine dehydrogenase 
                EC 1.5.99.15                      dihydromethanopterin reductase (acceptor) 
    EC 1.6  [+]      
        EC 1.6.1       []    With NAD+ or NADP+ as acceptor 
                EC 1.6.1.1                      NAD(P)+ transhydrogenase (Si-specific) 
                EC 1.6.1.2                      NAD(P)+ transhydrogenase (Re/Si-specific) 
                EC 1.6.1.3                      NAD(P)+ transhydrogenase 
                EC 1.6.1.4                      NAD(P)+ transhydrogenase (ferredoxin) 
                EC 1.6.1.5                      proton-translocating NAD(P)+ transhydrogenase 
        EC 1.6.2       []    With a heme protein as acceptor 
                EC 1.6.2.1                      NADH2 cytochrome c reductase. Now EC 1.6.99.3, NADH dehydrogenase 
                EC 1.6.2.2                      cytochrome-b5 reductase 
                EC 1.6.2.3                       cytochrome reductase (NADPH) 
                EC 1.6.2.4                      NADPH—hemoprotein reductase 
                EC 1.6.2.5                      NADPH—cytochrome-c2 reductase 
                EC 1.6.2.6                      leghemoglobin reductase 
        EC 1.6.3       []    With oxygen as acceptor 
                EC 1.6.3.1                      NAD(P)H oxidase (H2O2-forming) 
                EC 1.6.3.2                      NAD(P)H oxidase (H2O-forming) 
                EC 1.6.3.3                      NADH oxidase (H2O2-forming) 
                EC 1.6.3.4                      NADH oxidase (H2O-forming) 
                EC 1.6.3.5                      renalase 
        EC 1.6.4       []    With a disulfide as acceptor (deleted sub-subclass) 
                EC 1.6.4.1                      cystine reductase (NADH). Now EC 1.8.1.6, cystine reductase 
                EC 1.6.4.2                      glutathione reductase (NADPH). Now EC 1.8.1.7, glutathione-disulfide reductase 
                EC 1.6.4.3                      dihydrolipoamide reductase (NAD+). Now EC 1.8.1.4, dihydrolipoyl dehydrogenase 
                EC 1.6.4.4                      protein-disulfide reductase [NAD(P)H]. Now EC 1.8.1.8, protein-disulfide reductase 
                EC 1.6.4.5                      thioredoxin reductase (NADPH). Now EC 1.8.1.9, thioredoxin-disulfide reductase 
                EC 1.6.4.6                      CoA-glutathione reductase (NADPH). Now EC 1.8.1.10, CoA-glutathione reductase 
                EC 1.6.4.7                      asparagusate reductase (NADH). Now EC 1.8.1.11, asparagusate reductase 
                EC 1.6.4.8                      trypanothione reductase. Now EC 1.8.1.12, trypanothione-disulfide reductase 
                EC 1.6.4.9                      bis-γ-glutamylcystine reductase (NADPH). Now EC 1.8.1.13, bis-γ-glutamylcystine reductase 
                EC 1.6.4.10                      CoA-disulfide reductase (NADH). Now EC 1.8.1.14, CoA-disulfide reductase 
        EC 1.6.5       []    With a quinone or similar compound as acceptor 
                EC 1.6.5.1                       quinone reductase 
                EC 1.6.5.2                      NAD(P)H dehydrogenase (quinone) 
                EC 1.6.5.3                      NADH:ubiquinone reductase (H+-translocating) 
                EC 1.6.5.4                      monodehydroascorbate reductase (NADH) 
                EC 1.6.5.5                      NADPH:quinone reductase 
                EC 1.6.5.6                      p-benzoquinone reductase (NADPH) 
                EC 1.6.5.7                      2-hydroxy-1,4-benzoquinone reductase 
                EC 1.6.5.8                      NADH:ubiquinone reductase (Na+-transporting) 
                EC 1.6.5.9                      NADH:ubiquinone reductase (non-electrogenic) 
                EC 1.6.5.10                      NADPH dehydrogenase (quinone) 
                EC 1.6.5.11                      NADH dehydrogenase (quinone) 
                EC 1.6.5.12                      demethylphylloquinone reductase 
        EC 1.6.6       []    With a nitrogenous group as acceptor 
                EC 1.6.6.1                      nitrate reductase (NADH). Now EC 1.7.1.1, nitrate reductase (NADH) 
                EC 1.6.6.2                      nitrate reductase [NAD(P)H]. Now EC 1.7.1.2, nitrate reductase [NAD(P)H] 
                EC 1.6.6.3                      nitrate reductase (NADPH). Now EC 1.7.1.3, nitrate reductase (NADPH) 
                EC 1.6.6.4                      nitrite reductase [NAD(P)H]. Now EC 1.7.1.4, nitrite reductase [NAD(P)H] 
                EC 1.6.6.5                      now EC 1.7.2.1, nitrite reductase (NO-forming) 
                EC 1.6.6.6                      hyponitrite reductase. Now EC 1.7.1.5, hyponitrite reductase 
                EC 1.6.6.7                      azobenzene reductase. Now EC 1.7.1.6, azobenzene reductase 
                EC 1.6.6.8                      GMP reductase. Now EC 1.7.1.7, GMP reductase 
                EC 1.6.6.9                      trimethylamine-N-oxide reductase 
                EC 1.6.6.10                      nitroquinoline-N-oxide reductase. Now EC 1.7.1.9, nitroquinoline-N-oxide reductase 
                EC 1.6.6.11                      hydroxylamine reductase (NADH). Now EC 1.7.1.10, hydroxylamine reductase (NADH) 
                EC 1.6.6.12                      4-(dimethylamino)phenylazoxybenzene reductase. Now EC 1.7.1.11, 4-(dimethylamino)phenylazoxybenzene reductase 
                EC 1.6.6.13                      N-hydroxy-2-acetamidofluorene reductase. Now EC 1.7.1.12, N-hydroxy-2-acetamidofluorene reductase 
        EC 1.6.7       []    With an iron-sulfur protein as acceptor (deleted sub-subclass) 
                EC 1.6.7.1                      ferredoxin—NADP+ reductase. Now EC 1.18.1.2, ferredoxin—NADP+ reductase 
                EC 1.6.7.2                      rubredoxin—NAD+ reductase. Now EC 1.18.1.1, rubredoxin—NAD+ reductase 
                EC 1.6.7.3                      now EC 1.18.1.3, ferredoxin—NAD+ reductase 
        EC 1.6.8       []    With a flavin as acceptor (deleted sub-subclass) 
                EC 1.6.8.1                      NAD(P)H dehydrogenase (FMN). Now EC 1.5.1.29, FMN reductase 
                EC 1.6.8.2                      NADPH dehydrogenase (flavin). Now EC 1.5.1.30, flavin reductase 
        EC 1.6.99       []    With unknown physiological acceptors 
                EC 1.6.99.1                      NADPH dehydrogenase 
                EC 1.6.99.2                      NAD(P)H dehydrogenase (quinone). Now EC 1.6.5.2, NAD(P)H dehydrogenase (quinone). The enzyme was erroneously transferred from this sub-subclass in 1965 
                EC 1.6.99.3                      NADH dehydrogenase 
                EC 1.6.99.4                      nitrite reductase. Now EC 1.18.1.2, ferredoxin—NADP+ reductase 
                EC 1.6.99.5                      NADH dehydrogenase (quinone). Transferred to EC 1.6.5.11, NADH dehydrogenase (quinone) 
                EC 1.6.99.6                      NADPH dehydrogenase (quinone). Now EC 1.6.5.10, NADPH dehydrogenase (quinone) 
                EC 1.6.99.7                      dihydropteridine reductase. Now EC 1.5.1.34, 6,7-dihydropteridine reductase 
                EC 1.6.99.8                      aquacobalamin reductase. Now EC 1.16.1.3, aquacobalamin reductase 
                EC 1.6.99.9                      cob(II)alamin reductase. Now EC 1.16.1.4, cob(II)alamin reductase 
                EC 1.6.99.10                      dihydropteridine reductase (NADH). Now included with EC 1.5.1.34, 6,7-dihydropteridine reductase 
                EC 1.6.99.11                      aquacobalamin reductase (NADPH). Now EC 1.16.1.5, aquacobalamin reductase (NADPH) 
                EC 1.6.99.12                      cyanocobalamin reductase (NADPH, cyanide-eliminating). Now EC 1.16.1.6, cyanocobalamin reductase (cyanide-eliminating) 
                EC 1.6.99.13                      ferric-chelate reductase. Now EC 1.16.1.7, ferric-chelate reductase 
    EC 1.7  [+]      
        EC 1.7.1       []    With NAD+ or NADP+ as acceptor 
                EC 1.7.1.1                      nitrate reductase (NADH) 
                EC 1.7.1.2                      nitrate reductase [NAD(P)H] 
                EC 1.7.1.3                      nitrate reductase (NADPH) 
                EC 1.7.1.4                      nitrite reductase [NAD(P)H] 
                EC 1.7.1.5                      hyponitrite reductase 
                EC 1.7.1.6                      azobenzene reductase 
                EC 1.7.1.7                      GMP reductase 
                EC 1.7.1.8                       withdrawn in the light of further information on the acceptor 
                EC 1.7.1.9                      nitroquinoline-N-oxide reductase 
                EC 1.7.1.10                      hydroxylamine reductase (NADH) 
                EC 1.7.1.11                      4-(dimethylamino)phenylazoxybenzene reductase 
                EC 1.7.1.12                      N-hydroxy-2-acetamidofluorene reductase 
                EC 1.7.1.13                      preQ1 synthase 
                EC 1.7.1.14                      nitric oxide reductase [NAD(P)+, nitrous oxide-forming] 
                EC 1.7.1.15                      nitrite reductase (NADH) 
        EC 1.7.2       []    With a cytochrome as acceptor 
                EC 1.7.2.1                      nitrite reductase (NO-forming) 
                EC 1.7.2.2                      nitrite reductase (cytochrome; ammonia-forming) 
                EC 1.7.2.3                      trimethylamine-N-oxide reductase (cytochrome c) 
                EC 1.7.2.4                      nitrous-oxide reductase 
                EC 1.7.2.5                      nitric oxide reductase (cytochrome c) 
                EC 1.7.2.6                      hydroxylamine dehydrogenase 
                EC 1.7.2.7                      hydrazine synthase 
                EC 1.7.2.8                      hydrazine dehydrogenase 
        EC 1.7.3       []    With oxygen as acceptor 
                EC 1.7.3.1                      nitroalkane oxidase 
                EC 1.7.3.2                      acetylindoxyl oxidase 
                EC 1.7.3.3                      factor-independent urate hydroxylase 
                EC 1.7.3.4                      hydroxylamine oxidase. Now covered by EC 1.7.2.6, hydroxylamine dehydrogenase, and EC 1.7.3.6, hydroxylamine oxidase (cytochrome) 
                EC 1.7.3.5                      3-aci-nitropropanoate oxidase 
                EC 1.7.3.6                      hydroxylamine oxidase (cytochrome) 
        EC 1.7.5       []    With a quinone or similar compound as acceptor 
                EC 1.7.5.1                      nitrate reductase (quinone) 
                EC 1.7.5.2                      nitric oxide reductase (menaquinol) 
        EC 1.7.6       []    With a nitrogenous group as acceptor 
                EC 1.7.6.1                      nitrite dismutase 
        EC 1.7.7       []    With an iron-sulfur protein as acceptor 
                EC 1.7.7.1                      ferredoxin—nitrite reductase 
                EC 1.7.7.2                      ferredoxin—nitrate reductase 
        EC 1.7.9       []    With a copper protein as acceptor 
        EC 1.7.99       []    With unknown physiological acceptors 
                EC 1.7.99.1                      hydroxylamine reductase 
                EC 1.7.99.2                       nitric-oxide reductase. Reaction may have been due to the combined action of EC 1.7.99.6 nitrous-oxide reductase and EC 1.7.99.7 nitric-oxide reductase 
                EC 1.7.99.3                      nitrite reductase. Now included with EC 1.7.2.1, nitrite reductase (NO-forming) 
                EC 1.7.99.4                      nitrate reductase 
                EC 1.7.99.5                       5,10-methylenetetrahydrofolate reductase (FADH2). Now included with EC 1.5.1.20, methylenetetrahydrofolate reductase [NAD(P)H]. Based on the reference, it had been thought that this was a separate enzyme from EC 1.5.1.20 but the reference upon which the entry was based has since been disproved 
                EC 1.7.99.6                      EC 1.7.99.6, nitrous-oxide reductase. Now EC 1.7.2.4. 
                EC 1.7.99.7                      nitric-oxide reductase. Now EC 1.7.2.5 nitric oxide reductase (cytochrome c) 
                EC 1.7.99.8                      hydrazine oxidoreductase. Now classified as EC 1.7.2.8, hydrazine dehydrogenase. 
    EC 1.8  [+]      
        EC 1.8.1       []    With NAD+ or NADP+ as acceptor 
                EC 1.8.1.1                       cysteamine dehydrogenase 
                EC 1.8.1.2                      assimilatory sulfite reductase (NADPH) 
                EC 1.8.1.3                      hypotaurine dehydrogenase 
                EC 1.8.1.4                      dihydrolipoyl dehydrogenase 
                EC 1.8.1.5                      2-oxopropyl-CoM reductase (carboxylating) 
                EC 1.8.1.6                      cystine reductase 
                EC 1.8.1.7                      glutathione-disulfide reductase 
                EC 1.8.1.8                      protein-disulfide reductase 
                EC 1.8.1.9                      thioredoxin-disulfide reductase 
                EC 1.8.1.10                      CoA-glutathione reductase 
                EC 1.8.1.11                      asparagusate reductase 
                EC 1.8.1.12                      trypanothione-disulfide reductase 
                EC 1.8.1.13                      bis-γ-glutamylcystine reductase 
                EC 1.8.1.14                      CoA-disulfide reductase 
                EC 1.8.1.15                      mycothione reductase 
                EC 1.8.1.16                      glutathione amide reductase 
                EC 1.8.1.17                      dimethylsulfone reductase 
                EC 1.8.1.18                      NAD(P)H sulfur oxidoreductase (CoA-dependent) 
                EC 1.8.1.19                      sulfide dehydrogenase 
        EC 1.8.2       []    With a cytochrome as acceptor 
                EC 1.8.2.1                      sulfite dehydrogenase (cytochrome) 
                EC 1.8.2.2                      thiosulfate dehydrogenase 
                EC 1.8.2.3                      sulfide-cytochrome-c reductase (flavocytochrome c) 
                EC 1.8.2.4                      dimethyl sulfide:cytochrome c2 reductase 
                EC 1.8.2.5                      thiosulfate reductase (cytochrome) 
        EC 1.8.3       []    With oxygen as acceptor 
                EC 1.8.3.1                      sulfite oxidase 
                EC 1.8.3.2                      thiol oxidase 
                EC 1.8.3.3                      glutathione oxidase 
                EC 1.8.3.4                      methanethiol oxidase 
                EC 1.8.3.5                      prenylcysteine oxidase 
                EC 1.8.3.6                      farnesylcysteine lyase 
        EC 1.8.4       []    With a disulfide as acceptor 
                EC 1.8.4.1                      glutathione—homocystine transhydrogenase 
                EC 1.8.4.2                      protein-disulfide reductase (glutathione) 
                EC 1.8.4.3                      glutathione—CoA-glutathione transhydrogenase 
                EC 1.8.4.4                      glutathione—cystine transhydrogenase 
                EC 1.8.4.5                      methionine-S-oxide reductase. Now EC 1.8.4.13, L-methionine (S)-S-oxide reductase and EC 1.8.4.14, L-methionine (R)-S-oxide reductase 
                EC 1.8.4.6                      protein-methionine-S-oxide reductase. Proved to be due to EC 1.8.4.11, peptide-methionine (S)-S-oxide reductase 
                EC 1.8.4.7                      enzyme-thiol transhydrogenase (glutathione-disulfide) 
                EC 1.8.4.8                      phosphoadenylyl-sulfate reductase (thioredoxin) 
                EC 1.8.4.9                      adenylyl-sulfate reductase (glutathione) 
                EC 1.8.4.10                      adenylyl-sulfate reductase (thioredoxin) 
                EC 1.8.4.11                      peptide-methionine (S)-S-oxide reductase 
                EC 1.8.4.12                      peptide-methionine (R)-S-oxide reductase 
                EC 1.8.4.13                      L-methionine (S)-S-oxide reductase 
                EC 1.8.4.14                      L-methionine (R)-S-oxide reductase 
        EC 1.8.5       []    With a quinone or similar compound as acceptor 
                EC 1.8.5.1                      glutathione dehydrogenase (ascorbate) 
                EC 1.8.5.2                      thiosulfate dehydrogenase (quinone) 
                EC 1.8.5.3                      dimethylsulfoxide reductase 
                EC 1.8.5.4                      sulfide:quinone reductase 
                EC 1.8.5.5                      thiosulfate reductase (quinone) 
                EC 1.8.5.6                      sulfite dehydrogenase (quinone) 
                EC 1.8.5.7                      glutathionyl-hydroquinone reductase 
        EC 1.8.6       []    With a nitrogenous group as acceptor (deleted sub-subclass) 
                EC 1.8.6.1                       Nitrate-ester reductase. Now included with EC 2.5.1.18 glutathione transferase 
        EC 1.8.7       []    With an iron-sulfur protein as acceptor 
                EC 1.8.7.1                      assimilatory sulfite reductase (ferredoxin) 
                EC 1.8.7.2                      ferredoxin:thioredoxin reductase 
        EC 1.8.98       []    With other, known, physiological acceptors 
                EC 1.8.98.1                      CoB—CoM heterodisulfide reductase 
                EC 1.8.98.2                      sulfiredoxin 
                EC 1.8.98.3                      sulfite reductase (coenzyme F420) 
        EC 1.8.99       []    With unknown physiological acceptors 
                EC 1.8.99.1                      sulfite reductase. Now covered by EC 1.8.1.2, assimilatory sulfite reductase (NADPH) and EC 1.8.7.1, assimilatory sulfite reductase (ferredoxin).  
                EC 1.8.99.2                      adenylyl-sulfate reductase 
                EC 1.8.99.3                      hydrogensulfite reductase, now known to be an in vitro artifact of EC 1.8.99.5, dissimilatory sulfite reductase 
                EC 1.8.99.4                      phosphoadenosine-phosphosulfate reductase. Now EC 1.8.4.8, phosphoadenylyl-sulfate reductase (thioredoxin) 
                EC 1.8.99.5                      dissimilatory sulfite reductase 
    EC 1.9  [+]      
        EC 1.9.3       []    With oxygen as acceptor 
                EC 1.9.3.1                      cytochrome-c oxidase 
                EC 1.9.3.2                      Pseudomonas cytochrome oxidase. Now included with EC 1.7.2.1, nitrite reductase (NO-forming) 
        EC 1.9.6       []    With a nitrogenous group as acceptor 
                EC 1.9.6.1                      nitrate reductase (cytochrome) 
        EC 1.9.98       []    With other, known, physiological acceptors 
                EC 1.9.98.1                      iron—cytochrome-c reductase 
        EC 1.9.99       []    With unknown physiological acceptors 
                EC 1.9.99.1                      iron—cytochrome-c reductase. Now EC 1.9.98.1, iron—cytochrome-c reductase 
    EC 1.10  [+]      
        EC 1.10.1       []    With NAD+ or NADP+ as acceptor 
                EC 1.10.1.1                      trans-acenaphthene-1,2-diol dehydrogenase 
        EC 1.10.2       []    With a cytochrome as acceptor 
                EC 1.10.2.1                      L-ascorbate—cytochrome-b5 reductase 
                EC 1.10.2.2                      quinol—cytochrome-c reductase 
        EC 1.10.3       []    With oxygen as acceptor 
                EC 1.10.3.1                      catechol oxidase 
                EC 1.10.3.2                      laccase 
                EC 1.10.3.3                      L-ascorbate oxidase 
                EC 1.10.3.4                      o-aminophenol oxidase 
                EC 1.10.3.5                      3-hydroxyanthranilate oxidase 
                EC 1.10.3.6                      rifamycin-B oxidase 
                EC 1.10.3.7                      sulochrin oxidase [(+)-bisdechlorogeodin-forming]. Now EC 1.21.3.4, sulochrin oxidase [(+)-bisdechlorogeodin-forming] 
                EC 1.10.3.8                      sulochrin oxidase [(+)-bisdechlorogeodin-forming]. Now EC 1.21.3.5, sulochrin oxidase [(-)-bisdechlorogeodin-forming] 
                EC 1.10.3.9                      photosystem II 
                EC 1.10.3.10                      ubiquinol oxidase (H+-transporting) 
                EC 1.10.3.11                      ubiquinol oxidase (non-electrogenic) 
                EC 1.10.3.12                      menaquinol oxidase (H+-transporting) 
                EC 1.10.3.13                      caldariellaquinol oxidase (H+-transporting) 
                EC 1.10.3.14                      ubiquinol oxidase (electrogenic, non H+-transporting) 
                EC 1.10.3.15                      grixazone synthase 
                EC 1.10.3.16                      dihydrophenazinedicarboxylate synthase 
        EC 1.10.5       []    With a quinone or related compound as acceptor 
                EC 1.10.5.1                      ribosyldihydronicotinamide dehydrogenase (quinone) 
        EC 1.10.9       []    With a copper protein as acceptor 
                EC 1.10.9.1                      plastoquinol—plastocyanin reductase 
        EC 1.10.99       []    With unknown physiological acceptors 
                EC 1.10.99.1                      Now EC 1.10.9.1 plastoquinol—plastocyanin reductase 
                EC 1.10.99.2                      ribosyldihydronicotinamide dehydrogenase (quinone). Now classified as EC 1.10.5.1, ribosyldihydronicotinamide dehydrogenase (quinone). 
                EC 1.10.99.3                      violaxanthin de-epoxidase. Now classified as EC 1.23.5.1, violaxanthin de-epoxidase. 
    EC 1.11  [+]      
        EC 1.11.1       []      
                EC 1.11.1.1                      NADH peroxidase 
                EC 1.11.1.2                      NADPH peroxidase 
                EC 1.11.1.3                      fatty-acid peroxidase 
                EC 1.11.1.4                      now EC 1.13.11.11 tryptophan 2,3-dioxygenase 
                EC 1.11.1.5                      cytochrome-c peroxidase 
                EC 1.11.1.6                      catalase 
                EC 1.11.1.7                      peroxidase 
                EC 1.11.1.8                      iodide peroxidase 
                EC 1.11.1.9                      glutathione peroxidase 
                EC 1.11.1.10                      chloride peroxidase 
                EC 1.11.1.11                      L-ascorbate peroxidase 
                EC 1.11.1.12                      phospholipid-hydroperoxide glutathione peroxidase 
                EC 1.11.1.13                      manganese peroxidase 
                EC 1.11.1.14                      lignin peroxidase 
                EC 1.11.1.15                      peroxiredoxin 
                EC 1.11.1.16                      versatile peroxidase 
                EC 1.11.1.17                      glutathione amide-dependent peroxidase 
                EC 1.11.1.18                      bromide peroxidase 
                EC 1.11.1.19                      dye decolorizing peroxidase 
                EC 1.11.1.20                      prostamide/prostaglandin F synthase 
                EC 1.11.1.21                      catalase-peroxidase 
                EC 1.11.1.22                      hydroperoxy fatty acid reductase 
                EC 1.11.1.23                      (S)-2-hydroxypropylphosphonic acid epoxidase 
        EC 1.11.2       []      
                EC 1.11.2.1                      unspecific peroxygenase 
                EC 1.11.2.2                      myeloperoxidase 
                EC 1.11.2.3                      plant seed peroxygenase 
                EC 1.11.2.4                      fatty-acid peroxygenase 
                EC 1.11.2.5                      3-methyl-L-tyrosine peroxygenase 
    EC 1.12  [+]      
        EC 1.12.1       []    With NAD+ or NADP+ as acceptor 
                EC 1.12.1.1                      peroxidase. Now EC 1.12.7.2, ferredoxin hydrogenase 
                EC 1.12.1.2                      hydrogen dehydrogenase 
                EC 1.12.1.3                      hydrogen dehydrogenase (NADP+) 
                EC 1.12.1.4                      hydrogenase (NAD+, ferredoxin) 
                EC 1.12.1.5                      hydrogen dehydrogenase [NAD(P)+] 
        EC 1.12.2       []    With a cytochrome as acceptor 
                EC 1.12.2.1                      cytochrome-c3 hydrogenase 
        EC 1.12.5       []    With a quinone or similar compound as acceptor 
                EC 1.12.5.1                      hydrogen:quinone oxidoreductase 
        EC 1.12.7       []    With an iron-sulfur protein as acceptor 
                EC 1.12.7.1                      ferredoxin hydrogenase. Now EC 1.12.7.2, ferredoxin hydrogenase 
                EC 1.12.7.2                      ferredoxin hydrogenase 
        EC 1.12.98       []    With other, known, physiological acceptors 
                EC 1.12.98.1                      coenzyme F420 hydrogenase 
                EC 1.12.98.2                      5,10-methenyltetrahydromethanopterin hydrogenase 
                EC 1.12.98.3                      Methanosarcina-phenazine hydrogenase 
                EC 1.12.98.4                      sulfhydrogenase 
        EC 1.12.99       []    With unknown physiological acceptors 
                EC 1.12.99.1                      coenzyme F420 hydrogenase. Now EC 1.12.98.1, coenzyme F420 hydrogenase 
                EC 1.12.99.2                       coenzyme-M-7-mercaptoheptanoylthreonine-phosphate-heterodisulfide hydrogenase. Now shown to be two enzymes, EC 1.12.98.3, Methanosarcina-phenazine hydrogenase and EC 1.8.98.1, CoB—CoM heterodisulfide reductase 
                EC 1.12.99.3                      hydrogen:quinone oxidoreductase. Now EC 1.12.5.1, hydrogen:quinone oxidoreductase 
                EC 1.12.99.4                      N5,N10-methenyltetrahydromethanopterin hydrogenase. Now EC 1.12.98.2, 5,10-methenyltetrahydromethanopterin hydrogenase 
                EC 1.12.99.5                       3,4-dihydroxyquinoline 2,4-dioxygenase. Identical to EC 1.13.11.47, 3-hydroxy-4-oxoquinoline 2,4-dioxygenase 
                EC 1.12.99.6                      hydrogenase (acceptor) 
    EC 1.13  [+]      
        EC 1.13.11       []    With incorporation of two atoms of oxygen 
                EC 1.13.11.1                      catechol 1,2-dioxygenase 
                EC 1.13.11.2                      catechol 2,3-dioxygenase 
                EC 1.13.11.3                      protocatechuate 3,4-dioxygenase 
                EC 1.13.11.4                      gentisate 1,2-dioxygenase 
                EC 1.13.11.5                      homogentisate 1,2-dioxygenase 
                EC 1.13.11.6                      3-hydroxyanthranilate 3,4-dioxygenase 
                EC 1.13.11.7                       3,4-dihydroxyphenylacetate 3,4-dioxygenase 
                EC 1.13.11.8                      protocatechuate 4,5-dioxygenase 
                EC 1.13.11.9                      2,5-dihydroxypyridine 5,6-dioxygenase 
                EC 1.13.11.10                      7,8-dihydroxykynurenate 8,8a-dioxygenase 
                EC 1.13.11.11                      tryptophan 2,3-dioxygenase 
                EC 1.13.11.12                      linoleate 13S-lipoxygenase 
                EC 1.13.11.13                      ascorbate 2,3-dioxygenase. The activity is the sum of several enzymatic and spontaneous reactions 
                EC 1.13.11.14                      2,3-dihydroxybenzoate 3,4-dioxygenase 
                EC 1.13.11.15                      3,4-dihydroxyphenylacetate 2,3-dioxygenase 
                EC 1.13.11.16                      3-carboxyethylcatechol 2,3-dioxygenase 
                EC 1.13.11.17                      indole 2,3-dioxygenase 
                EC 1.13.11.18                      persulfide dioxygenase 
                EC 1.13.11.19                      cysteamine dioxygenase 
                EC 1.13.11.20                      cysteine dioxygenase 
                EC 1.13.11.21                      β-carotene 15,15′-dioxygenase. Now EC 1.14.99.36, β-carotene 15,15′-monooxygenase 
                EC 1.13.11.22                      caffeate 3,4-dioxygenase 
                EC 1.13.11.23                      2,3-dihydroxyindole 2,3-dioxygenase 
                EC 1.13.11.24                      quercetin 2,3-dioxygenase 
                EC 1.13.11.25                      3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione 4,5-dioxygenase 
                EC 1.13.11.26                      peptide-tryptophan 2,3-dioxygenase 
                EC 1.13.11.27                      4-hydroxyphenylpyruvate dioxygenase 
                EC 1.13.11.28                      2,3-dihydroxybenzoate 2,3-dioxygenase 
                EC 1.13.11.29                      stizolobate synthase 
                EC 1.13.11.30                      stizolobinate synthase 
                EC 1.13.11.31                      arachidonate 12-lipoxygenase 
                EC 1.13.11.32                      2-nitropropane dioxygenase. Now EC 1.13.12.16, nitronate monooxygenase 
                EC 1.13.11.33                      arachidonate 15-lipoxygenase 
                EC 1.13.11.34                      arachidonate 5-lipoxygenase 
                EC 1.13.11.35                      pyrogallol 1,2-oxygenase 
                EC 1.13.11.36                      chloridazon-catechol dioxygenase 
                EC 1.13.11.37                      hydroxyquinol 1,2-dioxygenase 
                EC 1.13.11.38                      1-hydroxy-2-naphthoate 1,2-dioxygenase 
                EC 1.13.11.39                      biphenyl-2,3-diol 1,2-dioxygenase 
                EC 1.13.11.40                      arachidonate 8-lipoxygenase 
                EC 1.13.11.41                      2,4′-dihydroxyacetophenone dioxygenase 
                EC 1.13.11.42                       indoleamine-pyrrole 2,3-dioxygenase. The enzyme was identical to EC 1.13.11.11, tryptophan 2,3-dioxygenase 
                EC 1.13.11.43                      lignostilbene αβ-dioxygenase 
                EC 1.13.11.44                      linoleate diol synthase. Activity is covered by EC 1.13.11.60, linoleate 8R-lipoxygenase and EC 5.4.4.6, 9,12-octadecadienoate 8-hydroperoxide 8S-isomerase. 
                EC 1.13.11.45                      linoleate 11-lipoxygenase 
                EC 1.13.11.46                      4-hydroxymandelate synthase 
                EC 1.13.11.47                      3-hydroxy-4-oxoquinoline 2,4-dioxygenase 
                EC 1.13.11.48                      3-hydroxy-2-methylquinolin-4-one 2,4-dioxygenase 
                EC 1.13.11.49                      chlorite O2-lyase 
                EC 1.13.11.50                      acetylacetone-cleaving enzyme 
                EC 1.13.11.51                      9-cis-epoxycarotenoid dioxygenase 
                EC 1.13.11.52                      indoleamine 2,3-dioxygenase 
                EC 1.13.11.53                      acireductone dioxygenase (Ni2+-requiring) 
                EC 1.13.11.54                      acireductone dioxygenase [iron(II)-requiring] 
                EC 1.13.11.55                      sulfur oxygenase/reductase 
                EC 1.13.11.56                      1,2-dihydroxynaphthalene dioxygenase 
                EC 1.13.11.57                      gallate dioxygenase 
                EC 1.13.11.58                      linoleate 9S-lipoxygenase 
                EC 1.13.11.59                      torulene dioxygenase 
                EC 1.13.11.60                      linoleate 8R-lipoxygenase 
                EC 1.13.11.61                      linolenate 9R-lipoxygenase 
                EC 1.13.11.62                      linoleate 10R-lipoxygenase 
                EC 1.13.11.63                      β-carotene 15,15′-dioxygenase 
                EC 1.13.11.64                      5-nitrosalicylate dioxygenase 
                EC 1.13.11.65                      carotenoid isomerooxygenase 
                EC 1.13.11.66                      hydroquinone 1,2-dioxygenase 
                EC 1.13.11.67                      8′-apo-β-carotenoid 14′,13′-cleaving dioxygenase 
                EC 1.13.11.68                      9-cis-β-carotene 9′,10′-cleaving dioxygenase 
                EC 1.13.11.69                      carlactone synthase 
                EC 1.13.11.70                      all-trans-10′-apo-β-carotenal 13,14-cleaving dioxygenase 
                EC 1.13.11.71                      carotenoid-9′,10′-cleaving dioxygenase 
                EC 1.13.11.72                      2-hydroxyethylphosphonate dioxygenase 
                EC 1.13.11.73                      methylphosphonate synthase 
                EC 1.13.11.74                      2-aminophenol 1,6-dioxygenase 
                EC 1.13.11.75                      all-trans-8′-apo-β-carotenal 15,15′-oxygenase 
                EC 1.13.11.76                      2-amino-5-chlorophenol 1,6-dioxygenase 
                EC 1.13.11.77                      oleate 10S-lipoxygenase 
                EC 1.13.11.78                      2-amino-1-hydroxyethylphosphonate dioxygenase (glycine-forming) 
                EC 1.13.11.79                      5,6-dimethylbenzimidazole synthase 
                EC 1.13.11.80                      (3,5-dihydroxyphenyl)acetyl-CoA 1,2-dioxygenase 
                EC 1.13.11.81                      7,8-dihydroneopterin oxygenase 
                EC 1.13.11.82                      8′-apo-carotenoid 13,14-cleaving dioxygenase 
        EC 1.13.12       []    With incorporation of one atom of oxygen (internal monooxygenases or internal mixed-function oxidases) 
                EC 1.13.12.1                      arginine 2-monooxygenase 
                EC 1.13.12.2                      lysine 2-monooxygenase 
                EC 1.13.12.3                      tryptophan 2-monooxygenase 
                EC 1.13.12.4                      lactate 2-monooxygenase 
                EC 1.13.12.5                      Renilla-luciferin 2-monooxygenase 
                EC 1.13.12.6                      Cypridina-luciferin 2-monooxygenase 
                EC 1.13.12.7                      Photinus-luciferin 4-monooxygenase (ATP-hydrolysing) 
                EC 1.13.12.8                      Watasenia-luciferin 2-monooxygenase 
                EC 1.13.12.9                      phenylalanine 2-monooxygenase 
                EC 1.13.12.10                       lysine 6-monooxygenase. Reaction covered by EC 1.14.13.59, L-lysine 6-monooxygenase (NADPH) 
                EC 1.13.12.11                      methylphenyltetrahydropyridine N-monooxygenase. The activity is due to EC 1.14.13.8, flavin-containing monooxygenase 
                EC 1.13.12.12                      apo-β-carotenoid-14′,13′-dioxygenase. The enzyme was misclassified and has been transferred to EC 1.13.11.67, 8-apo-β-carotenoid 14′,13′-cleaving dioxygenase 
                EC 1.13.12.13                      Oplophorus-luciferin 2-monooxygenase 
                EC 1.13.12.14                      chlorophyllide-a oxygenase. Now EC 1.14.13.122, chlorophyllide-a oxygenase 
                EC 1.13.12.15                      3,4-dihydroxyphenylalanine oxidative deaminase 
                EC 1.13.12.16                      nitronate monooxygenase 
                EC 1.13.12.17                      dichloroarcyriaflavin A synthase 
                EC 1.13.12.18                      dinoflagellate luciferase 
                EC 1.13.12.19                      2-oxoglutarate dioxygenase (ethylene-forming) 
                EC 1.13.12.20                      noranthrone monooxygenase 
                EC 1.13.12.21                      tetracenomycin-F1 monooxygenase 
                EC 1.13.12.22                      deoxynogalonate monooxygenase 
        EC 1.13.99       []    Miscellaneous 
                EC 1.13.99.1                      inositol oxygenase 
                EC 1.13.99.2                      benzoate 1,2-dioxygenase. Now EC 1.14.12.10, benzoate 1,2-dioxygenase 
                EC 1.13.99.3                      tryptophan 2′-dioxygenase 
                EC 1.13.99.4                      4-chlorophenylacetate 3,4-dioxygenase. Now EC 1.14.12.9, 4-chlorophenylacetate 3,4-dioxygenase 
                EC 1.13.99.5                      now EC 1.13.11.47, 3-hydroxy-4-oxoquinoline 2,4-dioxygenase 
    EC 1.14  [+]      
        EC 1.14.1       []    With NADH or NADPH as one donor (deleted sub-subclass) 
                EC 1.14.1.1                      now EC 1.14.14.1, unspecific monooxygenase 
                EC 1.14.1.2                      now EC 1.14.13.9, kynurenine 3-monooxygenase 
                EC 1.14.1.3                      squalene hydroxylase. Activity is covered by EC 1.14.99.7, squalene monooxygenase and EC 5.4.99.7, lanosterol synthase 
                EC 1.14.1.4                      now EC 1.14.99.2, kynurenine 7,8-hydroxylase 
                EC 1.14.1.5                      now EC 1.14.13.5, imidazoleacetate 4-monooxygenase 
                EC 1.14.1.6                      now EC 1.14.15.4, steroid 11β-monooxygenase 
                EC 1.14.1.7                      now EC 1.14.99.9, steroid 17α-monooxygenase 
                EC 1.14.1.8                      now EC 1.14.99.10, steroid 21-monooxygenase 
                EC 1.14.1.9                       cholesterol 20-hydroxylase 
                EC 1.14.1.10                      now EC 1.14.99.11, estradiol 6β-monooxygenase 
                EC 1.14.1.11                      oestriol 2-hydroxylase 
        EC 1.14.2       []    With ascorbate as one donor (deleted sub-subclass) 
                EC 1.14.2.1                      now EC 1.14.17.1, dopamine β-monooxygenase 
                EC 1.14.2.2                      now EC 1.13.11.27, 4-hydroxyphenylpyruvate dioxygenase 
        EC 1.14.3       []    With reduced pteridine as one donor (deleted sub-subclass) 
                EC 1.14.3.1                      now EC 1.14.16.1, phenylalanine 4-monooxygenase 
        EC 1.14.11       []    With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor 
                EC 1.14.11.1                      γ-butyrobetaine dioxygenase 
                EC 1.14.11.2                      procollagen-proline dioxygenase 
                EC 1.14.11.3                      pyrimidine-deoxynucleoside 2′-dioxygenase 
                EC 1.14.11.4                      procollagen-lysine 5-dioxygenase 
                EC 1.14.11.5                       5-hydroxymethyluracil,2-oxoglutarate dioxygenase. Now included with EC 1.14.11.6 thymine dioxygenase 
                EC 1.14.11.6                      thymine dioxygenase 
                EC 1.14.11.7                      procollagen-proline 3-dioxygenase 
                EC 1.14.11.8                      trimethyllysine dioxygenase 
                EC 1.14.11.9                      flavanone 3-dioxygenase 
                EC 1.14.11.10                      pyrimidine-deoxynucleoside 1′-dioxygenase 
                EC 1.14.11.11                      hyoscyamine (6S)-dioxygenase 
                EC 1.14.11.12                      gibberellin-44 dioxygenase 
                EC 1.14.11.13                      gibberellin 2β-dioxygenase 
                EC 1.14.11.14                      6β-hydroxyhyoscyamine epoxidase 
                EC 1.14.11.15                      gibberellin 3β-dioxygenase 
                EC 1.14.11.16                      peptide-aspartate β-dioxygenase 
                EC 1.14.11.17                      taurine dioxygenase 
                EC 1.14.11.18                      phytanoyl-CoA dioxygenase 
                EC 1.14.11.19                      anthocyanidin synthase 
                EC 1.14.11.20                      deacetoxyvindoline 4-hydroxylase 
                EC 1.14.11.21                      clavaminate synthase 
                EC 1.14.11.22                      flavone synthase 
                EC 1.14.11.23                      flavonol synthase 
                EC 1.14.11.24                      2′-deoxymugineic-acid 2′-dioxygenase 
                EC 1.14.11.25                      mugineic-acid 3-dioxygenase 
                EC 1.14.11.26                      deacetoxycephalosporin-C hydroxylase 
                EC 1.14.11.27                      [histone-H3]-lysine-36 demethylase 
                EC 1.14.11.28                      proline 3-hydroxylase 
                EC 1.14.11.29                      hypoxia-inducible factor-proline dioxygenase 
                EC 1.14.11.30                      hypoxia-inducible factor-asparagine dioxygenase 
                EC 1.14.11.31                      thebaine 6-O-demethylase 
                EC 1.14.11.32                      codeine 3-O-demethylase 
                EC 1.14.11.33                      DNA oxidative demethylase 
                EC 1.14.11.34                      2-oxoglutarate/L-arginine monooxygenase/decarboxylase (succinate-forming) 
                EC 1.14.11.35                      1-deoxypentalenic acid 11β-hydroxylase 
                EC 1.14.11.36                      pentalenolactone F synthase 
                EC 1.14.11.37                      kanamycin B dioxygenase 
                EC 1.14.11.38                      verruculogen synthase 
                EC 1.14.11.39                      L-asparagine hydroxylase 
                EC 1.14.11.40                      enduracididine β-hydroxylase 
                EC 1.14.11.41                      L-arginine hydroxylase 
                EC 1.14.11.42                      tRNAPhe (7-(3-amino-3-carboxypropyl)wyosine37-C2)-hydroxylase  
                EC 1.14.11.43                      (S)-dichlorprop dioxygenase (2-oxoglutarate) 
                EC 1.14.11.44                      (R)-dichlorprop dioxygenase (2-oxoglutarate) 
                EC 1.14.11.45                      L-isoleucine 4-hydroxylase 
                EC 1.14.11.46                      2-aminoethylphosphonate dioxygenase 
                EC 1.14.11.47                      50S ribosomal protein L16 3-hydroxylase 
                EC 1.14.11.48                      xanthine dioxygenase 
                EC 1.14.11.49                      uridine-5′-phosphate dioxygenase 
                EC 1.14.11.50                      (–)-deoxypodophyllotoxin synthase 
                EC 1.14.11.51                      DNA N6-methyladenine demethylase 
                EC 1.14.11.52                      validamycin A dioxygenase 
                EC 1.14.11.53                      mRNA N6-methyladenine demethylase 
                EC 1.14.11.54                      mRNA N1-methyladenine demethylase 
                EC 1.14.11.55                      ectoine hydroxylase 
                EC 1.14.11.56                      L-proline cis-4-hydroxylase 
                EC 1.14.11.57                      L-proline trans-4-hydroxylase 
        EC 1.14.12       []    With NADH or NADPH as one donor, and incorporation of two atoms of oxygen into the other donor 
                EC 1.14.12.1                      anthranilate 1,2-dioxygenase (deaminating, decarboxylating) 
                EC 1.14.12.2                      now EC 1.14.13.35 anthranilate 3-monooxygenase (deaminating) 
                EC 1.14.12.3                      benzene 1,2-dioxygenase 
                EC 1.14.12.4                      3-hydroxy-2-methylpyridinecarboxylate dioxygenase 
                EC 1.14.12.5                      5-pyridoxate dioxygenase 
                EC 1.14.12.6                      2-hydroxycyclohexanone 2-monooxygenase. Now EC 1.14.13.66, 2-hydroxycyclohexanone 2-monooxygenase 
                EC 1.14.12.7                      phthalate 4,5-dioxygenase 
                EC 1.14.12.8                      4-sulfobenzoate 3,4-dioxygenase 
                EC 1.14.12.9                      4-chlorophenylacetate 3,4-dioxygenase 
                EC 1.14.12.10                      benzoate 1,2-dioxygenase 
                EC 1.14.12.11                      toluene dioxygenase 
                EC 1.14.12.12                      naphthalene 1,2-dioxygenase 
                EC 1.14.12.13                      2-halobenzoate 1,2-dioxygenase 
                EC 1.14.12.14                      2-aminobenzenesulfonate 2,3-dioxygenase 
                EC 1.14.12.15                      terephthalate 1,2-dioxygenase 
                EC 1.14.12.16                      2-hydroxyquinoline 5,6-dioxygenase 
                EC 1.14.12.17                      nitric oxide dioxygenase 
                EC 1.14.12.18                      biphenyl 2,3-dioxygenase 
                EC 1.14.12.19                      3-phenylpropanoate dioxygenase 
                EC 1.14.12.20                      pheophorbide a oxygenase. Now classified as EC 1.14.15.17, pheophorbide a oxygenase. 
                EC 1.14.12.21                      benzoyl-CoA 2,3-dioxygenase. Now EC 1.14.13.208, benzoyl-CoA 2,3-epoxidase 
                EC 1.14.12.22                      carbazole 1,9a-dioxygenase 
                EC 1.14.12.23                      nitroarene dioxygenase 
                EC 1.14.12.24                      2,4-dinitrotoluene dioxygenase 
                EC 1.14.12.25                      p-cumate 2,3-dioxygenase 
        EC 1.14.13       []    With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor 
                EC 1.14.13.1                      salicylate 1-monooxygenase 
                EC 1.14.13.2                      4-hydroxybenzoate 3-monooxygenase 
                EC 1.14.13.3                      4-hydroxyphenylacetate 3-monooxygenase. Now EC 1.14.14.9, 4-hydroxyphenylacetate 3-monooxygenase. 
                EC 1.14.13.4                      melilotate 3-monooxygenase 
                EC 1.14.13.5                      imidazoleacetate 4-monooxygenase 
                EC 1.14.13.6                      orcinol 2-monooxygenase 
                EC 1.14.13.7                      phenol 2-monooxygenase (NADPH) 
                EC 1.14.13.8                      flavin-containing monooxygenase 
                EC 1.14.13.9                      kynurenine 3-monooxygenase 
                EC 1.14.13.10                      2,6-dihydroxypyridine 3-monooxygenase 
                EC 1.14.13.11                      trans-cinnamate 4-monooxygenase 
                EC 1.14.13.12                      benzoate 4-monooxygenase 
                EC 1.14.13.13                      calcidiol 1-monooxygenase. Now classified as EC 1.14.15.18, calcidiol 1-monooxygenase 
                EC 1.14.13.14                      trans-cinnamate 2-monooxygenase 
                EC 1.14.13.15                      cholestanetriol 26-monooxygenase. Now EC 1.14.15.15, cholestanetriol 26-monooxygenase. 
                EC 1.14.13.16                      cyclopentanone monooxygenase 
                EC 1.14.13.17                      cholesterol 7α-monooxygenase. Now EC 1.14.14.23, cholesterol 7α-monooxygenase 
                EC 1.14.13.18                      4-hydroxyphenylacetate 1-monooxygenase 
                EC 1.14.13.19                      taxifolin 8-monooxygenase 
                EC 1.14.13.20                      2,4-dichlorophenol 6-monooxygenase 
                EC 1.14.13.21                      flavonoid 3′-monooxygenase 
                EC 1.14.13.22                      cyclohexanone monooxygenase 
                EC 1.14.13.23                      3-hydroxybenzoate 4-monooxygenase 
                EC 1.14.13.24                      3-hydroxybenzoate 6-monooxygenase 
                EC 1.14.13.25                      methane monooxygenase (soluble) 
                EC 1.14.13.26                      phosphatidylcholine 12-monooxygenase. Now classified as EC 1.14.18.4, phosphatidylcholine 12-monooxygenase. 
                EC 1.14.13.27                      4-aminobenzoate 1-monooxygenase 
                EC 1.14.13.28                      3,9-dihydroxypterocarpan 6a-monooxygenase 
                EC 1.14.13.29                      4-nitrophenol 2-monooxygenase 
                EC 1.14.13.30                      leukotriene-B4 20-monooxygenase 
                EC 1.14.13.31                      2-nitrophenol 2-monooxygenase 
                EC 1.14.13.32                      albendazole monooxygenase 
                EC 1.14.13.33                      4-hydroxybenzoate 3-monooxygenase [NAD(P)H] 
                EC 1.14.13.34                      leukotriene-E4 20-monooxygenase 
                EC 1.14.13.35                      anthranilate 3-monooxygenase (deaminating) 
                EC 1.14.13.36                      5-O-(4-coumaroyl)-D-quinate 3′-monooxygenase 
                EC 1.14.13.37                      methyltetrahydroprotoberberine 14-monooxygenase 
                EC 1.14.13.38                      anhydrotetracycline 6-monooxygenase 
                EC 1.14.13.39                      nitric-oxide synthase (NADPH) 
                EC 1.14.13.40                      anthraniloyl-CoA monooxygenase 
                EC 1.14.13.41                      tyrosine N-monooxygenase. Now EC 1.14.14.36, tyrosine N-monooxygenase 
                EC 1.14.13.42                      hydroxyphenylacetonitrile 2-monooxygenase. The activity is covered by EC 1.14.13.68, 4-hydroxyphenylacetaldehyde oxime monooxygenase, that performs the two consecutive reactions in the conversion of (Z)-4-hydroxyphenylacetaldehyde oxime to (S)-4-hydroxymandelonitrile 
                EC 1.14.13.43                      questin monooxygenase 
                EC 1.14.13.44                      2-hydroxybiphenyl 3-monooxygenase 
                EC 1.14.13.45                      CMP-N-acetylneuraminate monooxygenase. Now EC 1.14.18.2, CMP-N-acetylneuraminate monooxygenase 
                EC 1.14.13.46                      (-)-menthol monooxygenase 
                EC 1.14.13.47                      (S)-limonene 3-monooxygenase 
                EC 1.14.13.48                      (S)-limonene 6-monooxygenase 
                EC 1.14.13.49                      (S)-limonene 7-monooxygenase 
                EC 1.14.13.50                      pentachlorophenol monooxygenase 
                EC 1.14.13.51                      6-oxocineole dehydrogenase 
                EC 1.14.13.52                      isoflavone 3′-hydroxylase 
                EC 1.14.13.53                      4′-methoxyisoflavone 2′-hydroxylase 
                EC 1.14.13.54                      ketosteroid monooxygenase 
                EC 1.14.13.55                      protopine 6-monooxygenase 
                EC 1.14.13.56                      dihydrosanguinarine 10-monooxygenase 
                EC 1.14.13.57                      dihydrochelirubine 12-monooxygenase 
                EC 1.14.13.58                      benzoyl-CoA 3-monooxygenase 
                EC 1.14.13.59                      L-lysine N6-monooxygenase (NADPH) 
                EC 1.14.13.60                      27-hydroxycholesterol 7α-monooxygenase. Now included with EC 1.14.13.100, 25-hydroxycholesterol 7α-hydroxylase 
                EC 1.14.13.61                      2-hydroxyquinoline 8-monooxygenase 
                EC 1.14.13.62                      4-hydroxyquinoline 3-monooxygenase 
                EC 1.14.13.63                      3-hydroxyphenylacetate 6-hydroxylase 
                EC 1.14.13.64                      4-hydroxybenzoate 1-hydroxylase 
                EC 1.14.13.65                       2-hydroxyquinoline 8-monooxygenase 
                EC 1.14.13.66                      2-hydroxycyclohexanone 2-monooxygenase 
                EC 1.14.13.67                      quinine 3-monooxygenase 
                EC 1.14.13.68                      4-hydroxyphenylacetaldehyde oxime monooxygenase. Now EC 1.14.14.37, 4-hydroxyphenylacetaldehyde oxime monooxygenase 
                EC 1.14.13.69                      alkene monooxygenase 
                EC 1.14.13.70                      sterol 14α-demethylase 
                EC 1.14.13.71                      N-methylcoclaurine 3′-monooxygenase 
                EC 1.14.13.72                      methylsterol monooxygenase 
                EC 1.14.13.73                      tabersonine 16-hydroxylase 
                EC 1.14.13.74                      7-deoxyloganin 7-hydroxylase 
                EC 1.14.13.75                      vinorine hydroxylase 
                EC 1.14.13.76                      taxane 10β-hydroxylase 
                EC 1.14.13.77                      taxane 13α-hydroxylase 
                EC 1.14.13.78                      ent-kaurene oxidase 
                EC 1.14.13.79                      ent-kaurenoic acid oxidase 
                EC 1.14.13.80                      (R)-limonene 6-monooxygenase 
                EC 1.14.13.81                      magnesium-protoporphyrin IX monomethyl ester (oxidative) cyclase 
                EC 1.14.13.82                      vanillate monooxygenase 
                EC 1.14.13.83                      precorrin-3B synthase 
                EC 1.14.13.84                      4-hydroxyacetophenone monooxygenase 
                EC 1.14.13.85                      glyceollin synthase 
                EC 1.14.13.86                      2-hydroxyisoflavanone synthase. This enzyme was classified on the basis of an incorrect reaction. The activity is covered by EC 1.14.13.136, 2-hydroxyisoflavanone synthase 
                EC 1.14.13.87                      licodione synthase 
                EC 1.14.13.88                      flavanoid 3′,5′-hydroxylase 
                EC 1.14.13.89                      isoflavone 2′-hydroxylase 
                EC 1.14.13.90                      zeaxanthin epoxidase. Now EC 1.14.15.21, zeaxanthin epoxidase 
                EC 1.14.13.91                      deoxysarpagine hydroxylase 
                EC 1.14.13.92                      phenylacetone monooxygenase 
                EC 1.14.13.93                      (+)-abscisic acid 8′-hydroxylase 
                EC 1.14.13.94                      lithocholate 6β-hydroxylase 
                EC 1.14.13.95                      7α-hydroxycholest-4-en-3-one 12α-hydroxylase. Now EC 1.14.18.8, 7α-hydroxycholest-4-en-3-one 12α-hydroxylase 
                EC 1.14.13.96                      5β-cholestane-3α,7α-diol 12α-hydroxylase 
                EC 1.14.13.97                      taurochenodeoxycholate 6α-hydroxylase 
                EC 1.14.13.98                      cholesterol 24-hydroxylase. Now EC 1.14.14.25, cholesterol 24-hydroxylase  
                EC 1.14.13.99                      24-hydroxycholesterol 7α-hydroxylase. Now EC 1.14.14.26, 24-hydroxycholesterol 7α-hydroxylase 
                EC 1.14.13.100                      25/26-hydroxycholesterol 7α-hydroxylase. Now classified as EC 1.14.14.29, 25/26-hydroxycholesterol 7α-hydroxylase 
                EC 1.14.13.101                      senecionine N-oxygenase 
                EC 1.14.13.102                      psoralen synthase 
                EC 1.14.13.103                      8-dimethylallylnaringenin 2′-hydroxylase 
                EC 1.14.13.104                      (+)-menthofuran synthase 
                EC 1.14.13.105                      monocyclic monoterpene ketone monooxygenase 
                EC 1.14.13.106                      epi-isozizaene 5-monooxygenase 
                EC 1.14.13.107                      limonene 1,2-monooxygenase 
                EC 1.14.13.108                      abieta-7,13-diene hydroxylase 
                EC 1.14.13.109                      abieta-7,13-dien-18-ol hydroxylase 
                EC 1.14.13.110                      geranylgeraniol 18-hydroxylase 
                EC 1.14.13.111                      methanesulfonate monooxygenase (NADH) 
                EC 1.14.13.112                      3-epi-6-deoxocathasterone 23-monooxygenase 
                EC 1.14.13.113                      FAD-dependent urate hydroxylase 
                EC 1.14.13.114                      6-hydroxynicotinate 3-monooxygenase 
                EC 1.14.13.115                      angelicin synthase 
                EC 1.14.13.116                      geranylhydroquinone 3′′-hydroxylase 
                EC 1.14.13.117                      isoleucine N-monooxygenase, Now EC 1.14.14.39, isoleucine N-monooxygenase 
                EC 1.14.13.118                      valine N-monooxygenase. Now EC 1.14.14.38, valine N-monooxygenase 
                EC 1.14.13.119                      5-epiaristolochene 1,3-dihydroxylase 
                EC 1.14.13.120                      costunolide synthase 
                EC 1.14.13.121                      premnaspirodiene oxygenase 
                EC 1.14.13.122                      chlorophyllide-a oxygenase 
                EC 1.14.13.123                      germacrene A hydroxylase 
                EC 1.14.13.124                      phenylalanine N-monooxygenase, now classified as EC 1.14.14.40, phenylalanine N-monooxygenase 
                EC 1.14.13.125                      tryptophan N-monooxygenase 
                EC 1.14.13.126                      vitamin D3 24-hydroxylase. Now EC 1.14.15.16, vitamin D3 24-hydroxylase 
                EC 1.14.13.127                      3-(3-hydroxyphenyl)propanoate hydroxylase 
                EC 1.14.13.128                      7-methylxanthine demethylase 
                EC 1.14.13.129                      β-carotene 3-hydroxylase 
                EC 1.14.13.130                      pyrrole-2-carboxylate monooxygenase 
                EC 1.14.13.131                      dimethyl-sulfide monooxygenase 
                EC 1.14.13.132                      squalene monooxygenase. Now EC 1.14.14.17, squalene monooxygenase 
                EC 1.14.13.133                      pentalenene oxygenase 
                EC 1.14.13.134                      β-amyrin 11-oxidase 
                EC 1.14.13.135                      1-hydroxy-2-naphthoate hydroxylase 
                EC 1.14.13.136                      2-hydroxyisoflavanone synthase 
                EC 1.14.13.137                      indole-2-monooxygenase 
                EC 1.14.13.138                      indolin-2-one monooxygenase 
                EC 1.14.13.139                      3-hydroxyindolin-2-one monooxygenase 
                EC 1.14.13.140                      2-hydroxy-1,4-benzoxazin-3-one monooxygenase 
                EC 1.14.13.141                      cholest-4-en-3-one 26-monooxygenase [(25S)-3-oxocholest-4-en-26-oate forming] 
                EC 1.14.13.142                      3-ketosteroid 9α-monooxygenase 
                EC 1.14.13.143                      ent-isokaurene C2-hydroxylase 
                EC 1.14.13.144                      9β-pimara-7,15-diene oxidase 
                EC 1.14.13.145                      ent-cassa-12,15-diene 11-hydroxylase 
                EC 1.14.13.146                      taxoid 14β-hydroxylase 
                EC 1.14.13.147                      taxoid 7β-hydroxylase 
                EC 1.14.13.148                      trimethylamine monooxygenase 
                EC 1.14.13.149                      phenylacetyl-CoA 1,2-epoxidase 
                EC 1.14.13.150                      α-humulene 10-hydroxylase 
                EC 1.14.13.151                      linalool 8-monooxygenase 
                EC 1.14.13.152                      geraniol 8-hydroxylase 
                EC 1.14.13.153                      (+)-sabinene 3-hydroxylase 
                EC 1.14.13.154                      erythromycin 12-hydroxylase 
                EC 1.14.13.155                      α-pinene monooxygenase 
                EC 1.14.13.156                      1,8-cineole 2-endo-monooxygenase 
                EC 1.14.13.157                      1,8-cineole 2-exo-monooxygenase 
                EC 1.14.13.158                      amorpha-4,11-diene 12-monooxygenase 
                EC 1.14.13.159                      vitamin D 25-hydroxylase. Now EC 1.14.14.24, vitamin D 25-hydroxylase 
                EC 1.14.13.160                      (2,2,3-trimethyl-5-oxocyclopent-3-enyl)acetyl-CoA 1,5-monooxygenase 
                EC 1.14.13.161                      (+)-camphor 6-exo-hydroxylase 
                EC 1.14.13.162                      2,5-diketocamphane 1,2-monooxygenase 
                EC 1.14.13.163                      6-hydroxy-3-succinoylpyridine 3-monooxygenase 
                EC 1.14.13.164                      carotenoid isomerooxygenase. The enzyme was discovered at the public-review stage to have been misclassified and so was withdrawn. See EC 1.13.11.65, carotenoid isomerooxygenase 
                EC 1.14.13.165                      nitric-oxide synthase [NAD(P)H] 
                EC 1.14.13.166                      4-nitrocatechol 4-monooxygenase 
                EC 1.14.13.167                      4-nitrophenol 4-monooxygenase 
                EC 1.14.13.168                      indole-3-pyruvate monooxygenase 
                EC 1.14.13.169                      sphinganine C4-monooxygenase. Now EC 1.14.18.5, sphingolipid C4-monooxygenase 
                EC 1.14.13.170                      pentalenolactone D synthase 
                EC 1.14.13.171                      neopentalenolactone D synthase 
                EC 1.14.13.172                      salicylate 5-hydroxylase 
                EC 1.14.13.173                      11-oxo-β-amyrin 30-oxidase 
                EC 1.14.13.174                      averantin hydroxylase 
                EC 1.14.13.175                      aflatoxin B synthase 
                EC 1.14.13.176                      tryprostatin B 6-hydroxylase 
                EC 1.14.13.177                      fumitremorgin C monooxygenase 
                EC 1.14.13.178                      methylxanthine N1-demethylase 
                EC 1.14.13.179                      methylxanthine N3-demethylase 
                EC 1.14.13.180                      aklavinone 12-hydroxylase 
                EC 1.14.13.181                      13-deoxydaunorubicin hydroxylase 
                EC 1.14.13.182                      2-heptyl-3-hydroxy-4(1H)-quinolone synthase 
                EC 1.14.13.183                      dammarenediol 12-hydroxylase 
                EC 1.14.13.184                      protopanaxadiol 6-hydroxylase 
                EC 1.14.13.185                      pikromycin synthase 
                EC 1.14.13.186                      20-oxo-5-O-mycaminosyltylactone 23-monooxygenase 
                EC 1.14.13.187                      L-evernosamine nitrososynthase 
                EC 1.14.13.188                      6-deoxyerythronolide B hydroxylase 
                EC 1.14.13.189                      5-methyl-1-naphthoate 3-hydroxylase 
                EC 1.14.13.190                      ferruginol synthase 
                EC 1.14.13.191                      ent-sandaracopimaradiene 3-hydroxylase 
                EC 1.14.13.192                      oryzalexin E synthase 
                EC 1.14.13.193                      oryzalexin D synthase 
                EC 1.14.13.194                      phylloquinone ω-hydroxylase 
                EC 1.14.13.195                      L-ornithine N5-monooxygenase (NADPH) 
                EC 1.14.13.196                      L-ornithine N5-monooxygenase [NAD(P)H] 
                EC 1.14.13.197                      dihydromonacolin L hydroxylase 
                EC 1.14.13.198                      monacolin L hydroxylase 
                EC 1.14.13.199                      docosahexaenoic acid ω-hydroxylase 
                EC 1.14.13.200                      tetracenomycin A2 monooxygenase-dioxygenase 
                EC 1.14.13.201                      β-amyrin 28-monooxygenase 
                EC 1.14.13.202                      methyl farnesoate epoxidase 
                EC 1.14.13.203                      farnesoate epoxidase 
                EC 1.14.13.204                      long-chain acyl-CoA ω-monooxygenase 
                EC 1.14.13.205                      long-chain fatty acid ω-monooxygenase 
                EC 1.14.13.206                      laurate 7-monooxygenase 
                EC 1.14.13.207                      ipsdienol synthase. Now EC 1.14.14.31, ipsdienol synthase 
                EC 1.14.13.208                      benzoyl-CoA 2,3-epoxidase 
                EC 1.14.13.209                      salicyloyl-CoA 5-hydroxylase 
                EC 1.14.13.210                      4-methyl-5-nitrocatechol 5-monooxygenase 
                EC 1.14.13.211                      rifampicin monooxygenase 
                EC 1.14.13.212                      1,3,7-trimethyluric acid 5-monooxygenase 
                EC 1.14.13.213                      bursehernin 5′-monooxygenase 
                EC 1.14.13.214                      (–)-4′-demethyl-deoxypodophyllotoxin 4-hydroxylase 
                EC 1.14.13.215                      protoasukamycin 4-monooxygenase 
                EC 1.14.13.216                      asperlicin C monooxygenase 
                EC 1.14.13.217                      protodeoxyviolaceinate monooxygenase 
                EC 1.14.13.218                      5-methylphenazine-1-carboxylate 1-monooxygenase 
                EC 1.14.13.219                      resorcinol 4-hydroxylase (NADPH) 
                EC 1.14.13.220                      resorcinol 4-hydroxylase (NADH) 
                EC 1.14.13.221                      cholest-4-en-3-one 26-monooxygenase [(25R)-3-oxocholest-4-en-26-oate forming] 
                EC 1.14.13.222                      aurachin C monooxygenase/isomerase 
                EC 1.14.13.223                      3-hydroxy-4-methylanthranilyl-[aryl-carrier protein] 5-monooxygenase 
                EC 1.14.13.224                      violacein synthase 
                EC 1.14.13.225                      F-actin monooxygenase 
                EC 1.14.13.226                      acetone monooxygenase (methyl acetate-forming) 
                EC 1.14.13.227                      propane 2-monooxygenase 
                EC 1.14.13.228                      jasmonic acid 12-hydroxylase 
                EC 1.14.13.229                      tert-butyl alcohol monooxygenase 
                EC 1.14.13.230                      butane monooxygenase (soluble) 
                EC 1.14.13.231                      tetracycline 11a-monooxygenase 
                EC 1.14.13.232                      6-methylpretetramide 4-monooxygenase 
                EC 1.14.13.233                      4-hydroxy-6-methylpretetramide 12a-monooxygenase 
                EC 1.14.13.234                      5a,11a-dehydrotetracycline 5-monooxygenase 
        EC 1.14.14       []    With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor 
                EC 1.14.14.1                      unspecific monooxygenase 
                EC 1.14.14.2                       benzopyrene 3-monooxygenase. Now included with EC 1.14.14.1 unspecific monooxygenase 
                EC 1.14.14.3                      bacterial luciferase 
                EC 1.14.14.4                       choline monooxygenase. Identical to EC 1.14.15.7 
                EC 1.14.14.5                      alkanesulfonate monooxygenase 
                EC 1.14.14.6                      methanesulfonate monooxygenase. Now EC 1.14.13.111, methanesulfonate monooxygenase. Formerly thought to involve FMNH2 but now shown to use NADH. 
                EC 1.14.14.7                      tryptophan 7-halogenase. As oxygen is completely reduced to H2O and is not incorporated into the donor chloride, the enzyme has been transferred to EC 1.14.19.9, tryptophan 7-halogenase 
                EC 1.14.14.8                      anthranilate 3-monooxygenase (FAD) 
                EC 1.14.14.9                      4-hydroxyphenylacetate 3-monooxygenase 
                EC 1.14.14.10                      nitrilotriacetate monooxygenase 
                EC 1.14.14.11                      styrene monooxygenase 
                EC 1.14.14.12                      3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione monooxygenase 
                EC 1.14.14.13                      4-(γ-L-glutamylamino)butanoyl-[BtrI acyl-carrier protein] monooxygenase 
                EC 1.14.14.14                      aromatase 
                EC 1.14.14.15                      (3S)-3-amino-3-(3-chloro-4-hydroxyphenyl)propanoyl-[peptidyl-carrier protein SgcC2] monooxygenase 
                EC 1.14.14.16                      steroid 21-monooxygenase 
                EC 1.14.14.17                      squalene monooxygenase 
                EC 1.14.14.18                      heme oxygenase (biliverdin-producing) 
                EC 1.14.14.19                      steroid 17α-monooxygenase 
                EC 1.14.14.20                      phenol 2-monooxygenase (FADH2) 
                EC 1.14.14.21                      dibenzothiophene monooxygenase 
                EC 1.14.14.22                      dibenzothiophene sulfone monooxygenase 
                EC 1.14.14.23                      cholesterol 7α-monooxygenase 
                EC 1.14.14.24                      vitamin D 25-hydroxylase 
                EC 1.14.14.25                      cholesterol 24-hydroxylase 
                EC 1.14.14.26                      24-hydroxycholesterol 7α-hydroxylase 
                EC 1.14.14.27                      resorcinol 4-hydroxylase (FADH2) 
                EC 1.14.14.28                      long-chain alkane monooxygenase 
                EC 1.14.14.29                      25/26-hydroxycholesterol 7α-hydroxylase 
                EC 1.14.14.30                      isobutylamine N-monooxygenase 
                EC 1.14.14.31                      ipsdienol synthase 
                EC 1.14.14.32                      17α-hydroxyprogesterone deacetylase 
                EC 1.14.14.33                      ethylenediaminetetraacetate monooxygenase 
                EC 1.14.14.34                      methanesulfonate monooxygenase (FMNH2) 
                EC 1.14.14.35                      dimethylsulfone monooxygenase 
                EC 1.14.14.36                      tyrosine N-monooxygenase 
                EC 1.14.14.37                      4-hydroxyphenylacetaldehyde oxime monooxygenase 
                EC 1.14.14.38                      valine N-monooxygenase 
                EC 1.14.14.39                      isoleucine N-monooxygenase 
                EC 1.14.14.40                      phenylalanine N-monooxygenase 
                EC 1.14.14.41                      (E)-2-methylbutanal oxime monooxygenase 
                EC 1.14.14.42                      homomethionine N-monooxygenase 
                EC 1.14.14.43                      (methylthio)alkanaldoxime N-monooxygenase 
        EC 1.14.15       []    With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor 
                EC 1.14.15.1                      camphor 5-monooxygenase 
                EC 1.14.15.2                      camphor 1,2-monooxygenase. Now EC 1.14.13.162, 2,5-diketocamphane 1,2-monooxygenase. 
                EC 1.14.15.3                      alkane 1-monooxygenase 
                EC 1.14.15.4                      steroid 11β-monooxygenase 
                EC 1.14.15.5                      corticosterone 18-monooxygenase 
                EC 1.14.15.6                      cholesterol monooxygenase (side-chain-cleaving) 
                EC 1.14.15.7                      choline monooxygenase 
                EC 1.14.15.8                      steroid 15β-monooxygenase 
                EC 1.14.15.9                      spheroidene monooxygenase 
                EC 1.14.15.10                      (+)-camphor 6-endo-hydroxylase 
                EC 1.14.15.11                      pentalenic acid synthase 
                EC 1.14.15.12                      pimeloyl-[acyl-carrier protein] synthase 
                EC 1.14.15.13                      pulcherriminic acid synthase 
                EC 1.14.15.14                      methyl-branched lipid ω-hydroxylase 
                EC 1.14.15.15                      cholestanetriol 26-monooxygenase 
                EC 1.14.15.16                      vitamin D3 24-hydroxylase 
                EC 1.14.15.17                      pheophorbide a oxygenase 
                EC 1.14.15.18                      calcidiol 1-monooxygenase 
                EC 1.14.15.19                      C-19 steroid 1α-hydroxylase 
                EC 1.14.15.20                      heme oxygenase (biliverdin-producing, ferredoxin) 
                EC 1.14.15.21                      zeaxanthin epoxidase 
                EC 1.14.15.22                      vitamin D 1,25-hydroxylase 
        EC 1.14.16       []    With reduced pteridine as one donor, and incorporation of one atom of oxygen into the other donor 
                EC 1.14.16.1                      phenylalanine 4-monooxygenase 
                EC 1.14.16.2                      tyrosine 3-monooxygenase 
                EC 1.14.16.3                      anthranilate 3-monooxygenase 
                EC 1.14.16.4                      tryptophan 5-monooxygenase 
                EC 1.14.16.5                      alkylglycerol monooxygenase 
                EC 1.14.16.6                      mandelate 4-monooxygenase 
                EC 1.14.16.7                      phenylalanine 3-monooxygenase  
        EC 1.14.17       []    With reduced ascorbate as one donor, and incorporation of one atom of oxygen into the other donor 
                EC 1.14.17.1                      dopamine β-monooxygenase 
                EC 1.14.17.2                       4-coumarate 3-monooxygenase. Now included with EC 1.14.18.1 monophenol monooxygenase 
                EC 1.14.17.3                      peptidylglycine monooxygenase 
                EC 1.14.17.4                      aminocyclopropanecarboxylate oxidase 
        EC 1.14.18       []    With another compound as one donor, and incorporation of one atom of oxygen into the other donor 
                EC 1.14.18.1                      tyrosinase 
                EC 1.14.18.2                      CMP-N-acetylneuraminate monooxygenase 
                EC 1.14.18.3                      methane monooxygenase (particulate) 
                EC 1.14.18.4                      phosphatidylcholine 12-monooxygenase 
                EC 1.14.18.5                      sphingolipid C4-monooxygenase 
                EC 1.14.18.6                      4-hydroxysphinganine ceramide fatty acyl 2-hydroxylase 
                EC 1.14.18.7                      dihydroceramide fatty acyl 2-hydroxylase 
                EC 1.14.18.8                      7α-hydroxycholest-4-en-3-one 12α-hydroxylase 
        EC 1.14.19       []    With oxidation of a pair of donors resulting in the reduction of O2 to two molecules of water 
                EC 1.14.19.1                      stearoyl-CoA 9-desaturase 
                EC 1.14.19.2                      stearoyl-[acyl-carrier-protein] 9-desaturase 
                EC 1.14.19.3                      acyl-CoA 6-desaturase 
                EC 1.14.19.4                      acyl-lipid (11-3)-desaturase 
                EC 1.14.19.5                      acyl-CoA 11-(Z)-desaturase 
                EC 1.14.19.6                      acyl-CoA (9+3)-desaturase 
                EC 1.14.19.7                      (S)-2-hydroxypropylphosphonic acid epoxidase. Now EC 1.11.1.23, (S)-2-hydroxypropylphosphonic acid epoxidase. 
                EC 1.14.19.8                      pentalenolactone synthase 
                EC 1.14.19.9                      tryptophan 7-halogenase 
                EC 1.14.19.10                      icosanoyl-CoA 5-desaturase 
                EC 1.14.19.11                      acyl-[acyl-carrier-protein] 4-desaturase 
                EC 1.14.19.12                      acyl-lipid ω-(9-4) desaturase 
                EC 1.14.19.13                      acyl-CoA 15-desaturase 
                EC 1.14.19.14                      linoleoyl-lipid Δ9 conjugase 
                EC 1.14.19.15                      (11Z)-hexadec-11-enoyl-CoA conjugase 
                EC 1.14.19.16                      linoleoyl-lipid Δ12 conjugase (11E,13Z-forming) 
                EC 1.14.19.17                      sphingolipid 4-desaturase 
                EC 1.14.19.18                      sphingolipid 8-(E)-desaturase 
                EC 1.14.19.19                      sphingolipid 10-desaturase 
                EC 1.14.19.20                      Δ7-sterol 5(6)-desaturase 
                EC 1.14.19.21                      cholesterol 7-desaturase 
                EC 1.14.19.22                      acyl-lipid ω-6 desaturase (cytochrome b5) 
                EC 1.14.19.23                      acyl-lipid (n+3)-(Z)-desaturase (ferredoxin) 
                EC 1.14.19.24                      acyl-CoA 11-(E)-desaturase 
                EC 1.14.19.25                      acyl-lipid ω-3 desaturase (cytochrome b5) 
                EC 1.14.19.26                      acyl-[acyl-carrier-protein] 6-desaturase 
                EC 1.14.19.27                      sn-2 palmitoyl-lipid 9-desaturase 
                EC 1.14.19.28                      sn-1 stearoyl-lipid 9-desaturase 
                EC 1.14.19.29                      sphingolipid 8-(E/Z)-desaturase 
                EC 1.14.19.30                      acyl-lipid (8-3)-desaturase 
                EC 1.14.19.31                      acyl-lipid (7-3)-desaturase 
                EC 1.14.19.32                      palmitoyl-CoA 14-(E/Z)-desaturase 
                EC 1.14.19.33                      Δ12 acyl-lipid conjugase (11E,13E-forming) 
                EC 1.14.19.34                      acyl-lipid (9+3)-(E)-desaturase 
                EC 1.14.19.35                      sn-2 acyl-lipid ω-3 desaturase (ferredoxin) 
                EC 1.14.19.36                      sn-1 acyl-lipid ω-3 desaturase (ferredoxin) 
                EC 1.14.19.37                      acyl-CoA 5-desaturase 
                EC 1.14.19.38                      acyl-lipid Δ6-acetylenase 
                EC 1.14.19.39                      acyl-lipid Δ12-acetylenase 
                EC 1.14.19.40                      hex-5-enoyl-[acyl-carrier protein] acetylenase 
                EC 1.14.19.41                      sterol 22-desaturase 
                EC 1.14.19.42                      palmitoyl-[glycerolipid] 7-desaturase 
                EC 1.14.19.43                      palmitoyl-[glycerolipid] 3-(E)-desaturase 
                EC 1.14.19.44                      acyl-CoA (8-3)-desaturase 
                EC 1.14.19.45                      sn-1 oleoyl-lipid 12-desaturase 
                EC 1.14.19.46                      sn-1 linoleoyl-lipid 6-desaturase 
                EC 1.14.19.47                      acyl-lipid (9-3)-desaturase 
                EC 1.14.19.48                      tert-amyl alcohol desaturase 
                EC 1.14.19.49                      tetracycline 7-halogenase 
                EC 1.14.19.50                      noroxomaritidine synthase 
        EC 1.14.20       []    With 2-oxoglutarate as one donor, and the other dehydrogenated 
                EC 1.14.20.1                      deacetoxycephalosporin-C synthase 
                EC 1.14.20.2                      2,4-dihydroxy-1,4-benzoxazin-3-one-glucoside dioxygenase 
                EC 1.14.20.3                      (5R)-carbapenem-3-carboxylate synthase 
        EC 1.14.21       []    With NADH or NADPH as one donor, and the other dehydrogenated 
                EC 1.14.21.1                      (S)-stylopine synthase 
                EC 1.14.21.2                      (S)-cheilanthifoline synthase 
                EC 1.14.21.3                      berbamunine synthase 
                EC 1.14.21.4                      salutaridine synthase 
                EC 1.14.21.5                      (S)-canadine synthase 
                EC 1.14.21.6                      lathosterol oxidase. Now EC 1.14.19.20, Δ7-sterol 5(6)-desaturase 
                EC 1.14.21.7                      biflaviolin synthase 
                EC 1.14.21.8                      pseudobaptigenin synthase 
                EC 1.14.21.9                      mycocyclosin synthase 
                EC 1.14.21.10                      fumitremorgin C synthase 
                EC 1.14.21.11                      (–)-pluviatolide synthase 
                EC 1.14.21.12                      (S)-nandinine synthase 
        EC 1.14.99       []    Miscellaneous 
                EC 1.14.99.1                      prostaglandin-endoperoxide synthase 
                EC 1.14.99.2                      kynurenine 7,8-hydroxylase 
                EC 1.14.99.3                      heme oxygenase (biliverdin-producing). Now EC 1.14.14.18, heme oxygenase (biliverdin-producing) 
                EC 1.14.99.4                      progesterone monooxygenase 
                EC 1.14.99.5                      stearoyl-CoA desaturase. Now EC 1.14.19.1, stearoyl-CoA 9-desaturase 
                EC 1.14.99.6                      acyl-[acyl-carrier-protein] desaturase. Now EC 1.14.19.2, acyl-[acyl-carrier-protein] desaturase 
                EC 1.14.99.7                      squalene monooxygenase. Transferred to EC 1.14.13.132, squalene monooxygenase. 
                EC 1.14.99.8                       arene monooxygenase (epoxidizing). Now included with EC 1.14.14.1 unspecific monooxygenase 
                EC 1.14.99.9                      steroid 17α-monooxygenase, now classified as EC 1.14.14.19, steroid 17α-monooxygenase 
                EC 1.14.99.10                      steroid 21-monooxygenase. Now EC 1.14.14.16, steroid 21-monooxygenase 
                EC 1.14.99.11                      estradiol 6β-monooxygenase 
                EC 1.14.99.12                      androst-4-ene-3,17-dione monooxygenase 
                EC 1.14.99.13                      3-hydroxybenzoate 4-monooxygenase. Now EC 1.14.13.23, 3-hydroxybenzoate 4-monooxygenase 
                EC 1.14.99.14                      progesterone 11α-monooxygenase 
                EC 1.14.99.15                      4-methoxybenzoate monooxygenase (O-demethylating) 
                EC 1.14.99.16                      methylsterol monooxygenase. Now EC 1.14.13.72, methylsterol monooxygenase 
                EC 1.14.99.17                      glyceryl-ether monooxygenase. Now EC 1.14.16.5, glyceryl-ether monooxygenase 
                EC 1.14.99.18                       CMP-N-acetylneuraminate monooxygenase 
                EC 1.14.99.19                      plasmanylethanolamine desaturase 
                EC 1.14.99.20                      phylloquinone monooxygenase (2,3-epoxidizing) 
                EC 1.14.99.21                      Latia-luciferin monooxygenase (demethylating) 
                EC 1.14.99.22                      ecdysone 20-monooxygenase 
                EC 1.14.99.23                      3-hydroxybenzoate 2-monooxygenase 
                EC 1.14.99.24                      steroid 9α-monooxygenase 
                EC 1.14.99.25                      linoleoyl-CoA desaturase. Now EC 1.14.19.3, linoleoyl-CoA desaturase 
                EC 1.14.99.26                      2-hydroxypyridine 5-monooxygenase 
                EC 1.14.99.27                      juglone 3-monooxygenase, now classified as EC 1.17.3.4, juglone 3-monooxygenase 
                EC 1.14.99.28                      linalool 8-monooxygenase. Now EC 1.14.13.151, linalool 8-monooxygenase 
                EC 1.14.99.29                      deoxyhypusine monooxygenase 
                EC 1.14.99.30                      carotene 7,8-desaturase. Now EC 1.3.5.6, 9,9′-dicis-ζ-carotene desaturase. 
                EC 1.14.99.31                      myristoyl-CoA 11-(E) desaturase. Now classified as EC 1.14.19.24, myristoyl-CoA 11-(E) desaturase 
                EC 1.14.99.32                      myristoyl-CoA 11-(Z) desaturase. Now classified as EC 1.14.19.5, acyl-CoA 11-(Z)-desaturase. 
                EC 1.14.99.33                      Δ12-fatty acid dehydrogenase. Now EC 1.14.19.39, acyl-lipid Δ12-acetylenase 
                EC 1.14.99.34                      monoprenyl isoflavone epoxidase 
                EC 1.14.99.35                      thiophene-2-carbonyl-CoA monooxygenase 
                EC 1.14.99.36                      β-carotene 15,15-monooxygenase. Now classified as EC 1.13.11.63, β-carotene 15,15′-dioxygenase. 
                EC 1.14.99.37                      taxadiene 5α-hydroxylase 
                EC 1.14.99.38                      cholesterol 25-hydroxylase 
                EC 1.14.99.39                      ammonia monooxygenase 
                EC 1.14.99.40                      5,6-dimethylbenzimidazole synthase. Now EC 1.13.11.79, 5,6-dimethylbenzimidazole synthase 
                EC 1.14.99.41                      all-trans-8′-apo-β-carotenal 15,15′-oxygenase. Now EC 1.13.11.75, all-trans-8′-apo-β-carotenal 15,15′-oxygenase 
                EC 1.14.99.42                      zeaxanthin 7,8-dioxygenase 
                EC 1.14.99.43                      β-amyrin 24-hydroxylase 
                EC 1.14.99.44                      diapolycopene oxygenase 
                EC 1.14.99.45                      carotene ε-monooxygenase 
                EC 1.14.99.46                      pyrimidine oxygenase 
                EC 1.14.99.47                      (+)-larreatricin hydroxylase 
                EC 1.14.99.48                      heme oxygenase (staphylobilin-producing) 
                EC 1.14.99.49                      2-hydroxy-5-methyl-1-naphthoate 7-hydroxylase 
                EC 1.14.99.50                      γ-glutamyl hercynylcysteine S-oxide synthase 
                EC 1.14.99.51                      hercynylcysteine S-oxide synthase 
                EC 1.14.99.52                      L-cysteinyl-L-histidinylsulfoxide synthase 
                EC 1.14.99.53                      lytic chitin monoxygenase 
    EC 1.15  [+]      
        EC 1.15.1       []    Acting on superoxide as acceptor (only sub-subclass identified to date) 
                EC 1.15.1.1                      superoxide dismutase 
                EC 1.15.1.2                      superoxide reductase 
    EC 1.16  [+]      
        EC 1.16.1       []    With NAD+ or NADP+ as acceptor 
                EC 1.16.1.1                      mercury(II) reductase 
                EC 1.16.1.2                      diferric-transferrin reductase 
                EC 1.16.1.3                      aquacobalamin reductase 
                EC 1.16.1.4                      cob(II)alamin reductase 
                EC 1.16.1.5                      aquacobalamin reductase (NADPH) 
                EC 1.16.1.6                      cyanocobalamin reductase (cyanide-eliminating) 
                EC 1.16.1.7                      ferric-chelate reductase (NADH) 
                EC 1.16.1.8                      [methionine synthase] reductase 
                EC 1.16.1.9                      ferric-chelate reductase (NADPH) 
                EC 1.16.1.10                      ferric-chelate reductase [NAD(P)H] 
        EC 1.16.3       []    With oxygen as acceptor 
                EC 1.16.3.1                      ferroxidase 
                EC 1.16.3.2                      bacterial non-heme ferritin 
        EC 1.16.5       []    With a quinone or similar compound as acceptor 
                EC 1.16.5.1                      ascorbate ferrireductase (transmembrane) 
        EC 1.16.8       []    With a flavin as acceptor 
                EC 1.16.8.1                      cob(II)yrinic acid a,c-diamide reductase 
        EC 1.16.9       []    With a copper protein as acceptor 
                EC 1.16.9.1                      iron:rusticyanin reductase 
        EC 1.16.98       []    With other, known, physiological acceptors 
                EC 1.16.98.1                      Now EC 1.16.9.1 iron:rusticyanin reductase 
    EC 1.17  [+]      
        EC 1.17.1       []    With NAD+ or NADP+ as acceptor 
                EC 1.17.1.1                      CDP-4-dehydro-6-deoxyglucose reductase 
                EC 1.17.1.2                      4-hydroxy-3-methylbut-2-enyl diphosphate reductase, now classified as EC 1.17.7.4, 4-hydroxy-3-methylbut-2-enyl diphosphate reductase. 
                EC 1.17.1.3                      leucoanthocyanidin reductase 
                EC 1.17.1.4                      xanthine dehydrogenase 
                EC 1.17.1.5                      nicotinate dehydrogenase 
                EC 1.17.1.6                      bile-acid 7α-dehydroxylase. Now EC 1.17.99.5, bile-acid 7α-dehydroxylase. It is now known that FAD is the acceptor and not NAD+ as was thought previously 
                EC 1.17.1.7                      3-oxo-5,6-dehydrosuberyl-CoA semialdehyde dehydrogenase. Now EC 1.2.1.91, 3-oxo-5,6-dehydrosuberyl-CoA semialdehyde dehydrogenase 
                EC 1.17.1.8                      4-hydroxy-tetrahydrodipicolinate reductase 
        EC 1.17.2       []    With a cytochrome as acceptor 
                EC 1.17.2.1                      nicotinate dehydrogenase (cytochrome) 
                EC 1.17.2.2                      lupanine 17-hydroxylase (cytochrome c) 
        EC 1.17.3       []    With oxygen as acceptor 
                EC 1.17.3.1                      pteridine oxidase 
                EC 1.17.3.2                      xanthine oxidase 
                EC 1.17.3.3                      6-hydroxynicotinate dehydrogenase 
                EC 1.17.3.4                      juglone 3-hydroxylase 
        EC 1.17.4       []    With a disulfide as acceptor 
                EC 1.17.4.1                      ribonucleoside-diphosphate reductase 
                EC 1.17.4.2                      ribonucleoside-triphosphate reductase (thioredoxin) 
                EC 1.17.4.3                      4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase. As ferredoxin and not protein-disulfide is now known to take part in the reaction, the enzyme has been transferred to EC 1.17.7.1, (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase. 
                EC 1.17.4.4                      vitamin-K-epoxide reductase (warfarin-sensitive) 
                EC 1.17.4.5                      vitamin-K-epoxide reductase (warfarin-insensitive) 
        EC 1.17.5       []    With a quinone or similar compound as acceptor 
                EC 1.17.5.1                      phenylacetyl-CoA dehydrogenase 
                EC 1.17.5.2                      caffeine dehydrogenase 
        EC 1.17.7       []    With an iron-sulfur protein as acceptor 
                EC 1.17.7.1                      (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase (ferredoxin) 
                EC 1.17.7.2                      7-hydroxymethyl chlorophyll a reductase 
                EC 1.17.7.3                      (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase (flavodoxin) 
                EC 1.17.7.4                      4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase 
        EC 1.17.8       []    With a flavin as acceptor 
                EC 1.17.8.1                      hydroxysqualene dehydroxylase 
        EC 1.17.98       []    With other, known, physiological acceptors 
                EC 1.17.98.1                      bile-acid 7α-dehydroxylase. Now known to be catalyzed by multiple enzymes. 
                EC 1.17.98.2                      bacteriochlorophyllide c C-71-hydroxylase 
        EC 1.17.99       []    With unknown physiological acceptors 
                EC 1.17.99.1                      4-methylphenol dehydrogenase (hydroxylating) 
                EC 1.17.99.2                      ethylbenzene hydroxylase 
                EC 1.17.99.3                      3α,7α,12α-trihydroxy-5β-cholestanoyl-CoA 24-hydroxylase 
                EC 1.17.99.4                      uracil/thymine dehydrogenase 
                EC 1.17.99.5                      bile-acid 7α-dehydroxylase. Now classified as EC 1.17.98.1, bile-acid 7α-dehydroxylase. 
                EC 1.17.99.6                      epoxyqueuosine reductase 
    EC 1.18  [+]      
        EC 1.18.1       []    With NAD+ or NADP+ as acceptor 
                EC 1.18.1.1                      rubredoxin—NAD+ reductase 
                EC 1.18.1.2                      ferredoxin—NADP+ reductase 
                EC 1.18.1.3                      ferredoxin—NAD+ reductase 
                EC 1.18.1.4                      rubredoxin—NAD(P)+ reductase 
                EC 1.18.1.5                      putidaredoxin—NAD+ reductase 
                EC 1.18.1.6                      adrenodoxin-NADP+ reductase 
                EC 1.18.1.7                      ferredoxin—NAD(P)+ reductase (naphthalene dioxygenase ferredoxin-specific) 
                EC 1.18.1.8                      ferredoxin-NAD+ oxidoreductase (Na+-transporting) 
        EC 1.18.2       []    With dinitrogen as acceptor (deleted sub-subclass) 
                EC 1.18.2.1                      now EC 1.18.6.1, nitrogenase 
        EC 1.18.3       []    With H+ as acceptor (deleted sub-subclass) 
                EC 1.18.3.1                      hydrogenase. Now EC 1.12.7.2, ferredoxin hydrogenase 
        EC 1.18.6       []    With dinitrogen as acceptor 
                EC 1.18.6.1                      nitrogenase 
        EC 1.18.96       []    With other, known, acceptors (deleted sub-subclass) 
                EC 1.18.96.1                      superoxide reductase. Now EC 1.15.1.2, superoxide reductase 
        EC 1.18.99       []    With H+ as acceptor (deleted sub-subclass) 
                EC 1.18.99.1                      hydrogenase. Now EC 1.12.7.2, ferredoxin hydrogenase 
    EC 1.19  [+]      
        EC 1.19.1       []    With NAD+ or NADP+ as acceptor 
                EC 1.19.1.1                      flavodoxin—NADP+ reductase 
        EC 1.19.6       []    With dinitrogen as acceptor 
                EC 1.19.6.1                      nitrogenase (flavodoxin) 
    EC 1.20  [+]      
        EC 1.20.1       []    With NAD+ or NADP+ as acceptor 
                EC 1.20.1.1                      phosphonate dehydrogenase 
        EC 1.20.2       []    With a cytochrome as acceptor 
                EC 1.20.2.1                      arsenate reductase (cytochrome c) 
        EC 1.20.4       []    With disulfide as acceptor 
                EC 1.20.4.1                      arsenate reductase (glutaredoxin) 
                EC 1.20.4.2                      methylarsonate reductase 
                EC 1.20.4.3                      mycoredoxin 
                EC 1.20.4.4                      arsenate reductase (thioredoxin) 
        EC 1.20.9       []    With a copper protein as acceptor 
                EC 1.20.9.1                      arsenate reductase (azurin) 
        EC 1.20.98       []    With other, known, physiological acceptors 
                EC 1.20.98.1                      arsenate reductase (azurin). Now EC 1.20.9.1, arsenate reductase (azurin) 
        EC 1.20.99       []    With unknown physiological acceptors 
                EC 1.20.99.1                      arsenate reductase (donor) 
    EC 1.21  [+]      
        EC 1.21.3       []    With oxygen as acceptor 
                EC 1.21.3.1                      isopenicillin-N synthase 
                EC 1.21.3.2                      columbamine oxidase 
                EC 1.21.3.3                      reticuline oxidase 
                EC 1.21.3.4                      sulochrin oxidase [(+)-bisdechlorogeodin-forming] 
                EC 1.21.3.5                      sulochrin oxidase [(-)-bisdechlorogeodin-forming] 
                EC 1.21.3.6                      aureusidin synthase 
                EC 1.21.3.7                      tetrahydrocannabinolic acid synthase 
                EC 1.21.3.8                      cannabidiolic acid synthase 
                EC 1.21.3.9                      dichlorochromopyrrolate synthase, now classified as EC 1.21.98.2, dichlorochromopyrrolate synthase 
        EC 1.21.4       []    With a disulfide as acceptor 
                EC 1.21.4.1                      D-proline reductase (dithiol) 
                EC 1.21.4.2                      glycine reductase 
                EC 1.21.4.3                      sarcosine reductase 
                EC 1.21.4.4                      betaine reductase 
        EC 1.21.98       []    With other, known, physiological acceptors 
                EC 1.21.98.1                      cyclic dehypoxanthinyl futalosine synthase 
                EC 1.21.98.2                      dichlorochromopyrrolate synthase 
                EC 1.21.98.3                      anaerobic magnesium-protoporphyrin IX monomethyl ester cyclase 
        EC 1.21.99       []    With unknown physiological acceptors 
                EC 1.21.99.1                      β-cyclopiazonate dehydrogenase 
                EC 1.21.99.2                      EC 1.21.99.2, cyclic dehypoxanthinyl futalosine synthase. Now classified as EC 1.21.98.1, cyclic dehypoxanthinyl futalosine synthase. 
                EC 1.21.99.3                      thyroxine 5-deiodinase 
                EC 1.21.99.4                      thyroxine 5′-deiodinase 
                EC 1.21.99.5                      tetrachloroethene reductive dehalogenase 
    EC 1.22  [+]      
        EC 1.22.1       []    With NAD+ or NADP+ as acceptor 
                EC 1.22.1.1                      iodotyrosine deiodinase. Now EC 1.21.1.1, iodotyrosine deiodinase 
    EC 1.23  [+]      
        EC 1.23.1       []    With NADH or NADPH as donor 
                EC 1.23.1.1                      (+)-pinoresinol reductase 
                EC 1.23.1.2                      (+)-lariciresinol reductase 
                EC 1.23.1.3                      (–)-pinoresinol reductase 
                EC 1.23.1.4                      (–)-lariciresinol reductase 
        EC 1.23.5       []    With a quinone or similar compound as acceptor 
                EC 1.23.5.1                      violaxanthin de-epoxidase 
    EC 1.97  [+]      
        EC 1.97.1       []    Sole sub-subclass for oxidoreductases that do not belong in the other subclasses 
                EC 1.97.1.1                      chlorate reductase 
                EC 1.97.1.2                      pyrogallol hydroxytransferase 
                EC 1.97.1.3                      sulfur reductase. Now EC 1.12.98.4, sulfhydrogenase, since hydrogen is known to be the electron donor. 
                EC 1.97.1.4                      [formate-C-acetyltransferase]-activating enzyme 
                EC 1.97.1.5                      arsenate reductase (glutaredoxin). Now EC 1.20.4.1, arsenate reductase (glutaredoxin) 
                EC 1.97.1.6                      arsenate reductase (donor). Now EC 1.20.99.1, arsenate reductase (donor) 
                EC 1.97.1.7                      methylarsonate reductase. Now EC 1.20.4.2, methylarsonate reductase 
                EC 1.97.1.8                      tetrachloroethene reductive dehalogenase. Now EC 1.21.99.5, tetrachloroethene reductive dehalogenase 
                EC 1.97.1.9                      selenate reductase 
                EC 1.97.1.10                      thyroxine 5′-deiodinase. Now EC 1.21.99.4 thyroxine 5′-deiodinase 
                EC 1.97.1.11                      thyroxine 5-deiodinase. Now EC 1.21.99.3 thyroxine 5-deiodinase. 
                EC 1.97.1.12                      photosystem I 
    EC 1.98  [+]      
    EC 1.99  [+]      
        EC 1.99.1       []    Hydroxylases (now covered by EC 1.14) 
                EC 1.99.1.1                      Now EC 1.12.7.2, ferredoxin hydrogenase 
                EC 1.99.1.2                      Now EC 1.14.16.1, phenylalanine 4-monooxygenase 
                EC 1.99.1.3                      nicotinate 6-hydroxylase 
                EC 1.99.1.4                      tryptophan 5-hydroxylase 
                EC 1.99.1.5                      Now EC 1.14.13.9, kynurenine 3-monooxygenase 
                EC 1.99.1.6                      steroid 11α-hydroxylase 
                EC 1.99.1.7                      Now EC 1.14.15.4, steroid 11β-monooxygenase 
                EC 1.99.1.8                      steroid 6β-hydroxylase 
                EC 1.99.1.9                      Now EC 1.14.99.9, steroid 17α-monooxygenase 
                EC 1.99.1.10                      steroid 19-hydroxylase 
                EC 1.99.1.11                      Now EC 1.14.99.10, steroid 21-monooxygenase 
                EC 1.99.1.12                      alkoxyaryl hydroxylase 
                EC 1.99.1.13                      squalene cyclohydroxylase, covered by EC 1.14.99.7 (squalene monooxygenase) and by EC 5.4.99.7 (lanosterol synthase) 
                EC 1.99.1.14                      Now EC 1.13.11.27, 4-hydroxyphenylpyruvate dioxygenase 
        EC 1.99.2       []    Oxygenases (now covered by EC 1.13) 
                EC 1.99.2.1                      Now EC 1.13.11.12, lipoxygenase 
                EC 1.99.2.2                      Now EC 1.13.11.1, catechol 1,2-dioxygenase 
                EC 1.99.2.3                      Now EC 1.13.11.3, protocatechuate 3,4-dioxygenase 
                EC 1.99.2.4                      Now EC 1.13.11.4, gentisate 1,2-dioxygenase 
                EC 1.99.2.5                      Now EC 1.13.11.5, homogentisate 1,2-dioxygenase 
                EC 1.99.2.6                      Now EC 1.13.99.1, inositol oxygenase 
EC 2 [+]   
    EC 2.1  [+]      
        EC 2.1.1       []    Methyltransferases 
                EC 2.1.1.1                      nicotinamide N-methyltransferase 
                EC 2.1.1.2                      guanidinoacetate N-methyltransferase 
                EC 2.1.1.3                      thetin—homocysteine S-methyltransferase 
                EC 2.1.1.4                      acetylserotonin O-methyltransferase 
                EC 2.1.1.5                      betaine—homocysteine S-methyltransferase 
                EC 2.1.1.6                      catechol O-methyltransferase 
                EC 2.1.1.7                      nicotinate N-methyltransferase 
                EC 2.1.1.8                      histamine N-methyltransferase 
                EC 2.1.1.9                      thiol S-methyltransferase 
                EC 2.1.1.10                      homocysteine S-methyltransferase 
                EC 2.1.1.11                      magnesium protoporphyrin IX methyltransferase 
                EC 2.1.1.12                      methionine S-methyltransferase 
                EC 2.1.1.13                      methionine synthase 
                EC 2.1.1.14                      5-methyltetrahydropteroyltriglutamate—homocysteine S-methyltransferase 
                EC 2.1.1.15                      fatty-acid O-methyltransferase 
                EC 2.1.1.16                      methylene-fatty-acyl-phospholipid synthase 
                EC 2.1.1.17                      phosphatidylethanolamine N-methyltransferase 
                EC 2.1.1.18                      polysaccharide O-methyltransferase 
                EC 2.1.1.19                      trimethylsulfonium—tetrahydrofolate N-methyltransferase 
                EC 2.1.1.20                      glycine N-methyltransferase 
                EC 2.1.1.21                      methylamine—glutamate N-methyltransferase 
                EC 2.1.1.22                      carnosine N-methyltransferase 
                EC 2.1.1.23                       protein-arginine N-methyltransferase. Now listed as EC 2.1.1.124 [cytochrome c]-arginine N-methyltransferase, EC 2.1.1.125 histone-arginine N-methyltransferase and EC 2.1.1.126 [myelin basic protein]-arginine N-methyltransferase 
                EC 2.1.1.24                       protein-γ-glutamate O-methyltransferase. Now listed as EC 2.1.1.77 protein-L-isoaspartate(D-aspartate) O-methyltransferase, EC 2.1.1.80 protein-glutamate O-methyltransferase and EC 2.1.1.100 protein-S-isoprenylcysteine O-methyltransferase 
                EC 2.1.1.25                      phenol O-methyltransferase 
                EC 2.1.1.26                      iodophenol O-methyltransferase 
                EC 2.1.1.27                      tyramine N-methyltransferase 
                EC 2.1.1.28                      phenylethanolamine N-methyltransferase 
                EC 2.1.1.29                      tRNA (cytosine-5-)-methyltransferase. Now covered by EC 2.1.1.202 [multisite-specific tRNA:(cytosine-C5)-methyltransferase], EC 2.1.1.203 [tRNA (cytosine34-C5)-methyltransferase] and EC 2.1.1.204 [RNA (cytosine38-C5)-methyltransferase]. 
                EC 2.1.1.30                      tRNA (purine-2- or -6-)-methyltransferase. Reactions previously described are due to EC 2.1.1.32 tRNA (guanine-N2-)-methyltransferase 
                EC 2.1.1.31                      tRNA (guanine-N1-)-methyltransferase. Now covered by EC 2.1.1.221 (tRNA (guanine9-N1)-methyltransferase) and EC 2.1.1.228 (tRNA (guanine37-N1)-methyltransferase). 
                EC 2.1.1.32                      tRNA (guanine-N2-)-methyltransferase. Now covered by EC 2.1.1.213 [tRNA (guanine10-N2)-dimethyltransferase], EC 2.1.1.214 [tRNA (guanine10-N2)-monomethyltransferase], EC 2.1.1.215 [tRNA (guanine26-N2/guanine27-N2)-dimethyltransferase] and EC 2.1.1.216 [tRNA (guanine26-N2)-dimethyltransferase] 
                EC 2.1.1.33                      tRNA (guanine46-N7)-methyltransferase 
                EC 2.1.1.34                      tRNA (guanosine18-2′-O)-methyltransferase 
                EC 2.1.1.35                      tRNA (uracil54-C5)-methyltransferase 
                EC 2.1.1.36                      tRNA (adenine-N1-)-methyltransferase. Now covered by EC 2.1.1.217 (tRNA (adenine22-N1)-methyltransferase), EC 2.1.1.218 (tRNA (adenine9-N1)-methyltransferase), EC 2.1.1.219 (tRNA (adenine57-N1/adenine58-N1)-methyltransferase), EC 2.1.1.220 (tRNA (adenine58-N1)-methyltransferase). 
                EC 2.1.1.37                      DNA (cytosine-5-)-methyltransferase 
                EC 2.1.1.38                      O-demethylpuromycin O-methyltransferase 
                EC 2.1.1.39                      inositol 3-methyltransferase 
                EC 2.1.1.40                      inositol 1-methyltransferase 
                EC 2.1.1.41                      sterol 24-C-methyltransferase 
                EC 2.1.1.42                      flavone 3′-O-methyltransferase 
                EC 2.1.1.43                      histone-lysine N-methyltransferase 
                EC 2.1.1.44                      L-histidine Nα-methyltransferase 
                EC 2.1.1.45                      thymidylate synthase 
                EC 2.1.1.46                      isoflavone 4′-O-methyltransferase 
                EC 2.1.1.47                      indolepyruvate C-methyltransferase 
                EC 2.1.1.48                      rRNA (adenine-N6-)-methyltransferase. Now covered by EC 2.1.1.181 [23S rRNA (adenine1618-N6)-methyltransferase], EC 2.1.1.182 [16S rRNA adenine1518-N6/adenine1519-N6)-dimethyltransferase], EC 2.1.1.183 [18S rRNA (adenine1779-N6/adenine1780-N6)-dimethyltransferase] and EC 2.1.1.184 [23S rRNA (adenine2085-N6)-dimethyltransferase] 
                EC 2.1.1.49                      amine N-methyltransferase 
                EC 2.1.1.50                      loganate O-methyltransferase 
                EC 2.1.1.51                      rRNA (guanine-N1-)-methyltransferase. Now covered by EC 2.1.1.187 [23S rRNA (guanine745-N1)-methyltransferase] and EC 2.1.1.188 [23S rRNA (guanine748-N1)-methyltransferase]. 
                EC 2.1.1.52                      rRNA (guanine-N2-)-methyltransferase. Now covered by EC 2.1.1.171 [16S rRNA (guanine966-N2)-methyltransferase], EC 2.1.1.172 [16S rRNA (guanine1207-N2)-methyltransferase], EC 2.1.1.173 [23S rRNA (guanine2445-N2)-methyltransferase] and EC 2.1.1.174 [23S rRNA (guanine1835-N2)-methyltransferase] 
                EC 2.1.1.53                      putrescine N-methyltransferase 
                EC 2.1.1.54                      deoxycytidylate C-methyltransferase 
                EC 2.1.1.55                      tRNA (adenine-N6-)-methyltransferase 
                EC 2.1.1.56                      mRNA (guanine-N7)-methyltransferase 
                EC 2.1.1.57                      methyltransferase cap1 
                EC 2.1.1.58                      mRNA (adenosine-2′-O-)-methyltransferase. Now included with EC 2.1.1.57, mRNA (nucleoside-2′-O-)-methyltransferase 
                EC 2.1.1.59                      [cytochrome c]-lysine N-methyltransferase 
                EC 2.1.1.60                      calmodulin-lysine N-methyltransferase 
                EC 2.1.1.61                      tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase 
                EC 2.1.1.62                      mRNA (2′-O-methyladenosine-N6-)-methyltransferase 
                EC 2.1.1.63                      methylated-DNA—[protein]-cysteine S-methyltransferase 
                EC 2.1.1.64                      3-demethylubiquinol 3-O-methyltransferase 
                EC 2.1.1.65                      licodione 2′-O-methyltransferase 
                EC 2.1.1.66                      rRNA (adenosine-2′-O-)-methyltransferase. Now covered by EC 2.1.1.230, 23S rRNA (adenosine1067-2-O)-methyltransferase. 
                EC 2.1.1.67                      thiopurine S-methyltransferase 
                EC 2.1.1.68                      caffeate O-methyltransferase 
                EC 2.1.1.69                      5-hydroxyfuranocoumarin 5-O-methyltransferase 
                EC 2.1.1.70                      8-hydroxyfuranocoumarin 8-O-methyltransferase 
                EC 2.1.1.71                      phosphatidyl-N-methylethanolamine N-methyltransferase 
                EC 2.1.1.72                      site-specific DNA-methyltransferase (adenine-specific) 
                EC 2.1.1.73                       site-specific DNA-methyltransferase (cytosine-specific). Reaction is that of EC 2.1.1.37, DNA (cytosine-5-)-methyltransferase 
                EC 2.1.1.74                      methylenetetrahydrofolate—tRNA-(uracil54-C5)-methyltransferase (FADH2-oxidizing) 
                EC 2.1.1.75                      apigenin 4′-O-methyltransferase 
                EC 2.1.1.76                      quercetin 3-O-methyltransferase 
                EC 2.1.1.77                      protein-L-isoaspartate(D-aspartate) O-methyltransferase 
                EC 2.1.1.78                      isoorientin 3′-O-methyltransferase 
                EC 2.1.1.79                      cyclopropane-fatty-acyl-phospholipid synthase 
                EC 2.1.1.80                      protein-glutamate O-methyltransferase 
                EC 2.1.1.81                       nicotine N-methyltransferase. Now included with EC 2.1.1.49 amine N-methyltransferase 
                EC 2.1.1.82                      3-methylquercetin 7-O-methyltransferase 
                EC 2.1.1.83                      3,7-dimethylquercetin 4′-O-methyltransferase 
                EC 2.1.1.84                      methylquercetagetin 6-O-methyltransferase 
                EC 2.1.1.85                      protein-histidine N-methyltransferase 
                EC 2.1.1.86                      tetrahydromethanopterin S-methyltransferase 
                EC 2.1.1.87                      pyridine N-methyltransferase 
                EC 2.1.1.88                      8-hydroxyquercetin 8-O-methyltransferase 
                EC 2.1.1.89                      tetrahydrocolumbamine 2-O-methyltransferase 
                EC 2.1.1.90                      methanol—corrinoid protein Co-methyltransferase 
                EC 2.1.1.91                      isobutyraldoxime O-methyltransferase 
                EC 2.1.1.92                      bergaptol O-methyltransferase. Now included with EC 2.1.1.69, 5-hydroxyfuranocoumarin 5-O-methyltransferase. The reaction with bergaptol is a specific example of the general reaction associated with EC 2.1.1.69 
                EC 2.1.1.93                      xanthotoxol O-methyltransferase. Enzyme is identical to EC 2.1.1.70, 8-hydroxyfuranocoumarin 8-O-methyltransferase 
                EC 2.1.1.94                      tabersonine 16-O-methyltransferase 
                EC 2.1.1.95                      tocopherol O-methyltransferase 
                EC 2.1.1.96                      thioether S-methyltransferase 
                EC 2.1.1.97                      3-hydroxyanthranilate 4-C-methyltransferase 
                EC 2.1.1.98                      diphthine synthase 
                EC 2.1.1.99                      3-hydroxy-16-methoxy-2,3-dihydrotabersonine N-methyltransferase 
                EC 2.1.1.100                      protein-S-isoprenylcysteine O-methyltransferase 
                EC 2.1.1.101                      macrocin O-methyltransferase 
                EC 2.1.1.102                      demethylmacrocin O-methyltransferase 
                EC 2.1.1.103                      phosphoethanolamine N-methyltransferase 
                EC 2.1.1.104                      caffeoyl-CoA O-methyltransferase 
                EC 2.1.1.105                      N-benzoyl-4-hydroxyanthranilate 4-O-methyltransferase 
                EC 2.1.1.106                      tryptophan 2-C-methyltransferase 
                EC 2.1.1.107                      uroporphyrinogen-III C-methyltransferase 
                EC 2.1.1.108                      6-hydroxymellein O-methyltransferase 
                EC 2.1.1.109                      demethylsterigmatocystin 6-O-methyltransferase 
                EC 2.1.1.110                      sterigmatocystin 8-O-methyltransferase 
                EC 2.1.1.111                      anthranilate N-methyltransferase 
                EC 2.1.1.112                      glucuronoxylan 4-O-methyltransferase 
                EC 2.1.1.113                      site-specific DNA-methyltransferase (cytosine-N4-specific) 
                EC 2.1.1.114                      polyprenyldihydroxybenzoate methyltransferase 
                EC 2.1.1.115                      (RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline N-methyltransferase 
                EC 2.1.1.116                      3′-hydroxy-N-methyl-(S)-coclaurine 4′-O-methyltransferase 
                EC 2.1.1.117                      (S)-scoulerine 9-O-methyltransferase 
                EC 2.1.1.118                      columbamine O-methyltransferase 
                EC 2.1.1.119                      10-hydroxydihydrosanguinarine 10-O-methyltransferase 
                EC 2.1.1.120                      12-hydroxydihydrochelirubine 12-O-methyltransferase 
                EC 2.1.1.121                      6-O-methylnorlaudanosoline 5′-O-methyltransferase 
                EC 2.1.1.122                      (S)-tetrahydroprotoberberine N-methyltransferase 
                EC 2.1.1.123                      [cytochrome-c]-methionine S-methyltransferase 
                EC 2.1.1.124                      [cytochrome c]-arginine N-methyltransferase. Now covered by EC 2.1.1.319, type I protein arginine methyltransferase, EC 2.1.1.320, type II protein arginine methyltransferase, EC 2.1.1.321, type III protein arginine methyltransferase and EC 2.1.1.322, type IV protein arginine methyltransferase 
                EC 2.1.1.125                      histone-arginine N-methyltransferase. Now covered by EC 2.1.1.319, type I protein arginine methyltransferase, EC 2.1.1.320, type II protein arginine methyltransferase, EC 2.1.1.321, type III protein arginine methyltransferase and EC 2.1.1.322, type IV protein arginine methyltransferase 
                EC 2.1.1.126                      [myelin basic protein]-arginine N-methyltransferase. Now covered by EC 2.1.1.319, type I protein arginine methyltransferase, EC 2.1.1.320, type II protein arginine methyltransferase, EC 2.1.1.321, type III protein arginine methyltransferase and EC 2.1.1.322, type IV protein arginine methyltransferase 
                EC 2.1.1.127                      [ribulose-bisphosphate carboxylase]-lysine N-methyltransferase 
                EC 2.1.1.128                      (RS)-norcoclaurine 6-O-methyltransferase 
                EC 2.1.1.129                      inositol 4-methyltransferase 
                EC 2.1.1.130                      precorrin-2 C20-methyltransferase 
                EC 2.1.1.131                      precorrin-3B C17-methyltransferase 
                EC 2.1.1.132                      precorrin-6B C5,15-methyltransferase (decarboxylating) 
                EC 2.1.1.133                      precorrin-4 C11-methyltransferase 
                EC 2.1.1.134                       myo-inositol 6-O-methyltransferase. Now included with EC 2.1.1.129, inositol 4-methyltransferase 
                EC 2.1.1.135                      [methionine synthase]-cobalamin methyltransferase (cob(II)alamin reducing). Now EC 1.16.1.8, [methionine synthase] reductase 
                EC 2.1.1.136                      chlorophenol O-methyltransferase 
                EC 2.1.1.137                      arsenite methyltransferase 
                EC 2.1.1.138                       methylarsonite methyltransferase. Reaction due to EC 2.1.1.137, arsonite methyltransferase 
                EC 2.1.1.139                      3′-demethylstaurosporine O-methyltransferase 
                EC 2.1.1.140                      (S)-coclaurine-N-methyltransferase 
                EC 2.1.1.141                      jasmonate O-methyltransferase 
                EC 2.1.1.142                      cycloartenol 24-C-methyltransferase 
                EC 2.1.1.143                      24-methylenesterol C-methyltransferase 
                EC 2.1.1.144                      trans-aconitate 2-methyltransferase 
                EC 2.1.1.145                      trans-aconitate 3-methyltransferase 
                EC 2.1.1.146                      (iso)eugenol O-methyltransferase 
                EC 2.1.1.147                      corydaline synthase 
                EC 2.1.1.148                      thymidylate synthase (FAD) 
                EC 2.1.1.149                      myricetin O-methyltransferase. Now covered by EC 2.1.1.267, flavonoid 3′,5′-methyltransferase. 
                EC 2.1.1.150                      isoflavone 7-O-methyltransferase 
                EC 2.1.1.151                      cobalt-factor II C20-methyltransferase 
                EC 2.1.1.152                      precorrin-6A synthase (deacetylating) 
                EC 2.1.1.153                      vitexin 2′′-O-rhamnoside 7-O-methyltransferase 
                EC 2.1.1.154                      isoliquiritigenin 2′-O-methyltransferase 
                EC 2.1.1.155                      kaempferol 4′-O-methyltransferase 
                EC 2.1.1.156                      glycine/sarcosine N-methyltransferase 
                EC 2.1.1.157                      sarcosine/dimethylglycine N-methyltransferase 
                EC 2.1.1.158                      7-methylxanthosine synthase 
                EC 2.1.1.159                      theobromine synthase 
                EC 2.1.1.160                      caffeine synthase 
                EC 2.1.1.161                      dimethylglycine N-methyltransferase 
                EC 2.1.1.162                      glycine/sarcosine/dimethylglycine N-methyltransferase 
                EC 2.1.1.163                      demethylmenaquinone methyltransferase 
                EC 2.1.1.164                      demethylrebeccamycin-D-glucose O-methyltransferase 
                EC 2.1.1.165                      methyl halide transferase 
                EC 2.1.1.166                      23S rRNA (uridine2552-2′-O)-methyltransferase 
                EC 2.1.1.167                      27S pre-rRNA (guanosine2922-2′-O)-methyltransferase 
                EC 2.1.1.168                      21S rRNA (uridine2791-2′-O)-methyltransferase 
                EC 2.1.1.169                      tricetin 3′,4′,5′-O-trimethyltransferase 
                EC 2.1.1.170                      16S rRNA (guanine527-N7)-methyltransferase 
                EC 2.1.1.171                      16S rRNA (guanine966-N2)-methyltransferase 
                EC 2.1.1.172                      16S rRNA (guanine1207-N2)-methyltransferase 
                EC 2.1.1.173                      23S rRNA (guanine2445-N2)-methyltransferase 
                EC 2.1.1.174                      23S rRNA (guanine1835-N2)-methyltransferase 
                EC 2.1.1.175                      tricin synthase 
                EC 2.1.1.176                      16S rRNA (cytosine967-C5)-methyltransferase 
                EC 2.1.1.177                      23S rRNA (pseudouridine1915-N3)-methyltransferase 
                EC 2.1.1.178                      16S rRNA (cytosine1407-C5)-methyltransferase 
                EC 2.1.1.179                      16S rRNA (guanine1405-N7)-methyltransferase 
                EC 2.1.1.180                      16S rRNA (adenine1408-N1)-methyltransferase 
                EC 2.1.1.181                      23S rRNA (adenine1618-N6)-methyltransferase 
                EC 2.1.1.182                      16S rRNA (adenine1518-N6/adenine1519-N6)-dimethyltransferase 
                EC 2.1.1.183                      18S rRNA (adenine1779-N6/adenine1780-N6)-dimethyltransferase 
                EC 2.1.1.184                      23S rRNA (adenine2085-N6)-dimethyltransferase 
                EC 2.1.1.185                      23S rRNA (guanosine2251-2′-O)-methyltransferase 
                EC 2.1.1.186                      23S rRNA (cytidine2498-2′-O)-methyltransferase 
                EC 2.1.1.187                      23S rRNA (guanine745-N1)-methyltransferase 
                EC 2.1.1.188                      23S rRNA (guanine748-N1)-methyltransferase 
                EC 2.1.1.189                      23S rRNA (uracil747-C5)-methyltransferase 
                EC 2.1.1.190                      23S rRNA (uracil1939-C5)-methyltransferase 
                EC 2.1.1.191                      23S rRNA (cytosine1962-C5)-methyltransferase 
                EC 2.1.1.192                      23S rRNA (adenine2503-C2)-methyltransferase 
                EC 2.1.1.193                      16S rRNA (uracil1498-N3)-methyltransferase 
                EC 2.1.1.194                      23S rRNA (adenine2503-C2,C8)-dimethyltransferase. A mixture of EC 2.1.1.192 (23S rRNA (adenine2503-C2)-methyltransferase) and EC 2.1.1.224 (23S rRNA (adenine2503-C8)-methyltransferase) 
                EC 2.1.1.195                      cobalt-precorrin-5B (C1)-methyltransferase 
                EC 2.1.1.196                      cobalt-precorrin-6B (C15)-methyltransferase [decarboxylating] 
                EC 2.1.1.197                      malonyl-[acyl-carrier protein] O-methyltransferase 
                EC 2.1.1.198                      16S rRNA (cytidine1402-2′-O)-methyltransferase 
                EC 2.1.1.199                      16S rRNA (cytosine1402-N4)-methyltransferase 
                EC 2.1.1.200                      tRNA (cytidine32/uridine32-2′-O)-methyltransferase 
                EC 2.1.1.201                      2-methoxy-6-polyprenyl-1,4-benzoquinol methylase 
                EC 2.1.1.202                      multisite-specific tRNA:(cytosine-C5)-methyltransferase 
                EC 2.1.1.203                      tRNA (cytosine34-C5)-methyltransferase 
                EC 2.1.1.204                      tRNA (cytosine38-C5)-methyltransferase 
                EC 2.1.1.205                      tRNA (cytidine32/guanosine34-2′-O)-methyltransferase 
                EC 2.1.1.206                      tRNA (cytidine56-2′-O)-methyltransferase 
                EC 2.1.1.207                      tRNA (cytidine34-2′-O)-methyltransferase 
                EC 2.1.1.208                      23S rRNA (uridine2479-2′-O)-methyltransferase 
                EC 2.1.1.209                      23S rRNA (guanine2535-N1)-methyltransferase 
                EC 2.1.1.210                      demethylspheroidene O-methyltransferase 
                EC 2.1.1.211                      tRNASer (uridine44-2′-O)-methyltransferase 
                EC 2.1.1.212                      2,7,4′-trihydroxyisoflavanone 4′-O-methyltransferase 
                EC 2.1.1.213                      tRNA (guanine10-N2)-dimethyltransferase 
                EC 2.1.1.214                      tRNA (guanine10-N2)-methyltransferase 
                EC 2.1.1.215                      tRNA (guanine26-N2/guanine27-N2)-dimethyltransferase 
                EC 2.1.1.216                      tRNA (guanine26-N2)-dimethyltransferase 
                EC 2.1.1.217                      tRNA (adenine22-N1)-methyltransferase 
                EC 2.1.1.218                      tRNA (adenine9-N1)-methyltransferase 
                EC 2.1.1.219                      tRNA (adenine57-N1/adenine58-N1)-methyltransferase 
                EC 2.1.1.220                      tRNA (adenine58-N1)-methyltransferase 
                EC 2.1.1.221                      tRNA (guanine9-N1)-methyltransferase 
                EC 2.1.1.222                      2-polyprenyl-6-hydroxyphenol methylase 
                EC 2.1.1.223                      tRNA1Val (adenine37-N6)-methyltransferase 
                EC 2.1.1.224                      23S rRNA (adenine2503-C8)-methyltransferase 
                EC 2.1.1.225                      tRNA:m4X modification enzyme 
                EC 2.1.1.226                      23S rRNA (cytidine1920-2′-O)-methyltransferase 
                EC 2.1.1.227                      16S rRNA (cytidine1409-2′-O)-methyltransferase 
                EC 2.1.1.228                      tRNA (guanine37-N1)-methyltransferase 
                EC 2.1.1.229                      tRNA (carboxymethyluridine34-5-O)-methyltransferase 
                EC 2.1.1.230                      23S rRNA (adenosine1067-2′-O)-methyltransferase 
                EC 2.1.1.231                      flavonoid 4′-O-methyltransferase 
                EC 2.1.1.232                      naringenin 7-O-methyltransferase 
                EC 2.1.1.233                      [phosphatase 2A protein]-leucine-carboxy methyltransferase 
                EC 2.1.1.234                      dTDP-3-amino-3,4,6-trideoxy-α-D-glucopyranose N,N-dimethyltransferase 
                EC 2.1.1.235                      dTDP-3-amino-3,6-dideoxy-α-D-glucopyranose N,N-dimethyltransferase 
                EC 2.1.1.236                      dTDP-3-amino-3,6-dideoxy-α-D-galactopyranose N,N-dimethyltransferase 
                EC 2.1.1.237                      mycinamicin III 3′′-O-methyltransferase 
                EC 2.1.1.238                      mycinamicin VI 2′′-O-methyltransferase 
                EC 2.1.1.239                      L-olivosyl-oleandolide 3-O-methyltransferase 
                EC 2.1.1.240                      trans-resveratrol di-O-methyltransferase 
                EC 2.1.1.241                      2,4,7-trihydroxy-1,4-benzoxazin-3-one-glucoside 7-O-methyltransferase 
                EC 2.1.1.242                      16S rRNA (guanine1516-N2)-methyltransferase 
                EC 2.1.1.243                      2-ketoarginine methyltransferase 
                EC 2.1.1.244                      protein N-terminal methyltransferase 
                EC 2.1.1.245                      5-methyltetrahydrosarcinapterin:corrinoid/iron-sulfur protein Co-methyltransferase 
                EC 2.1.1.246                      [methyl-Co(III) methanol-specific corrinoid protein]:coenzyme M methyltransferase 
                EC 2.1.1.247                      [methyl-Co(III) methylamine-specific corrinoid protein]:coenzyme M methyltransferase 
                EC 2.1.1.248                      methylamine—corrinoid protein Co-methyltransferase 
                EC 2.1.1.249                      dimethylamine—corrinoid protein Co-methyltransferase 
                EC 2.1.1.250                      trimethylamine—corrinoid protein Co-methyltransferase 
                EC 2.1.1.251                      methylated-thiol—coenzyme M methyltransferase 
                EC 2.1.1.252                      tetramethylammonium—corrinoid protein Co-methyltransferase 
                EC 2.1.1.253                      [methyl-Co(III) tetramethylammonium-specific corrinoid protein]:coenzyme M methyltransferase 
                EC 2.1.1.254                      erythromycin 3′′-O-methyltransferase 
                EC 2.1.1.255                      geranyl diphosphate 2-C-methyltransferase 
                EC 2.1.1.256                      tRNA (guanine6-N2)-methyltransferase 
                EC 2.1.1.257                      tRNA (pseudouridine54-N1)-methyltransferase 
                EC 2.1.1.258                      5-methyltetrahydrofolate:corrinoid/iron-sulfur protein Co-methyltransferase 
                EC 2.1.1.259                      [fructose-bisphosphate aldolase]-lysine N-methyltransferase 
                EC 2.1.1.260                      rRNA small subunit pseudouridine methyltransferase Nep1 
                EC 2.1.1.261                      4-dimethylallyltryptophan N-methyltransferase 
                EC 2.1.1.262                      squalene methyltransferase 
                EC 2.1.1.263                      botryococcene C-methyltransferase 
                EC 2.1.1.264                      23S rRNA (guanine2069-N7)-methyltransferase 
                EC 2.1.1.265                      tellurite methyltransferase 
                EC 2.1.1.266                      23S rRNA (adenine2030-N6)-methyltransferase 
                EC 2.1.1.267                      flavonoid 3′,5′-methyltransferase 
                EC 2.1.1.268                      tRNAThr (cytosine32-N3)-methyltransferase  
                EC 2.1.1.269                      dimethylsulfoniopropionate demethylase 
                EC 2.1.1.270                      (+)-6a-hydroxymaackiain 3-O-methyltransferase 
                EC 2.1.1.271                      cobalt-precorrin-4 methyltransferase 
                EC 2.1.1.272                      cobalt-factor III methyltransferase 
                EC 2.1.1.273                      benzoate O-methyltransferase 
                EC 2.1.1.274                      salicylate 1-O-methyltransferase 
                EC 2.1.1.275                      gibberellin A9 O-methyltransferase 
                EC 2.1.1.276                      gibberellin A4 carboxyl methyltransferase 
                EC 2.1.1.277                      anthranilate O-methyltransferase 
                EC 2.1.1.278                      indole-3-acetate O-methyltransferase 
                EC 2.1.1.279                      trans-anol O-methyltransferase 
                EC 2.1.1.280                      selenocysteine Se-methyltransferase 
                EC 2.1.1.281                      phenylpyruvate C3-methyltransferase 
                EC 2.1.1.282                      tRNAPhe 7-[(3-amino-3-carboxypropyl)-4-demethylwyosine37-N4]-methyltransferase 
                EC 2.1.1.283                      emodin O-methyltransferase 
                EC 2.1.1.284                      8-demethylnovobiocic acid C8-methyltransferase 
                EC 2.1.1.285                      demethyldecarbamoylnovobiocin O-methyltransferase 
                EC 2.1.1.286                      25S rRNA (adenine2142-N1)-methyltransferase 
                EC 2.1.1.287                      25S rRNA (adenine645-N1)-methyltransferase 
                EC 2.1.1.288                      aklanonic acid methyltransferase 
                EC 2.1.1.289                      cobalt-precorrin-7 (C5)-methyltransferase 
                EC 2.1.1.290                      tRNAPhe [7-(3-amino-3-carboxypropyl)wyosine37-O]-methyltransferase 
                EC 2.1.1.291                      (R,S)-reticuline 7-O-methyltransferase 
                EC 2.1.1.292                      carminomycin 4-O-methyltransferase 
                EC 2.1.1.293                      6-hydroxytryprostatin B O-methyltransferase 
                EC 2.1.1.294                      3-O-phospho-polymannosyl GlcNAc-diphospho-ditrans,octacis-undecaprenol 3-phospho-methyltransferase 
                EC 2.1.1.295                      2-methyl-6-phytyl-1,4-hydroquinone methyltransferase 
                EC 2.1.1.296                      methyltransferase cap2 
                EC 2.1.1.297                      peptide chain release factor N5-glutamine methyltransferase 
                EC 2.1.1.298                      ribosomal protein L3 N5-glutamine methyltransferase 
                EC 2.1.1.299                      protein N-terminal monomethyltransferase 
                EC 2.1.1.300                      pavine N-methyltransferase 
                EC 2.1.1.301                      cypemycin N-terminal methyltransferase  
                EC 2.1.1.302                      3-hydroxy-5-methyl-1-naphthoate 3-O-methyltransferase 
                EC 2.1.1.303                      2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase 
                EC 2.1.1.304                      L-tyrosine C3-methyltransferase 
                EC 2.1.1.305                      8-demethyl-8-α-L-rhamnosyltetracenomycin-C 2′-O-methyltransferase 
                EC 2.1.1.306                      8-demethyl-8-(2-methoxy-α-L-rhamnosyl)tetracenomycin-C 3′-O-methyltransferase 
                EC 2.1.1.307                      8-demethyl-8-(2,3-dimethoxy-α-L-rhamnosyl)tetracenomycin-C 4′-O-methyltransferase 
                EC 2.1.1.308                      2-hydroxyethylphosphonate methyltransferase 
                EC 2.1.1.309                      18S rRNA (guanine1575-N7)-methyltransferase 
                EC 2.1.1.310                      25S rRNA (cytosine2870-C5)-methyltransferase 
                EC 2.1.1.311                      25S rRNA (cytosine2278-C5)-methyltransferase 
                EC 2.1.1.312                      25S rRNA (uracil2843-N3)-methyltransferase 
                EC 2.1.1.313                      25S rRNA (uracil2634-N3)-methyltransferase 
                EC 2.1.1.314                      diphthine methyl ester synthase 
                EC 2.1.1.315                      27-O-demethylrifamycin SV methyltransferase 
                EC 2.1.1.316                      mitomycin 6-O-methyltransferase 
                EC 2.1.1.317                      sphingolipid C9-methyltransferase 
                EC 2.1.1.318                      [trehalose-6-phosphate synthase]-L-cysteine S-methyltransferase 
                EC 2.1.1.319                      type I protein arginine methyltransferase 
                EC 2.1.1.320                      type II protein arginine methyltransferase 
                EC 2.1.1.321                      type III protein arginine methyltransferase 
                EC 2.1.1.322                      type IV protein arginine methyltransferase 
                EC 2.1.1.323                      (–)-pluviatolide 4-O-methyltransferase 
                EC 2.1.1.324                      dTDP-4-amino-2,3,4,6-tetradeoxy-D-glucose N,N-dimethyltransferase 
                EC 2.1.1.325                      juvenile hormone-III synthase 
                EC 2.1.1.326                      N-acetyldemethylphosphinothricin P-methyltransferase 
                EC 2.1.1.327                      phenazine-1-carboxylate N-methyltransferase 
                EC 2.1.1.328                      N-demethylindolmycin N-methyltransferase 
                EC 2.1.1.329                      demethylphylloquinol methyltransferase 
                EC 2.1.1.330                      5′-demethylyatein 5′-O-methyltransferase 
                EC 2.1.1.331                      bacteriochlorophyllide d C-121-methyltransferase 
                EC 2.1.1.332                      bacteriochlorophyllide d C-82-methyltransferase 
                EC 2.1.1.333                      bacteriochlorophyllide d C-20 methyltransferase 
                EC 2.1.1.334                      methanethiol S-methyltransferase 
                EC 2.1.1.335                      4-amino-anhydrotetracycline N4-methyltransferase 
                EC 2.1.1.336                      norbelladine O-methyltransferase 
                EC 2.1.1.337                      reticuline N-methyltransferase 
                EC 2.1.1.338                      desmethylxanthohumol 6′-O-methyltransferase 
                EC 2.1.1.339                      xanthohumol 4′-O-methyltransferase 
        EC 2.1.2       []    Hydroxymethyl-, formyl- and related transferases 
                EC 2.1.2.1                      glycine hydroxymethyltransferase 
                EC 2.1.2.2                      phosphoribosylglycinamide formyltransferase 
                EC 2.1.2.3                      phosphoribosylaminoimidazolecarboxamide formyltransferase 
                EC 2.1.2.4                      glycine formimidoyltransferase 
                EC 2.1.2.5                      glutamate formimidoyltransferase 
                EC 2.1.2.6                       glutamate formyltransferase. Now included with EC 2.1.2.5, glutamate formimidoyltransferase 
                EC 2.1.2.7                      D-alanine 2-hydroxymethyltransferase 
                EC 2.1.2.8                      deoxycytidylate 5-hydroxymethyltransferase 
                EC 2.1.2.9                      methionyl-tRNA formyltransferase 
                EC 2.1.2.10                      aminomethyltransferase 
                EC 2.1.2.11                      3-methyl-2-oxobutanoate hydroxymethyltransferase 
                EC 2.1.2.12                       now EC 2.1.1.74 methylenetetrahydrofolate-tRNA-(uracil-5-)-methyltransferase (FADH2-oxidizing) 
                EC 2.1.2.13                      UDP-4-amino-4-deoxy-L-arabinose formyltransferase 
        EC 2.1.3       []    Car